The physiological basis of uterine contractility: a short review.

Abstract:

:In this review we discuss our current understanding of the cellular basis of uterine contractility, highlighting those areas requiring further study. It is clear that the basic processes of excitation-contraction coupling lie within the myometrial cell, and that these may be modified by agonists. Pacemaker activity, however, remains a mystery. The contribution of extracellular calcium entry to contraction is shown to be vital, whilst the role of the sarcoplasmic reticulum remains controversial. Much current experimental focus is on pathways controlling and regulating contraction, and we discuss sensitisation mechanisms and question their role in intact uterine preparations. Experimental Physiology (2001) 86.2, 239-246.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Wray S,Kupittayanant S,Shmygol A,Smith RD,Burdyga T

doi

10.1113/eph8602114

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

239-46

issue

2

eissn

0958-0670

issn

1469-445X

pii

EPH_2114

journal_volume

86

pub_type

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