The effect of surgical anaesthesia on antral motility in the ferret.

abstract：:Changes in tension of slow motor units in the medial gastrocnemius muscle of the rat were measured and compared in three fatigue tests, each of 4 min duration. In one of these tests motor unit tetani were evoked by repeated trains of stimuli of the standard frequency, 40 Hz, while in other tests frequencies of 20 and ...

journal_title：Experimental physiology

authors： Celichowski J,Grottel K

更新日期：1995-11-01 00:00:00

abstract：:We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

journal_title：Experimental physiology

authors： Cairns SP,Robinson DM,Loiselle DS

更新日期：2008-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...

journal_title：Experimental physiology

authors： Zhang W,Yu T,Cui X,Yu H,Li X

更新日期：2020-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is mesenchymal stem cell-conditioned medium capable of improving the pathological alterations of ovalbumin-induced asthma in mice? What is the main finding and its importance? Our study indicated that human amniotic membrane mesenchymal stem cell-conditioned medi...

journal_title：Experimental physiology

authors： Dalouchi F,Falak R,Bakhshesh M,Sharifiaghdam Z,Azizi Y,Aboutaleb N

更新日期：2020-12-01 00:00:00

abstract：:Tumour cell survival is intimately related to blood vessel function and so the tumour vasculature represents a novel target for cancer therapy. We have investigated a murine tumour model in which a metal clamp was used to occlude the vascular supply temporarily and then removed to allow reperfusion. This allows the st...

journal_title：Experimental physiology

authors： Parkins CS,Hill SA,Stratford MR,Dennis MF,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：:Ionic mechanisms and signal transduction underlying noradrenaline (NA)-induced depolarization in single smooth muscle cells of guinea-pig vas deferens were studied. NA caused depolarization followed by action potentials through activation of 1-adrenoceptors. In the presence of nifedipine, no action potential was gener...

journal_title：Experimental physiology

authors： Kamimura N,Suga S,Nakano K,Kanno T,Takeo T,Wakui M

更新日期：2000-01-01 00:00:00

abstract：:Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...

journal_title：Experimental physiology

authors： Osborn JW,Averina VA,Fink GD

更新日期：2009-04-01 00:00:00

abstract：:An energy-rich diet leads to enhanced ruminal Na(+) absorption, which is associated with elevated plasma insulin-like growth factor 1 (IGF-1) levels and an increased number of IGF-1 receptors in rumen papillae. This study examined the in vitro effect of IGF-1 on Na(+) transport across the rumen epithelium of hay-fed s...

journal_title：Experimental physiology

authors： Shen Z,Martens H,Schweigel-Röntgen M

更新日期：2012-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and...

journal_title：Experimental physiology

authors： Oliveira LM,Oliveira MA,Moriya HT,Moreira TS,Takakura AC

更新日期：2019-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We examined whether the macrophage-synthesized antioxidant 7,8-dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8-dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction-ind...

journal_title：Experimental physiology

authors： Lindsay A,Schmiechen A,Chamberlain CM,Ervasti JM,Lowe DA

更新日期：2018-07-01 00:00:00

abstract：:The endothelial glycocalyx layer of capillaries was stained with Ruthenium Red and examined by transmission electron microscopy in rat extensor hallucis proprius muscles after 2 or 4 days of indirect electrical stimulation via implanted electrodes. The layer appeared continuous on the luminal surface of 63% capillarie...

journal_title：Experimental physiology

authors： Brown MD,Egginton S,Hudlicka O,Zhou AL

更新日期：1996-11-01 00:00:00

abstract：:Altering [K+]o might have different effects on action potential duration (APD) in myocytes from different regions. Therefore, the effects of [K+]o on regional differences in action potential characteristics were investigated in sub-endocardial, mid-myocardial and sub-epicardial myocytes isolated from the base of guine...

journal_title：Experimental physiology

authors： Wan X,Bryant SM,Hart G

更新日期：2000-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...

journal_title：Experimental physiology

authors： Mosca EV,Rousseau JP,Gulemetova R,Kinkead R,Wilson RJ

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Exercise can stimulate brown adipose tissue (BAT) with subsequent increase in uncoupling protein 1 expression and mitochondrial biogenesis. In that case, do BAT-specific Hox genes modify BAT functioning and cause uncoupling protein expression changes due to exerc...

journal_title：Experimental physiology

authors： Kato H,Ario T,Kishida T,Tadano M,Osawa S,Maeda Y,Takakura H,Izawa T

更新日期：2020-12-28 00:00:00

abstract：:We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...

journal_title：Experimental physiology

authors： Best SA,Okada Y,Galbreath MM,Jarvis SS,Bivens TB,Adams-Huet B,Fu Q

更新日期：2014-06-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review concerns the negative impact of pulmonary hypertension (PH) on the pulmonary haemodynamic and gas exchange responses to exercise, considering the mechanisms by which PH plays a role in exercise intolerance in heart failure (HF) patients. What advances does it h...

journal_title：Experimental physiology

authors： Taylor BJ,Shapiro BP,Johnson BD

更新日期：2020-02-24 00:00:00

abstract：:An imaging technique (laser Doppler perfusion imaging, LDI), based on measurement of backscattered Doppler-broadened laser radiation, was used to provide two-dimensional images of perfusion in the exposed rat knee joint capsule. In control animals, frequency-dependent constriction of knee joint blood vessels occurred ...

journal_title：Experimental physiology

authors： Karimian SM,McDougall JJ,Ferrell WR

更新日期：1995-05-01 00:00:00

abstract：:This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...

journal_title：Experimental physiology

authors： Iannitti T,Graham A,Dolan S

更新日期：2012-11-01 00:00:00

abstract：:Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...

journal_title：Experimental physiology

authors： Bee D,Emery CJ,Howard P

更新日期：1992-11-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? The sympathetic control of renal sodium tubular reabsorption is dependent on activation of the intrarenal renin-angiotensin system and activation of the angiotensin II type 1 (AT1 ) receptor by angiotensin II. What advances does it highlight? Despite the fact that the inte...

journal_title：Experimental physiology

authors： Pontes RB,Girardi AC,Nishi EE,Campos RR,Bergamaschi CT

更新日期：2015-04-20 00:00:00

abstract：:Hypoxia has been reported to increase arterial potassium concentration ([K+]a) in anaesthetized cats (Paterson, Estavillo & Nye, 1988). The purpose of this study was to determine whether this phenomenon occurs in humans. The effect of hypoxia on [K+]a was measured in ten male subjects, at rest and during light exercis...

journal_title：Experimental physiology

authors： Barlow CW,Qayyum MS,Davey PP,Paterson DJ,Robbins PA

更新日期：1994-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review provides a comprehensive overview of Nox5 from basic biology to human disease and highlights unique features of this Nox isoform What advances does it highlight? Major advances in Nox5 biology relate to crystallization of the molecule and new insights into the ...

journal_title：Experimental physiology

authors： Touyz RM,Anagnostopoulou A,Rios F,Montezano AC,Camargo LL

更新日期：2019-05-01 00:00:00

abstract：:The renal medulla contains more mRNA of the inducible isoform of nitric oxide synthase (iNOS) than the cortex, which may be important in preventing ischaemic injury, since blood flow and tissue oxygen tension are normally low in this region. We examined the effects of the bacterial endotoxin E. coli lipopolysaccharide...

journal_title：Experimental physiology

authors： Chou DE,Cai H,Jayadevappa D,Porush JG

更新日期：2002-03-01 00:00:00

abstract：:The effect of the neuronal 5-HT3 receptor antagonist MDL 72222 has been investigated on the reflex tachypnoeic response to pulmonary embolism in pentobarbitone-anaesthetized rabbits. Pre-treatment with MDL 72222 (640 micrograms kg-1, 5 min prior to embolization) significantly attenuated the reflex tachypnoeic response...

journal_title：Experimental physiology

authors： Armstrong DJ,Kay IS

更新日期：1990-07-01 00:00:00

abstract：:The effects of hypotonic solutions on intracellular Ca2+ were determined on primary cultures of human detrusor smooth muscle cells. In the presence of external Ca2+, changing from a solution containing 290 mosmol l-1 to one containing 240 mosmol l-1 (80% normal tonicity) activated a rise in intracellular Ca2+. If the ...

journal_title：Experimental physiology

authors： Chambers P,Neal DE,Gillespie JI

更新日期：1997-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inf...

journal_title：Experimental physiology

authors： Koyuncuoğlu T,Arabacı Tamer S,Erzik C,Karagöz A,Akakın D,Yüksel M,Yeğen BÇ

更新日期：2019-12-01 00:00:00

abstract：:After 2 months of streptozotocin-induced diabetes in rats, the membrane potential of the diaphragm muscle when measured in vitro at 30 degrees C was unchanged but the tetanic tension, the half-relaxation time of the isometric twitch and the fatigue resistance were each reduced. Treatment of the diabetic rats with the ...

journal_title：Experimental physiology

authors： McGuire M,MacDermott M

更新日期：1998-07-01 00:00:00

abstract：:Animal studies show that arginine vasopressin facilitates aggression, while serotonin (5-HT) inhibits aggression by blocking the activity of the vasopressin system. Clinical studies report that subjects with a history of 'fighting and assault' show a significant positive correlation between cerebrospinal fluid concent...

journal_title：Experimental physiology

authors： Ferris CF

更新日期：2000-03-01 00:00:00

abstract：:The contribution of almitrine bismesylate to the occurrence and pattern of augmented breaths was studied in fifteen spontaneously breathing, anaesthetized cats. Breathing was via a tracheostomy, while the laryngeal resistance to airflow was measured with the larynx isolated in situ. Almitrine bismesylate at a dose of ...

journal_title：Experimental physiology

authors： Szereda-Przestaszewska M,Jakus J,Stránsky A,Baráni H

更新日期：1992-01-01 00:00:00