Abstract:
NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary adenylate cyclase-activating peptide or its receptors, but sex differences exist in these genes between males and females at baseline. Sex differences in classic stress hormones have been studied in depth, but pituitary adenylate cyclase-activating peptide (PACAP), recently identified as playing a critical role in the stress axes, has not. Here we studied whether baseline levels of PACAP differ between sexes in various stress-related tissues and whether neonatal-maternal separation stress has a sex-dependent effect on PACAP gene expression in stress pathways. Using quantitative RT-PCR, we found sex differences in PACAP and PACAP receptor gene expression in several respiratory and/or stress-related tissues, while neonatal-maternal separation stress did little to affect PACAP signalling in adult animals. We propose that sex differences in PACAP expression are likely to contribute to differences between males and females in responses to stress.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Mosca EV,Rousseau JP,Gulemetova R,Kinkead R,Wilson RJdoi
10.1113/expphysiol.2014.082180subject
Has Abstractpub_date
2015-02-01 00:00:00pages
203-15issue
2eissn
0958-0670issn
1469-445Xpii
expphysiol.2014.082180journal_volume
100pub_type
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