Abstract:
NEW FINDINGS:What is the central question of this study? Does blockade of the IL-6 receptor by tocilizumab inhibit immune cell mobilization to the blood stream in humans during an acute bout of exercise? What is the main finding and its importance? Blockade of IL-6 receptor signalling by tocilizumab attenuates mobilization of NK cells and dendritic cells to the blood stream during exercise. This implies an inhibitory effect of tocilizumab on the innate immune response to physical stress, which could be considered in clinical settings. ABSTRACT:Immune cells are recruited from their storage organs and the endothelial walls to the blood stream in response to physiological stress. This is essential for the recognition and clearing of infected, transformed or damaged cells. One of the most potent stimuli to recruit immune cells to the circulation is exercise. Accordingly, exercise has proven beneficial in disease settings, such as cancer and diabetes. Interleukin-6 (IL-6) is released from contracting skeletal muscle in response to exercise, and rodent studies have established a link between exercise-induced IL-6 and recruitment of natural killer (NK) cells. Whether exercise-induced IL-6 is involved in regulating NK cell mobilization in humans is unclear. This study explored the effect of IL-6 receptor blockade on immune cell mobilization during an acute bout of exercise in humans. In a randomized, placebo-controlled clinical study, abdominally obese humans receiving placebo infusions or tocilizumab infusions performed an acute bout of exercise before and after the intervention. Immune cell recruitment was measured by flow cytometry. IL-6 receptor blockade attenuated the increase of NK cells by 53% (mean difference -0.49 (95% CI: -0.89 to -0.08) × 109 cells L-1 , P < 0.001) and dendritic cells by 66% (mean difference -0.14 (95% CI: -0.28 to 0.010) × 109 cells L-1 , P < 0.001) induced by an acute bout of exercises. No changes were observed for T cells, monocytes and neutrophils. Treatments which interact with the exercise-mediated immune surveillance provide relevant clinical information in pursuing the 'exercise as medicine' concept.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Bay ML,Heywood S,Wedell-Neergaard AS,Schauer T,Lehrskov LL,Christensen RH,Legård GE,Jensen PØ,Krogh-Madsen R,Ellingsgaard Hdoi
10.1113/EP088864subject
Has Abstractpub_date
2020-10-02 00:00:00eissn
0958-0670issn
1469-445Xpub_type
杂志文章abstract::The effects of modification of the levels of endogenous plasma insulin on intestinal epithelial cell proliferation were investigated in rats maintained by total parenteral nutrition (TPN) using either a TPN diet that was high in glucose, or a low glucose (hypocaloric) TPN diet and in orally fed rats (normal and sham o...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003717
更新日期:1993-09-01 00:00:00
abstract::Aldosterone influences the kidney's regulation of blood pressure (BP), but aldosterone can contribute to the pathogenesis of hypertension. Blood pressure is reduced with aerobic exercise training (AEX), but the extent to which plasma aldosterone (PA) levels change is unclear. The purpose of this study was to determine...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.037408
更新日期:2007-09-01 00:00:00
abstract::We have considered the manner in which data obtained with ion-selective electrodes should be evaluated. The potential difference recorded by such electrodes, with respect to a stable reference, is converted to a concentration by a non-linear transformation--the Nernst or Nikolsky equation. The mean and standard deviat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003393
更新日期:1990-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What factors influence the onset and magnitude of activation of the neck inspiratory muscles during inspiration? What is the main finding and its importance? Recruitment of the sternocleidomastoid and scalene muscles during inspiration, measured by means of surfa...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087247
更新日期:2019-04-01 00:00:00
abstract::We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.077248
更新日期:2014-06-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do individuals with a patent foramen ovale (PFO+ ) have a larger alveolar-to-arterial difference in P O 2 ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088750
更新日期:2020-09-01 00:00:00
abstract::Intestinal secretion is enhanced by starvation in rats. The rectum from fed and 3-day-starved rats generates a basal electrogenic ion transfer (short-circuit current) in vitro which is mainly electrogenic Na+ absorption (amiloride-sensitive, 66-71%) with a small component of electrogenic chloride secretion (furosemide...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003438
更新日期:1990-07-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review describes the role of renal nerves as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body. What advances does it highlight? Whether renal or autonomic ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2014.079889
更新日期:2015-04-20 00:00:00
abstract::We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen uptake (O2) were associated with a greater initial rise in O2 (O2 /W, where W is work rate) following the onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2005.031708
更新日期:2006-01-01 00:00:00
abstract::Exposure to whole-body vibration is implicated as one of the occupational risk factors for lower back disorders; however, its influence on the lumbar muscle physiology is still poorly understood. The objective of this study was to investigate the effects of backrest support and hand grip contractions on lumbar muscle ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.033696
更新日期:2006-09-01 00:00:00
abstract::The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003879
更新日期:1995-09-01 00:00:00
abstract::Hypoxia has been reported to increase arterial potassium concentration ([K+]a) in anaesthetized cats (Paterson, Estavillo & Nye, 1988). The purpose of this study was to determine whether this phenomenon occurs in humans. The effect of hypoxia on [K+]a was measured in ten male subjects, at rest and during light exercis...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003759
更新日期:1994-03-01 00:00:00
abstract::In anaesthetized cats, it was possible to enhance the dynamic sensitivity to stretch of jaw muscle spindle primary afferents by electrical stimulation in the midbrain. This effect was taken to be due to excitation of dynamic fusimotor neurones and was used to identify fusimotor fibres as static or dynamic in recording...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003667
更新日期:1993-01-01 00:00:00
abstract::Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.065557
更新日期:2012-12-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2014.079525
更新日期:2015-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086871
更新日期:2018-08-01 00:00:00
abstract::Electromyographic recordings (EMGs) were made from the active masseter muscle, of the inhibitory reflex evoked by application of electrical stimuli to the skin of the upper lip in fifteen human subjects. In control sequences, the reflex had a mean latency of 42 +/- 1.1 ms and a mean duration of 45 +/- 2.1 ms. The magn...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003849
更新日期:1995-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is mesenchymal stem cell-conditioned medium capable of improving the pathological alterations of ovalbumin-induced asthma in mice? What is the main finding and its importance? Our study indicated that human amniotic membrane mesenchymal stem cell-conditioned medi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088911
更新日期:2020-12-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085420
更新日期:2016-03-01 00:00:00
abstract::What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085716
更新日期:2016-07-01 00:00:00
abstract::What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP085624
更新日期:2016-08-01 00:00:00
abstract::We investigated the permeability of Cs+ and Na+ through various ion channels in rat atrial myocytes using the whole-cell voltage-clamp technique. With isotonic CsCl (140 mM) on both sides of the membrane and nominally [Ca2+]o-free conditions, depolarising clamp pulses induced an increase of outward currents which show...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The application of the four main techniques available for examining the properties of alpha-adrenoceptors, gene coding, radioligand, biochemical and functional methods, has reinforced the earlier subclassification (alpha 1- and alpha 2-subtypes). These different techniques have not yet yielded subclassifications which...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.1991.sp003501
更新日期:1991-05-01 00:00:00
abstract::Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2004.027409
更新日期:2004-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.083139
更新日期:2015-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Are the urinary concentrations of NO and ATP, and their metabolites, associated with the severity of symptoms of overactive bladder? What is the main finding and its importance? The urinary ratios of [ATP/NO], [ADP/NO] and a combination of these, [ATP/Cr*ADP/Cr]/...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088450
更新日期:2020-06-01 00:00:00
abstract::This study investigated the role of nitric oxide (NO) and superoxide anions in modulating the renal nerve-dependent increases in proximal tubular fluid reabsorption (Jva). Renal nerve stimulation at 0.75 and 1.0 Hz (15 V, 0.2 ms) in anaesthetized Wistar rats had no effect on glomerular filtration rate but decreased ur...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2003.002640
更新日期:2004-05-01 00:00:00
abstract::An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzym...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003444
更新日期:1990-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088515
更新日期:2021-01-01 00:00:00