The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation.

abstract：NEW FINDINGS:What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and...

journal_title：Experimental physiology

authors： Oliveira LM,Oliveira MA,Moriya HT,Moreira TS,Takakura AC

更新日期：2019-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Glucose is the dominant energy source for the brain. However, little is known about how glucose metabolism impacts the coordination of network activity in the brain in healthy adults. What is the main finding and its importance? We demonstrate that both alpha osc...

journal_title：Experimental physiology

authors： Walker CP,Buse J,Frohlich F

更新日期：2021-01-28 00:00:00

abstract：:This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...

journal_title：Experimental physiology

authors： Iannitti T,Graham A,Dolan S

更新日期：2012-11-01 00:00:00

abstract：:This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and di...

journal_title：Experimental physiology

authors： Dawson EA,Shave R,Whyte G,Ball D,Selmer C,Jans Ø,Secher NH,George KP

更新日期：2007-03-01 00:00:00

abstract：:Ionic mechanisms and signal transduction underlying noradrenaline (NA)-induced depolarization in single smooth muscle cells of guinea-pig vas deferens were studied. NA caused depolarization followed by action potentials through activation of 1-adrenoceptors. In the presence of nifedipine, no action potential was gener...

journal_title：Experimental physiology

authors： Kamimura N,Suga S,Nakano K,Kanno T,Takeo T,Wakui M

更新日期：2000-01-01 00:00:00

abstract：:Pairs of Ia and II afferent fibres supplying primary and secondary endings lying in the same tenuissimus spindles were prepared in barbiturate anaesthetized cats in order to compare the variability in the rhythm of discharge of the two endings during responses elicited by the contraction of different intrafusal muscle...

journal_title：Experimental physiology

authors： Celichowski J,Emonet-Dénand F,Gladden M,Laporte Y,Petit J

更新日期：1994-09-01 00:00:00

abstract：:The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...

journal_title：Experimental physiology

authors： Van Obbergh L,Leonard V,Chen H,Xu D,Blaise G

更新日期：1995-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID) and th...

journal_title：Experimental physiology

authors： Subudhi AW,Evero O,Reitinger J,Davis C,Gronewold J,Nichols AJ,Van-Houten SJ,Roach RC

更新日期：2021-01-01 00:00:00

abstract：:This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented. Dogs were anaesthetised with -chloralose, artificially ventilated, the...

journal_title：Experimental physiology

authors： McMahon NC,Drinkhill MJ,Myers DS,Hainsworth R

更新日期：2000-07-01 00:00:00

abstract：:Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclea...

journal_title：Experimental physiology

authors： Potvin C,Rossignol O,Uppari N,Dallongeville A,Bairam A,Joseph V

更新日期：2014-11-01 00:00:00

abstract：:The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 weeks, using a rotat...

journal_title：Experimental physiology

authors： Rakobowchuk M,McGowan CL,de Groot PC,Bruinsma D,Hartman JW,Phillips SM,MacDonald MJ

更新日期：2005-07-01 00:00:00

abstract：:Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...

journal_title：Experimental physiology

authors： Smith MW,Phillips AD

更新日期：1990-07-01 00:00:00

abstract：:The spatiotemporal dynamics of intracellular calcium within the middle cerebral artery (MCA) isolated from stroke-prone spontaneously hypertensive rats (SHR-SP) were investigated using real-time confocal laser microscopy. At 3 months of age (prestroke), rhythmical changes in the [Ca(2+)](i) during the tonic phase were...

journal_title：Experimental physiology

authors： Hashimoto T,Kiya M,Ohata H,Miyazaki T,Shibata K,Nobe K,Honda K

更新日期：2012-02-01 00:00:00

abstract：:Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) ...

journal_title：Experimental physiology

authors： Porta C,James PS,Phillips AD,Savidge TC,Smith MW,Cremaschi D

更新日期：1992-11-01 00:00:00

abstract：:The pattern of propagation of slow waves in the small intestine is not clear. Specifically, it is not known whether propagation is determined by a single dominant ICC-MP (Interstitial cells of Cajal located in the Myenteric Plexus) pacemaker unit or whether there are multiple active pacemakers. To determine this patte...

journal_title：Experimental physiology

authors： Lammers WJ,Stephen B

更新日期：2008-03-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：:Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged physiological sodium deficiency in many animal species. The same neural mechanisms that are responsible for sodium appetite in laboratory animals may influence human behaviour as well, with particular relevance to the dietary salt intake...

journal_title：Experimental physiology

authors： Geerling JC,Loewy AD

更新日期：2008-02-01 00:00:00

abstract：:In this review we discuss our current understanding of the cellular basis of uterine contractility, highlighting those areas requiring further study. It is clear that the basic processes of excitation-contraction coupling lie within the myometrial cell, and that these may be modified by agonists. Pacemaker activity, h...

journal_title：Experimental physiology

authors： Wray S,Kupittayanant S,Shmygol A,Smith RD,Burdyga T

更新日期：2001-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inf...

journal_title：Experimental physiology

authors： Koyuncuoğlu T,Arabacı Tamer S,Erzik C,Karagöz A,Akakın D,Yüksel M,Yeğen BÇ

更新日期：2019-12-01 00:00:00

abstract：:Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormo...

journal_title：Experimental physiology

authors： Scott D,Loveridge N,Abu Damir H,Buchan W,Milne J

更新日期：1993-03-01 00:00:00

abstract：:Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...

journal_title：Experimental physiology

authors： Piskuric NA,Zhang M,Vollmer C,Nurse CA

更新日期：2014-01-01 00:00:00

abstract：:The hallmark of epithelial cells is their functional polarization. It is those membrane proteins that are distributed differentially, either to the apical or to the basal surface, that determine epithelial physiology. Such proteins will include 'pumps', 'channels' and 'carriers', and it is the functional interplay bet...

journal_title：Experimental physiology

authors： Boyd CA

更新日期：2008-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We examined whether the macrophage-synthesized antioxidant 7,8-dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8-dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction-ind...

journal_title：Experimental physiology

authors： Lindsay A,Schmiechen A,Chamberlain CM,Ervasti JM,Lowe DA

更新日期：2018-07-01 00:00:00

abstract：:The role of testosterone (T) in the regulation of cardiovascular function in females is not well understood. Our goal was to examine the effect of T on cardiomyocyte biology by measuring sarcomere shortening/relaxation and intracellular calcium cycling in adult female Sprague-Dawley rats. The rats were divided into th...

journal_title：Experimental physiology

authors： Beesley RD,Palmer BM,Casson PR,Toth MJ

更新日期：2013-01-01 00:00:00

abstract：:Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...

journal_title：Experimental physiology

authors： Shoemaker JK,Usselman CW,Rothwell A,Wong SW

更新日期：2012-12-01 00:00:00

abstract：:There is controversy about the effect of left ventricular pressure on resistance of the intramyocardial coronary vessels. In anaesthetized dogs the effect of left ventricular pressure on coronary flow during diastole was studied using an extracorporeal circulation and allowing the heart to contract and relax isovolumi...

journal_title：Experimental physiology

authors： Gattullo D,Linden RJ,Losano G,Pagliaro P,Westerhof N

更新日期：1992-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? One of the major unanswered questions in physiology is that of how breathing matches metabolic rate. Venous chemoreceptors seem to have been dismissed since the 1960s. What advances does it highlight? New evidence shows that their apparent dismissal needs reappraisal. The ...

journal_title：Experimental physiology

authors： Parkes MJ

更新日期：2017-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease is associated with systemic remodelling of the vascular tree remains unknown. The present study examined whether anatomical differences exist between distances of the intervisceral artery origins and ...

journal_title：Experimental physiology

authors： Bailey DM,Evans TG,Thomas KG,White RD,Twine CP,Lewis MH,Williams IM

更新日期：2016-08-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review is principally concerned with results from studies of the pulmonary vasculature in humans, particularly in relation to hypoxia and rare diseases that affect oxygen sensing. What advances does it highlight? This review highlights the degree to which the hypoxia-...

journal_title：Experimental physiology

authors： Frise MC,Robbins PA

更新日期：2015-11-01 00:00:00

abstract：:An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzym...

journal_title：Experimental physiology

authors： Pariente JA,Madrid JA,Salido GM

更新日期：1990-09-01 00:00:00