Abstract:
:Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormone (PTH) levels. Urinary cAMP excretion was unaffected by acid infusion. In separate experiments lambs made acidotic by feeding a diet containing NH4Cl were given infusions of PTH at the rate of 1 microgram/h. Infusion of the hormone was accompanied by a rise in plasma Ca and an increase rather than a decrease in urinary Ca excretion and no change in urinary cAMP excretion. These results point to the kidney as the primary site of response to acid loading in the lamb, a failure to reabsorb Ca in these conditions necessitating the release of PTH and an increase in bone resorption in order to maintain normal plasma Ca levels.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Scott D,Loveridge N,Abu Damir H,Buchan W,Milne Jdoi
10.1113/expphysiol.1993.sp003676subject
Has Abstractpub_date
1993-03-01 00:00:00pages
157-63issue
2eissn
0958-0670issn
1469-445Xjournal_volume
78pub_type
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