Abstract:
:In the present study, the ontogenic changes in gluconeogenic enzyme activities and in hepatic glycogen and beta-adrenergic receptor levels were investigated in fetal pigs from 70 days of gestation until delivery at term (114 +/- 2 days). The values were compared with those observed in fetuses infused subcutaneously with cortisol for 6 days beginning at 82-84 or 92-94 days of gestation. Tissue glucose-6-phosphatase (G6Pase) activity increased with increasing gestational age in the liver, kidney and duodenum of control fetal pigs. At birth, there was a further increase in G6Pase activity in the liver but not in the kidney or duodenum. In the kidney, there was a similar gestational increase in phosphoenolpyruvate carboxykinase (PEPCK) activity. These changes in enzyme activities closely paralleled the prepartum increase in fetal plasma cortisol and were accompanied by increases in hepatic glycogen content and beta-adrenergic receptor density. At 98-100 days, there were significant increases in G6Pase activity in the liver, kidney and duodenum of the cortisol-infused fetuses, whereas at 88-90 days only renal G6Pase was significantly elevated by cortisol infusion. Cortisol infusion also increased hepatic beta-receptor density at 88-90 days and hepatic glycogen content at both gestational ages. There were no changes in hepatic PEPCK, hepatic or renal fructose diphosphatase and aspartate amino transferase activities during cortisol infusion or with increasing gestational age. When the data from all the piglets were combined, irrespective of age or treatment, there were significant positive correlations between log plasma cortisol and G6Pase activity in the liver, kidney and duodenum. Similar positive correlations were observed between hepatic beta-adrenoceptor density and log plasma cortisol and between the latter values and the hepatic glycogen content. These findings show that cortisol induces tissue G6Pase activity in the fetal pig and suggest that the prepartum rise in endogenous cortisol may be responsible for the increase in fetal glucogenic capacity observed towards term in this as in other species.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Fowden AL,Apatu RS,Silver Mdoi
10.1113/expphysiol.1995.sp003860subject
Has Abstractpub_date
1995-05-01 00:00:00pages
457-67issue
3eissn
0958-0670issn
1469-445Xjournal_volume
80pub_type
杂志文章abstract::A considerable body of evidence indicates that the intracellular chloride concentration ([Cl-]i) is an important regulatory signal in epithelial ion transport. [Cl-]i regulates the open channel probability of sodium and chloride channels, the rate of chloride channel recycling to the apical membrane, cell volume homeo...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.031823
更新日期:2006-01-01 00:00:00
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journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1996.sp003940
更新日期:1996-05-01 00:00:00
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journal_title:Experimental physiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-09-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.080630
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1113/expphysiol.2011.061499
更新日期:2012-02-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP085129
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1113/EP087944
更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1113/EP085682
更新日期:2016-07-01 00:00:00
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journal_title:Experimental physiology
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doi:10.1113/EP086466
更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004131
更新日期:1998-07-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004151
更新日期:1998-09-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004084
更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003444
更新日期:1990-09-01 00:00:00
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
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更新日期:1990-05-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review is principally concerned with results from studies of the pulmonary vasculature in humans, particularly in relation to hypoxia and rare diseases that affect oxygen sensing. What advances does it highlight? This review highlights the degree to which the hypoxia-...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.068312
更新日期:2013-02-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070037
更新日期:2013-04-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086062
更新日期:2017-04-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1469-445x.2000.tb00011.x
更新日期:2000-03-01 00:00:00