Enhancement of mouse diaphragm contractility in the presence of antagonists of GABAA and GABAB receptors.

abstract：NEW FINDINGS:What is the central question of this study? Clinical studies suggest that obesity 'protects' against osteoporosis. However, these studies used only bone densitometry and assessed only one bone site, which is insufficient to enable conclusions to be drawn about the response of the whole skeleton. Furthermor...

journal_title：Experimental physiology

authors： Lacerda DR,Serakides R,de Melo Ocarino N,Ferreira AV,Moraes MM,Boeloni JN,Silva JF,de Oliveira MC,de Barcellos LA,Rodrigues LO,Soares DD

更新日期：2015-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do individuals with a patent foramen ovale (PFO+ ) have a larger alveolar-to-arterial difference in P O 2 ...

journal_title：Experimental physiology

authors： Duke JW,Beasley KM,Speros JP,Elliott JE,Laurie SS,Goodman RD,Futral E,Hawn JA,Lovering AT

更新日期：2020-09-01 00:00:00

abstract：:The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...

journal_title：Experimental physiology

authors： Hongo K,White E,Orchard CH

更新日期：1995-09-01 00:00:00

abstract：:Adenosine 5'-triphosphate (ATP) is a cotransmitter with classical transmitters in most nerves in the peripheral and central nervous systems, although the proportions vary between tissues and species and in different developmental and pathophysiological circumstances. There was early evidence that ATP was released toge...

journal_title：Experimental physiology

authors： Burnstock G

更新日期：2009-01-01 00:00:00

abstract：:Moderate-intensity endurance exercise training improves vascular endothelial vasomotor function; however, the impact of high-intensity exercise training has been equivocal. Thus, the effect of the physiological stress of the exercise remains poorly understood. Furthermore, enhanced vascular repair mediated by circulat...

journal_title：Experimental physiology

authors： Rakobowchuk M,Harris E,Taylor A,Baliga V,Cubbon RM,Rossiter HB,Birch KM

更新日期：2012-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

journal_title：Experimental physiology

authors： Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

更新日期：2016-03-01 00:00:00

abstract：:Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully eluci...

journal_title：Experimental physiology

authors： Torres-Andrade R,Moldenhauer R,Gutierrez-Bertín N,Soto-Covasich J,Mancilla-Medina C,Ehrenfeld C,Kerr B

更新日期：2014-09-01 00:00:00

abstract：:Effects of altered maternal salt intake between 122 and 127 days gestation (term is 150 days) were studied in eight fetuses carried by ewes which had renal insufficiency caused by subtotal nephrectomy (STNxF) and seven fetuses carried by intact ewes (IntF). Plasma sodium and osmolality were increased in ewes with subt...

journal_title：Experimental physiology

authors： Boyce AC,Gibson KJ,Thomson CL,Lumbers ER

更新日期：2008-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does hsa_circ_001653 influence the development of gastric cancer (GC) and if so how? What is the main finding and its importance? Bioinformatics analysis revealed the presence of differentially expressed hsa_circ_001653 in GC and adjacent normal tissues, and this...

journal_title：Experimental physiology

authors： Zhou W,Jiang R,Wang Y,Li Y,Sun Z,Zhao H

更新日期：2020-10-02 00:00:00

abstract：:To probe the mechanisms by which respiratory syncytial virus (RSV) infection in early life forms an important risk factor for the development of chronic asthma, an airway hyper-responsiveness (AHR) animal model of guinea-pigs with persistent RSV infection was established by intranasal instillation of 2 x 10(5) plaque-...

journal_title：Experimental physiology

authors： Tan Y,Yang T,Liu S,Liu H,Xiang Y,Qu F,Li H,Qin X

更新日期：2008-12-01 00:00:00

abstract：:Very brief and intense exercise triggers a biphasic metabolic and respiratory response with a second phase that occurs after the cessation of the muscular activity. The effects on minute ventilation (V(E)) produced by manipulation of the peripheral circulation in metabolically active muscles could thus be studied with...

journal_title：Experimental physiology

authors： Haouzi P,Chenuel B,Chalon B

更新日期：2001-11-01 00:00:00

abstract：:The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 weeks, using a rotat...

journal_title：Experimental physiology

authors： Rakobowchuk M,McGowan CL,de Groot PC,Bruinsma D,Hartman JW,Phillips SM,MacDonald MJ

更新日期：2005-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does recreational cold exposure result in cold sensitivity and is this associated with endothelial dysfunction and impaired sensory thermal thresholds? What is the main finding and its importance? Previous cold exposure was correlated with cold sensitivity of the...

journal_title：Experimental physiology

authors： Eglin CM,Costello JT,Tipton MJ,Massey H

更新日期：2021-01-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (+/- S.E.M.) of 2.4 +/- 0.4% as blood glucose le...

journal_title：Experimental physiology

authors： Puri BK,Lewis HJ,Saeed N,Davey NJ

更新日期：1999-01-01 00:00:00

abstract：:The aim of this study was to evaluate whether long-term administration of L-arginine, a physiological substrate for the production of nitric oxide, improved blood pressure, heart rate, cardiac hypertrophy and particularly structural changes in the coronary and carotid artery of spontaneously hypertensive rats (SHR). T...

journal_title：Experimental physiology

authors： Kristek F

更新日期：1998-09-01 00:00:00

abstract：:Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...

journal_title：Experimental physiology

authors： Holtenius K,Dahlborn K

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin sub...

journal_title：Experimental physiology

authors： Bányász T,Kovács T

更新日期：1998-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance? ENaC protein has an unexpected localization in the peripheral region of the apical membrane of bronchial ...

journal_title：Experimental physiology

authors： Musante I,Scudieri P,Venturini A,Guidone D,Caci E,Castellani S,Conese M,Galietta LJV

更新日期：2019-06-01 00:00:00

abstract：:In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...

journal_title：Experimental physiology

authors： Fowden AL,Forhead AJ

更新日期：2009-06-01 00:00:00

abstract：:Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...

journal_title：Experimental physiology

authors： Clapp LH,Gurney AM

更新日期：1991-09-01 00:00:00

abstract：:The neurohypophysial hormone vasopressin contributes to control of urine output and, while urine flow shows a clear daily rhythm, there has been debate as to whether this is true of neurohypophysial hormones. A study was performed on fifteen adult males, with a mean age of 25 years, over a 24 h period, nine blood samp...

journal_title：Experimental physiology

authors： Forsling ML,Montgomery H,Halpin D,Windle RJ,Treacher DF

更新日期：1998-05-01 00:00:00

abstract：:To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...

journal_title：Experimental physiology

authors： Layec G,Bringard A,Yashiro K,Le Fur Y,Vilmen C,Micallef JP,Perrey S,Cozzone PJ,Bendahan D

更新日期：2012-08-01 00:00:00

abstract：:What is the topic of this review? We review the current literature on the neural reflex termed the 'inflammatory reflex' that inhibits an excessive release of inflammatory mediators in response to an immune challenge. What advances does it highlight? The original model proposed that the inflammatory reflex is a vago-v...

journal_title：Experimental physiology

authors： Martelli D,Farmer DG,Yao ST

更新日期：2016-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Compared with Caucasians, African individuals are more susceptible to non-freezing cold injury and experience greater cutaneous vasoconstriction and cooler finger skin temperatures upon hand cooling. We investigated whether the enzyme cyclooxygenase is, in part, ...

journal_title：Experimental physiology

authors： Maley MJ,House JR,Tipton MJ,Eglin CM

更新日期：2017-07-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...

journal_title：Experimental physiology

authors： Toney GM,Pedrino GR,Fink GD,Osborn JW

更新日期：2010-05-01 00:00:00

abstract：:The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...

journal_title：Experimental physiology

authors： Peers C

更新日期：2004-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What factors influence the onset and magnitude of activation of the neck inspiratory muscles during inspiration? What is the main finding and its importance? Recruitment of the sternocleidomastoid and scalene muscles during inspiration, measured by means of surfa...

journal_title：Experimental physiology

authors： Washino S,Mankyu H,Kanehisa H,Mayfield DL,Cresswell AG,Yoshitake Y

更新日期：2019-04-01 00:00:00

abstract：:Ionic mechanisms and signal transduction underlying noradrenaline (NA)-induced depolarization in single smooth muscle cells of guinea-pig vas deferens were studied. NA caused depolarization followed by action potentials through activation of 1-adrenoceptors. In the presence of nifedipine, no action potential was gener...

journal_title：Experimental physiology

authors： Kamimura N,Suga S,Nakano K,Kanno T,Takeo T,Wakui M

更新日期：2000-01-01 00:00:00

abstract：:Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...

journal_title：Experimental physiology

authors： Kraniou GN,Cameron-Smith D,Hargreaves M

更新日期：2004-09-01 00:00:00