Abstract:
:The purpose of the present study was to investigate the effect of temperature on the rates of isometric force development and relaxation in electrically activated fresh and fatigued human adductor pollicis muscle. Following immersion of the lower arm for 20 min in water baths of four different temperatures, muscle temperatures were approximately 37, 31, 25 and 22 C. Maximal isometric force was reduced by 16.8 +/- 1.5 % at 22 C. The stimulation frequency-force and -rate of force development relationships were shifted to the left at lower temperatures. Q10 values for the maximal rates of force development and relaxation, and the times for 100 to 50 % and 50 to 25 % force relaxation, were about 2.0 between 37 and 25 C and about 3.8 between 25 and 22 C. However, the time for 50 to 25 % force relaxation had a relatively high Q10 value between 25 and 22 C (6.9) and this parameter also appeared to be more sensitive to fatigue compared to the other indices of relaxation. Nevertheless, the effect of fatigue on all parameters decreased with cooling over the entire (37-22 C) temperature range.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
de Ruiter CJ,Jones DA,Sargeant AJ,de Haan Adoi
10.1017/s0958067099018953subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1137-50issue
6eissn
0958-0670issn
1469-445Xpii
PHY_1895journal_volume
84pub_type
杂志文章abstract:NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086062
更新日期:2017-04-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Impairment and subsequent improvement in cerebral oxygenation during acute and prolonged exposure to high altitude affect exercise performance. This study innovates by investigating the effect of acute and prolonged high-altitude exposure on cerebral haemodynamic...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088354
更新日期:2021-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Non-invasive muscle function tests have not been validated for use in the study of muscle performance in high-fat-fed mice. What is the main finding and its importance? This study shows that grip strength, hang wire and four-limb hanging tests are able to discrim...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086328
更新日期:2017-07-01 00:00:00
abstract::The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2003.002657
更新日期:2004-01-01 00:00:00
abstract::Brain blood vessels contain muscarinic receptors that are important for cerebral blood flow (CBF) regulation, but whether a cholinergic receptor mechanism is involved in the exercise-induced increase in cerebral perfusion or affects cerebral metabolism remains unknown. We evaluated CBF and cerebral metabolism (from ar...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2010.054346
更新日期:2010-10-01 00:00:00
abstract::The effects of microinjections of adenosine and an adenosine receptor antagonist into the rostral ventrolateral medulla (RVLM) on the cardiovascular changes associated with the defence reaction were investigated in anaesthetized rats. Responses to electrical and chemical stimulation in RVLM were determined in alpha-ch...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1996.sp003919
更新日期:1996-01-01 00:00:00
abstract::Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.060491
更新日期:2012-01-01 00:00:00
abstract::The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003871
更新日期:1995-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Nerve growth factor (NGF) is reportedly a mediator inducing urinary bladder dysfunction. Is NGF directly involved in hyperexcitability of capsaicin-sensitive C-fibre bladder afferent pathways after spinal cord injury (SCI)? What is the main finding and its import...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086951
更新日期:2018-06-01 00:00:00
abstract::Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003745
更新日期:1994-01-01 00:00:00
abstract::Joint movement was recently shown to stimulate the secretion of the lubricant hyaluronan (HA); also, exercise therapy and intra-articular hyaluronan injections are used to treat moderate osteoarthritis. The present study quantifies the stimulus-response curves for HA secretion in vivo and reports a role of transcripti...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.045203
更新日期:2009-03-01 00:00:00
abstract::Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003385
更新日期:1990-01-01 00:00:00
abstract::There are abundant animal data attempting to identify the neural circuitry involved in cardiovascular control. Translating this research into humans has been made possible using functional neurosurgery during which deep brain stimulating electrodes are implanted into various brain nuclei for the treatment of chronic p...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2011.060848
更新日期:2012-01-01 00:00:00
abstract::This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.035089
更新日期:2007-03-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? Excitation-contraction coupling in fish hearts is maintained over a range of temperatures that would be cardioplegic to most mammals. Here, we review what is known about the fish cardiac ryanodine receptor, and consider how it may be regulated in a different manner from th...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP085136
更新日期:2015-12-01 00:00:00
abstract::We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.041285
更新日期:2008-07-01 00:00:00
abstract::A considerable body of evidence indicates that the intracellular chloride concentration ([Cl-]i) is an important regulatory signal in epithelial ion transport. [Cl-]i regulates the open channel probability of sodium and chloride channels, the rate of chloride channel recycling to the apical membrane, cell volume homeo...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.031823
更新日期:2006-01-01 00:00:00
abstract::We investigated the permeability of Cs+ and Na+ through various ion channels in rat atrial myocytes using the whole-cell voltage-clamp technique. With isotonic CsCl (140 mM) on both sides of the membrane and nominally [Ca2+]o-free conditions, depolarising clamp pulses induced an increase of outward currents which show...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::5-[5-(2-Nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (UCF-101) is a protease inhibitor which was reported to protect against ischaemic heart damage and apoptosis. This study evaluated the impact of UCF-101 on steptozotocin (STZ)-induced diabetic cardiomyocyte dysfunction. Adult FVB mice were made di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.049189
更新日期:2009-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do Fog2Rb-/Rb- mice present a defect of small intestine homeostasis? What is the main finding and its importance? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this intera...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087369
更新日期:2019-07-01 00:00:00
abstract::The glucagon response to insulin-induced hypoglycaemia was tested in rats that had been pinealectomised (Px), pinealectomised and fitted with melatonin implants (Px + MLT), or sham-operated (SO). The glucagon response to hypoglycaemia observed in SO rats (216 +/- 27 pg x ml(-1) at baseline versus 397 +/- 35 pg x ml(-1...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602205
更新日期:2001-09-01 00:00:00
abstract::Mechanical properties of the vascular smooth muscle from normal and dystrophin-deficient (mdx) mice were examined. Changes in resting and developed tensions in response to stretch were recorded in isolated portal vein. The vascular segments were elongated in 5 % increments of the 'in situ' length (Lr) up to 1.30Lr. Th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::The present study was designed to investigate the renal responses to hypotensive haemorrhage early in life and the role of renal sympathetic nerves in modulating these renal responses. To this end, experiments were carried out in conscious, chronically instrumented lambs with either intact renal nerves (n = 7, Intact)...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8702434
更新日期:2002-09-01 00:00:00
abstract::We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption ( ) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultras...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.062968
更新日期:2012-06-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease is associated with systemic remodelling of the vascular tree remains unknown. The present study examined whether anatomical differences exist between distances of the intervisceral artery origins and ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085804
更新日期:2016-08-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086846
更新日期:2018-08-01 00:00:00
abstract::Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003648
更新日期:1992-11-01 00:00:00
abstract::Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclea...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.080986
更新日期:2014-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does hsa_circ_001653 influence the development of gastric cancer (GC) and if so how? What is the main finding and its importance? Bioinformatics analysis revealed the presence of differentially expressed hsa_circ_001653 in GC and adjacent normal tissues, and this...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088399
更新日期:2020-10-02 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2014.079525
更新日期:2015-02-01 00:00:00