The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase.

abstract：:A recent model predicted a local synovial circulation of extravascular fluid in which capillary filtrate entered a joint cavity and fluid simultaneously drained out of the cavity via intercellular pathways distant from capillaries. Here, solutions of albumin (10-250 g l-1) were infused continuously into the knee joint...

journal_title：Experimental physiology

authors： McDonald JN,Levick JR

更新日期：1992-05-01 00:00:00

abstract：:Using the patch-clamp recording technique, we observed that endothelin-1 (ET-1; 0.8-16 nM) enhanced a voltage-activated outward current (Iout) and induced periodic oscillations of inward current in smooth muscle cells isolated from small pulmonary arteries (200-400 microns in diameter). Anion substitution experiments ...

journal_title：Experimental physiology

authors： Salter KJ,Turner JL,Albarwani S,Clapp LH,Kozlowski RZ

更新日期：1995-09-01 00:00:00

abstract：:Cessation of milk removal causes mammary tissue involution, which in rodents is characterized by extensive tissue degeneration and loss of the majority of luminal epithelial cells by apoptosis. In contrast, bovine mammary tissue shows little histological evidence of tissue remodelling between lactations. In this study...

journal_title：Experimental physiology

authors： Wilde CJ,Addey CV,Li P,Fernig DG

更新日期：1997-09-01 00:00:00

abstract：:Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...

journal_title：Experimental physiology

authors： Seitz MJ,Brown R,Macefield VG

更新日期：2013-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca(2+) and Ca(2+) entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. What is the main finding and its importanc...

journal_title：Experimental physiology

authors： Metzler-Wilson K,Sammons DL,Ossim MA,Metzger NR,Jurovcik AJ,Krause BA,Wilson TE

更新日期：2014-02-01 00:00:00

abstract：:All eukaryotic cells utilize oxidative phosphorylation to maintain their high-energy phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and cell survival is threatened when cells are deprived of O(2). Consequently, all cells have the ability to sense O(2), and to activate adaptive proce...

journal_title：Experimental physiology

authors： Guzy RD,Schumacker PT

更新日期：2006-09-01 00:00:00

abstract：:Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...

journal_title：Experimental physiology

authors： Najafipour H,Ferrell WR

更新日期：1994-01-01 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...

journal_title：Experimental physiology

authors： Wray S

更新日期：2015-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...

journal_title：Experimental physiology

authors： Manferdelli G,Marzorati M,Easton C,Porcelli S

更新日期：2021-01-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:Recently, we reported the presence of a local renal aldosterone production. In the present study, we tested the hypothesis that local aldosterone production in the kidney contributes to renal inflammation, matrix formation and albuminuria associated with diabetes. We evaluated changes in renal aldosterone content (RAC...

journal_title：Experimental physiology

authors： Siragy HM,Xue C

更新日期：2008-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...

journal_title：Experimental physiology

authors： Zhu Y,Wu Y,Yang L,Dou X,Jiang J,Wang L

更新日期：2019-06-01 00:00:00

abstract：:The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conve...

journal_title：Experimental physiology

authors： Kim CH,Rhee PL,Rhee JC,Kim YI,So I,Kim KW,Park MK,Uhm DY,Kang TM

更新日期：2000-09-01 00:00:00

abstract：:It is commonly stated that smell elicits a parotid salivary reflex in humans. However, this assumption seems to be supported only by experiments in which either a lemon or an irritating odour has been used as the primary stimulus. In this study six pleasant odours, chocolate, vanilla, peppermint, beef, tomato and lemo...

journal_title：Experimental physiology

authors： Lee VM,Linden RW

更新日期：1991-05-01 00:00:00

abstract：:This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

journal_title：Experimental physiology

authors： Buono MJ

更新日期：1999-03-01 00:00:00

abstract：:Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...

journal_title：Experimental physiology

authors： Clapp LH,Gurney AM

更新日期：1991-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of lncRNA PRRT3-AS1 in the regulation of peroxisome proliferator-activated receptor γ (PPARγ) gene-mediated mechanistic target of rapamycin (mTOR) signalling pathway in proliferation, apoptosis and autophagy of prostate cancer cells? What is the ...

journal_title：Experimental physiology

authors： Fan L,Li H,Wang W

更新日期：2020-05-01 00:00:00

abstract：:Mammalian cardiomyocytes have limited regenerative capacity, such that cell death can result in a net loss of viable contractile elements and a decrease in cardiac functional reserve, both during normal ageing and after insults to the myocardium leading to heart failure. At least four types of cell death have been des...

journal_title：Experimental physiology

authors： Goldspink DF,Burniston JG,Tan LB

更新日期：2003-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of miR-143-3p during human dental pulp stem cell (hDPSC) differentiation. What is the main finding and its importance? miR-143-3p negatively regulates receptor activator of nuclear factor-κB (RANK). RANK ligand (RANKL) binds to RANK and stimulate...

journal_title：Experimental physiology

authors： Yang C,Jia R,Zuo Q,Zheng Y,Wu Q,Luo B,Lin P,Yin L

更新日期：2020-05-01 00:00:00

abstract：:The dorsal horn of the spinal cord plays an important role in transmitting information from nociceptive primary afferent neurones to the brain; however, our knowledge of its neuronal and synaptic organisation is still limited. Nociceptive afferents terminate mainly in laminae I and II and some of these contain substan...

journal_title：Experimental physiology

authors： Todd AJ

更新日期：2002-03-01 00:00:00

abstract：:Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear. With or without adjustment for high-frequency (HF) power, total power or respiration,...

journal_title：Experimental physiology

authors： Goldstein DS,Bentho O,Park MY,Sharabi Y

更新日期：2011-12-01 00:00:00

abstract：:The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5...

journal_title：Experimental physiology

authors： Parrott RF,Ebenezer IS,Baldwin BA,Forsling ML

更新日期：1991-07-01 00:00:00

abstract：:Exposure to whole-body vibration is implicated as one of the occupational risk factors for lower back disorders; however, its influence on the lumbar muscle physiology is still poorly understood. The objective of this study was to investigate the effects of backrest support and hand grip contractions on lumbar muscle ...

journal_title：Experimental physiology

authors： Maikala RV,Bhambhani YN

更新日期：2006-09-01 00:00:00

abstract：:Indirect evidence supporting a solute-coupled liquid absorption from the pleural space of rabbits has recently been provided; moreover, the beta 2-adrenoceptor agonist terbutaline has been found to increase this absorption. In this study the effect of adrenaline and alpha-adrenoceptor agonists on net rate of liquid ab...

journal_title：Experimental physiology

authors： Zocchi L,Raffaini A,Agostoni E

更新日期：1997-05-01 00:00:00

abstract：:Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifical...

journal_title：Experimental physiology

authors： Padilla J,Jenkins NT,Roberts MD,Arce-Esquivel AA,Martin JS,Laughlin MH,Booth FW

更新日期：2013-01-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：:Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...

journal_title：Experimental physiology

authors： Shoemaker JK,Usselman CW,Rothwell A,Wong SW

更新日期：2012-12-01 00:00:00

abstract：:Sympathetic baroreflex sensitivity is increased during selective activation of the skeletal muscle metaboreflex with postexercise ischaemia (PEI) in young adults. However, to date, there are no data demonstrating this neural interaction between the arterial baroreflex and the muscle metaboreflex in healthy older adult...

journal_title：Experimental physiology

authors： Greaney JL,Schwartz CE,Edwards DG,Fadel PJ,Farquhar WB

更新日期：2013-10-01 00:00:00

abstract：:A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

journal_title：Experimental physiology

authors： Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

更新日期：1999-07-01 00:00:00