Programmed cell death in bovine mammary tissue during lactation and involution.

abstract：NEW FINDINGS:What is the central question of this study? What is the role of lncRNA PRRT3-AS1 in the regulation of peroxisome proliferator-activated receptor γ (PPARγ) gene-mediated mechanistic target of rapamycin (mTOR) signalling pathway in proliferation, apoptosis and autophagy of prostate cancer cells? What is the ...

journal_title：Experimental physiology

authors： Fan L,Li H,Wang W

更新日期：2020-05-01 00:00:00

abstract：:Beneficial effects of exercise training on the vasculature have been consistently reported in subjects with cardiovascular risk factors or disease, whereas studies in apparently healthy subjects have been less uniform. In this review, we examine evidence pertaining to the impact of exercise training on conduit and res...

journal_title：Experimental physiology

authors： Green DJ,Spence A,Halliwill JR,Cable NT,Thijssen DH

更新日期：2011-02-01 00:00:00

abstract：:The aim of the present work was to investigate the role of the serotoninergic system in the control of sodium appetite of hypothyroid rats (HTR) by administering drugs that affect the serotoninergic activity, and to compare the same homeostatic behaviour in euthyroid rats (ETR) also given these drugs. Fenfluramine (FE...

journal_title：Experimental physiology

authors： Badauê-Passos D Jr,Ventura RR,Silva LF,Olivares EL,Reis LC

更新日期：2003-03-01 00:00:00

abstract：:We have functionally expressed and identified a monocarboxylate transporter (MCT1) from rat jejunal enterocyte and we provide evidence for its basolateral localization. Poly(A)+ RNA isolated from rat jejunum was injected into Xenopus laevis oocytes and expression of a proton-lactate symporter was investigated by means...

journal_title：Experimental physiology

authors： Orsenigo MN,Tosco M,Bazzini C,Laforenza U,Faelli A

更新日期：1999-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The parasternal intercostal electromyogram (EMGpara) is known to provide an accurate, non-invasive index of respiratory load-capacity balance. Although relationships between EMGpara and both airflow obstruction and hyperinflation have been shown, the independent ...

journal_title：Experimental physiology

authors： MacBean V,Pringle CL,Lunt AC,Sharp KD,Ali A,Greenough A,Moxham J,Rafferty GF

更新日期：2017-04-01 00:00:00

abstract：:Tumour cell survival is intimately related to blood vessel function and so the tumour vasculature represents a novel target for cancer therapy. We have investigated a murine tumour model in which a metal clamp was used to occlude the vascular supply temporarily and then removed to allow reperfusion. This allows the st...

journal_title：Experimental physiology

authors： Parkins CS,Hill SA,Stratford MR,Dennis MF,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：:Previous studies have shown that prolactin administration to pregnant rats results in offspring with enhanced abundance of the brown adipose tissue-specific uncoupling protein (UCP) 1. The present study therefore aimed to determine whether a similar effect was observed after birth and if the sex of the animal further ...

journal_title：Experimental physiology

authors： Pearce S,Dieguez C,Gualillo O,Symonds ME,Stephenson T

更新日期：2003-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...

journal_title：Experimental physiology

authors： Lee GJ,Mossa-Al Hashimi L,Debnam ES,Unwin RJ,Marks J

更新日期：2017-04-01 00:00:00

abstract：:Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...

journal_title：Experimental physiology

authors： Najafipour H,Ferrell WR

更新日期：1994-01-01 00:00:00

abstract：:We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) H...

journal_title：Experimental physiology

authors： Mizuno M,Kawada T,Kamiya A,Miyamoto T,Shimizu S,Shishido T,Smith SA,Sugimachi M

更新日期：2010-09-01 00:00:00

abstract：:One of the most basic computational elements within a circuit is the synapse across which signals are transferred. Here we summarize some experimental strategies that allow the synaptic basis of circuit function to be studied through imaging. The two most promising approaches available currently are pHluorin-based rep...

journal_title：Experimental physiology

authors： Dreosti E,Lagnado L

更新日期：2011-01-01 00:00:00

abstract：:The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA responses to MI. In anaesthetized, open-chest male, female an...

journal_title：Experimental physiology

authors： Pinkham MI,Guild SJ,Malpas SC,Barrett CJ

更新日期：2012-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the main finding and its importance? The addition of a restitution period of 8 h after EPS induces the enlargement of human muscle cells...

journal_title：Experimental physiology

authors： Tarum J,Folkesson M,Atherton PJ,Kadi F

更新日期：2017-11-01 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent cells isolated from the inner cell mass of blastocysts. ES cells are able to differentiate into the three primitive layers (endoderm, mesoderm and ectoderm) of the organism, including the germline. To study early stages of development, as well as to investigate the impact of a...

journal_title：Experimental physiology

authors： Desbaillets I,Ziegler U,Groscurth P,Gassmann M

更新日期：2000-11-01 00:00:00

abstract：:A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...

journal_title：Experimental physiology

authors： Fowler MR,Hunter M

更新日期：2005-03-01 00:00:00

abstract：:Resting heart rate and heart rate variability of 33 postmenopausal women were compared with those of 50 premenopausal women of comparable activity level, none of whom had used hormone replacement therapy. Heart rate was measured as the mean of at least 600 consecutive R-R intervals obtained from electrocardiograph (EC...

journal_title：Experimental physiology

authors： Brockbank CL,Chatterjee F,Bruce SA,Woledge RC

更新日期：2000-05-01 00:00:00

abstract：:Mechanical properties of the vascular smooth muscle from normal and dystrophin-deficient (mdx) mice were examined. Changes in resting and developed tensions in response to stretch were recorded in isolated portal vein. The vascular segments were elongated in 5 % increments of the 'in situ' length (Lr) up to 1.30Lr. Th...

journal_title：Experimental physiology

authors： Mancinelli R,Tonali P,Romani R,Tringali A,Vargiu R,AZZENA GB

更新日期：1999-09-01 00:00:00

abstract：:Oxidants have been suggested to enhance contractile function in unfatigued muscle. In this study we aimed to determine the effect of oxidants on "chemically skinned" diaphragm muscle fibre bundles. The sarcoplasmic reticulum and contractile proteins were exposed to superoxide anions (O2-) and hydrogen peroxide (H2O2) ...

journal_title：Experimental physiology

authors： Darnley GM,Duke AM,Steele DS,MacFarlane NG

更新日期：2001-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does hsa_circ_001653 influence the development of gastric cancer (GC) and if so how? What is the main finding and its importance? Bioinformatics analysis revealed the presence of differentially expressed hsa_circ_001653 in GC and adjacent normal tissues, and this...

journal_title：Experimental physiology

authors： Zhou W,Jiang R,Wang Y,Li Y,Sun Z,Zhao H

更新日期：2020-10-02 00:00:00

abstract：:The objective of this study was to examine the potential of stearic acid to induce cardiomyocyte cell death and the hypothesis that the amount of cellular lipid is a determinant of cell death. In cardiomyocytes from embryonic chick heart, stearic acid (SA) produced a significant (P < 0.001) concentration-dependent inc...

journal_title：Experimental physiology

authors： Rabkin SW,Lodhia P

更新日期：2009-08-01 00:00:00

abstract：:The effects of two different feeding regimes on the 24 h profiles of maternal and fetal plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were studied in eight pregnant ewes between 123 and 144 days of gestation. Once daily-fed ewes (n = 4) received 1 kg of lucerne-chaff at 11.00 h, and multi-fed ...

journal_title：Experimental physiology

authors： Simonetta G,Walker DW,McMillen IC

更新日期：1991-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...

journal_title：Experimental physiology

authors： Yang K,Wang J,Lu W

更新日期：2017-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does short-term heat acclimation enhance whole-body evaporative heat loss and augment nitric oxide synthase (NOS)-dependent cutaneous vasodilatation and NOS- and cyclooxygenase (COX)-dependent sweating, in exercising older men? What is the main finding and its im...

journal_title：Experimental physiology

authors： Fujii N,McGarr GW,Notley SR,Boulay P,Sigal RJ,Amano T,Nishiyasu T,Poirier MP,Kenny GP

更新日期：2020-12-21 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...

journal_title：Experimental physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2015-02-01 00:00:00

abstract：:Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully eluci...

journal_title：Experimental physiology

authors： Torres-Andrade R,Moldenhauer R,Gutierrez-Bertín N,Soto-Covasich J,Mancilla-Medina C,Ehrenfeld C,Kerr B

更新日期：2014-09-01 00:00:00

abstract：:It is commonly stated that smell elicits a parotid salivary reflex in humans. However, this assumption seems to be supported only by experiments in which either a lemon or an irritating odour has been used as the primary stimulus. In this study six pleasant odours, chocolate, vanilla, peppermint, beef, tomato and lemo...

journal_title：Experimental physiology

authors： Lee VM,Linden RW

更新日期：1991-05-01 00:00:00

abstract：:The effects of microinjections of adenosine and an adenosine receptor antagonist into the rostral ventrolateral medulla (RVLM) on the cardiovascular changes associated with the defence reaction were investigated in anaesthetized rats. Responses to electrical and chemical stimulation in RVLM were determined in alpha-ch...

journal_title：Experimental physiology

authors： Thomas T,Spyer KM

更新日期：1996-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does baroreceptor unloading during passive hyperthermia contribute to increases in ventilation and decreases in end-tidal carbon dioxide during that exposure? What is the main finding and its importance? Hyperthermic hyperventilation is not mitigated by expanding...

journal_title：Experimental physiology

authors： Lucas RA,Pearson J,Schlader ZJ,Crandall CG

更新日期：2015-11-01 00:00:00