Abstract:
:We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) Hz(1); natural frequency, 0.07 +/- 0.03 Hz; damping coefficient, 1.96 +/- 0.64; and lag time, 0.73 +/- 0.12 s). The transfer function from vagal stimulation to HR response approximated a first-order, low-pass filter with a lag time (gain, 8.84 +/- 4.51 beats min(1) Hz(1); corner frequency, 0.12 +/- 0.06 Hz; and lag time, 0.12 +/- 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Mizuno M,Kawada T,Kamiya A,Miyamoto T,Shimizu S,Shishido T,Smith SA,Sugimachi Mdoi
10.1113/expphysiol.2010.053090subject
Has Abstractpub_date
2010-09-01 00:00:00pages
919-25issue
9eissn
0958-0670issn
1469-445Xpii
expphysiol.2010.053090journal_volume
95pub_type
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