Abstract:
:The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5 min but no change in cortisol concentrations. Intravenous injection of 0.7 and 1.3 micrograms/kg CCK initiated a rapid surge (within 2 min) in plasma vasopressin and a later increase in cortisol secretion. The time course of the vasopressin response to the central injection of CCK was found to be similar to the period of behavioural inhibition induced when an equivalent dose of the peptide was given by the same route in an earlier feeding experiment. An analogous situation was also observed when CCK was given peripherally and, in this case, the threshold dose at which the behavioural and endocrine responses were induced was found to be the same.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Parrott RF,Ebenezer IS,Baldwin BA,Forsling MLdoi
10.1113/expphysiol.1991.sp003518subject
Has Abstractpub_date
1991-07-01 00:00:00pages
525-31issue
4eissn
0958-0670issn
1469-445Xjournal_volume
76pub_type
杂志文章abstract::The aim of the present work was to investigate the role of the serotoninergic system in the control of sodium appetite of hypothyroid rats (HTR) by administering drugs that affect the serotoninergic activity, and to compare the same homeostatic behaviour in euthyroid rats (ETR) also given these drugs. Fenfluramine (FE...
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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更新日期:2000-01-01 00:00:00
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journal_title:Experimental physiology
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journal_title:Experimental physiology
pub_type: 杂志文章,评审
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更新日期:2015-04-20 00:00:00
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journal_title:Experimental physiology
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更新日期:1997-03-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
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