Evidence for simultaneous bidirectional fluid flux across synovial lining in knee joints of anaesthetized rabbits.

abstract：NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...

journal_title：Experimental physiology

authors： Mosca EV,Rousseau JP,Gulemetova R,Kinkead R,Wilson RJ

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Oestradiol (E2 ) plays an important role in regulating skeletal muscle strength in females. To what extent does E2 deficiency affect recovery of strength and satellite cell number when muscle is challenged by multiple injuries? What is the main finding and its im...

journal_title：Experimental physiology

authors： Larson AA,Baumann CW,Kyba M,Lowe DA

更新日期：2020-10-01 00:00:00

abstract：:The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2006-07-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

journal_title：Experimental physiology

authors： Silver J,Wadley G,Lamon S

更新日期：2018-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：:This study was designed to investigate the putative neurophysiological effects of so-called 'H-wave therapy' (HWT), a form of electrical stimulation, upon conduction latencies in the human superficial radial nerve. Antidromic compound action potentials were recorded from the superficial radial nerve in the dominant fo...

journal_title：Experimental physiology

authors： McDowell BC,Lowe AS,Walsh DM,Baxter GD,Allen JM

更新日期：1996-09-01 00:00:00

abstract：:The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...

journal_title：Experimental physiology

authors： Hongo K,White E,Orchard CH

更新日期：1995-09-01 00:00:00

abstract：:A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...

journal_title：Experimental physiology

authors： Fowler MR,Hunter M

更新日期：2005-03-01 00:00:00

abstract：:The objective of the experiments was to investigate the cellular basis of the inotropic effect on myocardium of several opioids which have been implicated in producing cardiotoxic effects in human poisoning. Opioids exerted negative inotropic effects, with half-maximal concentrations between 10 microM (dextropropoxyph...

journal_title：Experimental physiology

authors： Wu C,Fry CH,Henry J

更新日期：1997-03-01 00:00:00

abstract：:The aim of this study was to evaluate whether long-term administration of L-arginine, a physiological substrate for the production of nitric oxide, improved blood pressure, heart rate, cardiac hypertrophy and particularly structural changes in the coronary and carotid artery of spontaneously hypertensive rats (SHR). T...

journal_title：Experimental physiology

authors： Kristek F

更新日期：1998-09-01 00:00:00

abstract：:In humans, skeletal muscle blood flow is regulated by an interaction between several locally formed vasodilators, including NO and prostaglandins. In plasma, ATP is a potent vasodilator that stimulates the formation of NO and prostaglandins and, very importantly, can offset local sympathetic vasoconstriction. Adenosin...

journal_title：Experimental physiology

authors： Mortensen SP,Saltin B

更新日期：2014-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does treatment of obstructive sleep apnoea (OSA) with nocturnal oxygen or continuous positive airway pressure (CPAP) improve hypoxic vascular responses, which are reportedly impaired in OSA? What is the main finding and its importance? Cerebrovascular and cardiov...

journal_title：Experimental physiology

authors： Beaudin AE,Hanly PJ,Raneri JK,Sajobi TT,Anderson TJ,Poulin MJ

更新日期：2019-04-01 00:00:00

abstract：:The vascular actions of insulin are complex, because it can stimulate both nitric oxide-mediated dilatation and endothelin (ET)-1-mediated constriction. We examined vasoreactivity to insulin in isolated feed arteries of the gastrocnemius (GFA) and soleus muscles (SFA) of 32-week-old Long-Evans Tokushima Otsuka (LETO) ...

journal_title：Experimental physiology

authors： Jenkins NT,Padilla J,Martin JS,Crissey JM,Thyfault JP,Rector RS,Laughlin MH

更新日期：2014-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does recreational cold exposure result in cold sensitivity and is this associated with endothelial dysfunction and impaired sensory thermal thresholds? What is the main finding and its importance? Previous cold exposure was correlated with cold sensitivity of the...

journal_title：Experimental physiology

authors： Eglin CM,Costello JT,Tipton MJ,Massey H

更新日期：2021-01-01 00:00:00

abstract：:In order to investigate the effect of chronic sodium depletion on renal proximal tubular reabsorption, studies were performed in conscious, unrestrained Brattleboro rats. Since these animals lack circulating vasopressin, fractional water reabsorption in the distal nephron can be assumed to be constant and changes in u...

journal_title：Experimental physiology

authors： Shirley DG,Skinner J

更新日期：1994-03-01 00:00:00

abstract：:Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...

journal_title：Experimental physiology

authors： Shoemaker JK,Usselman CW,Rothwell A,Wong SW

更新日期：2012-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...

journal_title：Experimental physiology

authors： Oghbaei H,Alipour MR,Hamidian G,Ahmadi M,Ghorbanzadeh V,Keyhanmanesh R

更新日期：2018-12-01 00:00:00

abstract：:Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations in the dystrophin gene destroy the link between the internal muscle filaments and the extracellular matrix, resulting in severe muscle weakness and progressive muscle wasting. There is currently no cure and, whilst palliative treat...

journal_title：Experimental physiology

authors： Fairclough RJ,Bareja A,Davies KE

更新日期：2011-11-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the regulation of cerebral blood flow and metabolism during exercise from 1945 to the present day. What advances does it highlight? This article highlights the importance ...

journal_title：Experimental physiology

authors： Smith KJ,Ainslie PN

更新日期：2017-11-01 00:00:00

abstract：:The spatiotemporal dynamics of intracellular calcium within the middle cerebral artery (MCA) isolated from stroke-prone spontaneously hypertensive rats (SHR-SP) were investigated using real-time confocal laser microscopy. At 3 months of age (prestroke), rhythmical changes in the [Ca(2+)](i) during the tonic phase were...

journal_title：Experimental physiology

authors： Hashimoto T,Kiya M,Ohata H,Miyazaki T,Shibata K,Nobe K,Honda K

更新日期：2012-02-01 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...

journal_title：Experimental physiology

authors： Parsons SP,Huizinga JD

更新日期：2018-08-01 00:00:00

abstract：:This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and di...

journal_title：Experimental physiology

authors： Dawson EA,Shave R,Whyte G,Ball D,Selmer C,Jans Ø,Secher NH,George KP

更新日期：2007-03-01 00:00:00

abstract：:In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...

journal_title：Experimental physiology

authors： Fowden AL,Forhead AJ

更新日期：2009-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Are the urinary concentrations of NO and ATP, and their metabolites, associated with the severity of symptoms of overactive bladder? What is the main finding and its importance? The urinary ratios of [ATP/NO], [ADP/NO] and a combination of these, [ATP/Cr*ADP/Cr]/...

journal_title：Experimental physiology

authors： Firouzmand S,Young JS

更新日期：2020-06-01 00:00:00

abstract：:In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...

journal_title：Experimental physiology

authors： Hill-Venning C,Cottrell GA

更新日期：1992-11-01 00:00:00

abstract：:We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption ( ) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultras...

journal_title：Experimental physiology

authors： Richards JC,Crecelius AR,Kirby BS,Larson DG,Dinenno FA

更新日期：2012-06-01 00:00:00

abstract：:The effect of unilateral Achilles' tendon section on the soleus muscle of rabbits was examined after 2 and 4 weeks of unsutured recovery. Immobilization of the limb during recovery was also investigated. Following tendon section the limb was immobilized with an ankle angle of 90 deg, and final experiments were perform...

journal_title：Experimental physiology

authors： Barry JA,Cotter MA,Cameron NE,Pattullo MC

更新日期：1994-07-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...

journal_title：Experimental physiology

authors： Osborn JW,Hendel MD,Collister JP,Ariza-Guzman PA,Fink GD

更新日期：2012-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of the study? What are the effects of age and fitness on the vascular response to acute inflammation in younger and older adults? What is the main finding and its importance? In older adults, cardiorespiratory fitness level has a differential impact on endothelial function afte...

journal_title：Experimental physiology

authors： Schroeder EC,Lane-Cordova AD,Ranadive SM,Baynard T,Fernhall B

更新日期：2018-06-01 00:00:00