Abstract:
:There is controversy about the effect of left ventricular pressure on resistance of the intramyocardial coronary vessels. In anaesthetized dogs the effect of left ventricular pressure on coronary flow during diastole was studied using an extracorporeal circulation and allowing the heart to contract and relax isovolumically. At constant coronary perfusion pressure of about 45 mmHg with maximal coronary vasodilatation, produced by dipyridamole, increases in diastolic left ventricular pressure to 22 mmHg, producing a volume of 50 ml, did not affect diastolic coronary flow. It is suggested that in the intact animal over the physiological range of left ventricular diastolic pressure the resistance in the coronary vessels is not affected.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Gattullo D,Linden RJ,Losano G,Pagliaro P,Westerhof Ndoi
10.1113/expphysiol.1992.sp003602subject
Has Abstractpub_date
1992-03-01 00:00:00pages
397-400issue
2eissn
0958-0670issn
1469-445Xjournal_volume
77pub_type
杂志文章abstract::Severe-intensity constant-work-rate exercise results in the attainment of maximal oxygen uptake, but the muscle metabolic milieu at the limit of tolerance (T(lim)) for such exercise remains to be elucidated. We hypothesized that T(lim) during severe-intensity exercise would be associated with the attainment of consist...
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