Mechanism of pregnancy-induced attenuation of contraction to phenylephrine in rat aorta.

abstract：:We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

journal_title：Experimental physiology

authors： Cairns SP,Robinson DM,Loiselle DS

更新日期：2008-07-01 00:00:00

abstract：:We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) H...

journal_title：Experimental physiology

authors： Mizuno M,Kawada T,Kamiya A,Miyamoto T,Shimizu S,Shishido T,Smith SA,Sugimachi M

更新日期：2010-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...

journal_title：Experimental physiology

authors： Faller KM,McAndrew DJ,Schneider JE,Lygate CA

更新日期：2015-02-01 00:00:00

abstract：:In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...

journal_title：Experimental physiology

authors： Fowden AL,Forhead AJ

更新日期：2009-06-01 00:00:00

abstract：:Our aim was to analyse endothelial hypoxic preconditioning after hypoxia-reperfusion (HR). Endothelial functionality was analysed through the vasorelaxation responses to acetylcholine (Ach) and the level of serine1177 phosphorylated endothelial nitric oxide synthase (eNOS) (ser1177-eNOS) measured by Western blot in in...

journal_title：Experimental physiology

authors： Carrasco-Martín C,Alonso-Orgaz S,De la Pinta JC,Marques M,Macaya C,Barrientos A,González MM,García-Méndez A,Mateos-Cáceres PJ,Porres JC,Rico LA,López-Farré AJ

更新日期：2005-07-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...

journal_title：Experimental physiology

authors： Toney GM,Pedrino GR,Fink GD,Osborn JW

更新日期：2010-05-01 00:00:00

abstract：:Phosphoethanolamine and taurine have been identified in uterine extracts from rat and, for the first time, human tissue. The concentration of phosphoethanolamine [PEtn] determined by HPLC and 31P NMR spectroscopy, increased markedly (40%) within the first 6-12 h following parturition in rats, suggesting a role in invo...

journal_title：Experimental physiology

authors： Phoenix J,Wray S

更新日期：1994-07-01 00:00:00

abstract：:Cessation of milk removal causes mammary tissue involution, which in rodents is characterized by extensive tissue degeneration and loss of the majority of luminal epithelial cells by apoptosis. In contrast, bovine mammary tissue shows little histological evidence of tissue remodelling between lactations. In this study...

journal_title：Experimental physiology

authors： Wilde CJ,Addey CV,Li P,Fernig DG

更新日期：1997-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and...

journal_title：Experimental physiology

authors： Oliveira LM,Oliveira MA,Moriya HT,Moreira TS,Takakura AC

更新日期：2019-05-01 00:00:00

abstract：:The effect of the neuronal 5-HT3 receptor antagonist MDL 72222 has been investigated on the reflex tachypnoeic response to pulmonary embolism in pentobarbitone-anaesthetized rabbits. Pre-treatment with MDL 72222 (640 micrograms kg-1, 5 min prior to embolization) significantly attenuated the reflex tachypnoeic response...

journal_title：Experimental physiology

authors： Armstrong DJ,Kay IS

更新日期：1990-07-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...

journal_title：Experimental physiology

authors： Wray S

更新日期：2015-12-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：:Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...

journal_title：Experimental physiology

authors： Lesniewska V,Rowland I,Laerke HN,Grant G,Naughton PJ

更新日期：2006-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...

journal_title：Experimental physiology

authors： Braga VA,Soriano RN,Machado BH

更新日期：2006-11-01 00:00:00

abstract：:The effects of 5 weeks of moderate-intensity endurance training on pulmonary oxygen uptake kinetics (V(O(2)) on-kinetics) were studied in 15 healthy men (mean ± SD: age 22.7 ± 1.8 years, body weight 76.4 ± 8.9 kg and maximal V(O(2)) 46.0 ± 3.7 ml kg(-1) min(-1)). Training caused a significant acceleration (P = 0.003) ...

journal_title：Experimental physiology

authors： Zoladz JA,Grassi B,Majerczak J,Szkutnik Z,Korostyński M,Karasiński J,Kilarski W,Korzeniewski B

更新日期：2013-04-01 00:00:00

abstract：:Aldosterone influences the kidney's regulation of blood pressure (BP), but aldosterone can contribute to the pathogenesis of hypertension. Blood pressure is reduced with aerobic exercise training (AEX), but the extent to which plasma aldosterone (PA) levels change is unclear. The purpose of this study was to determine...

journal_title：Experimental physiology

authors： Jones JM,Dowling TC,Park JJ,Phares DA,Park JY,Obisesan TO,Brown MD

更新日期：2007-09-01 00:00:00

abstract：:Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units i...

journal_title：Experimental physiology

authors： Wallis WR,Wu C,Sheridan DJ,Fry CH

更新日期：1997-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...

journal_title：Experimental physiology

authors： Oghbaei H,Alipour MR,Hamidian G,Ahmadi M,Ghorbanzadeh V,Keyhanmanesh R

更新日期：2018-12-01 00:00:00

abstract：:The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conve...

journal_title：Experimental physiology

authors： Kim CH,Rhee PL,Rhee JC,Kim YI,So I,Kim KW,Park MK,Uhm DY,Kang TM

更新日期：2000-09-01 00:00:00

abstract：:The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position ju...

journal_title：Experimental physiology

authors： Ferrell WR,Crighton A,Sturrock RD

更新日期：1992-09-01 00:00:00

abstract：:Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...

journal_title：Experimental physiology

authors： Clapp LH,Gurney AM

更新日期：1991-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...

journal_title：Experimental physiology

authors： Spiller PF,da Silva CAA,Francescato HDC,Moraes DJA

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the effects of a 2 week period of severe food restriction on vascular reactivity of resistance arteries and on cardiac structure and function? What is the main finding and its importance? This study showed, for the first time, that a 2 week period of sev...

journal_title：Experimental physiology

authors： Almeida JFQ,Shults N,de Souza AMA,Ji H,Wu X,Woods J,Sandberg K

更新日期：2020-07-01 00:00:00

abstract：:Chronic heart failure (CHF) impairs muscle O2 delivery (QO2) and, at a given O2 uptake (VO2), lowers microvascular O2 pressures (PmvO2: determined by the QO2-to-VO2 ratio), which may impair recovery of high-energy phosphates following exercise. Because CHF preferentially decreases QO2 to slow-twitch muscles, we hypoth...

journal_title：Experimental physiology

authors： McDonough P,Behnke BJ,Musch TI,Poole DC

更新日期：2004-07-01 00:00:00

abstract：:We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption ( ) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultras...

journal_title：Experimental physiology

authors： Richards JC,Crecelius AR,Kirby BS,Larson DG,Dinenno FA

更新日期：2012-06-01 00:00:00

abstract：:Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large-animal-based model. The effect of chroni...

journal_title：Experimental physiology

authors： Gatford KL,De Blasio MJ,How TA,Harland ML,Summers-Pearce BL,Owens JA

更新日期：2012-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...

journal_title：Experimental physiology

authors： Zhu Y,Wu Y,Yang L,Dou X,Jiang J,Wang L

更新日期：2019-06-01 00:00:00

abstract：:Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifical...

journal_title：Experimental physiology

authors： Padilla J,Jenkins NT,Roberts MD,Arce-Esquivel AA,Martin JS,Laughlin MH,Booth FW

更新日期：2013-01-01 00:00:00

abstract：:The study examined the effect of salt-induced hypertension on vascular relaxation in response to magnesium sulphate during pregnancy. Pregnant Wistar rats were fed for 6 weeks on a diet containing 0.3% (control) and 8.0% (test) sodium chloride. Aortic rings were then removed and contracted with 10(-7) M phenylephrine ...

journal_title：Experimental physiology

authors： Aloamaka CP,Ezimokhai M,Osman NA,Morrison J

更新日期：1995-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Glucose is the dominant energy source for the brain. However, little is known about how glucose metabolism impacts the coordination of network activity in the brain in healthy adults. What is the main finding and its importance? We demonstrate that both alpha osc...

journal_title：Experimental physiology

authors： Walker CP,Buse J,Frohlich F

更新日期：2021-01-28 00:00:00