The role of carotid bodies in the generation of active inspiratory and expiratory responses to exercise in rats.

abstract：:Neuropeptides and regulatory peptide hormones control many developmental, physiological and behavioural processes in animals, including humans. The nonapeptides oxytocin and arginine vasopressin are produced and released by the pituitary gland and have actions on many organs and tissues. Receptive cells possess partic...

journal_title：Experimental physiology

authors： Gruber CW

更新日期：2014-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Oestradiol (E2 ) plays an important role in regulating skeletal muscle strength in females. To what extent does E2 deficiency affect recovery of strength and satellite cell number when muscle is challenged by multiple injuries? What is the main finding and its im...

journal_title：Experimental physiology

authors： Larson AA,Baumann CW,Kyba M,Lowe DA

更新日期：2020-10-01 00:00:00

abstract：:We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

journal_title：Experimental physiology

authors： Cairns SP,Robinson DM,Loiselle DS

更新日期：2008-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central goal of this study was to elucidate the role of magnesium in the regulation of pulmonary vascular reactivity in relationship to hypoxic pulmonary hypertension. What is the main finding and its importance? We found that magnesium is essential for norma...

journal_title：Experimental physiology

authors： Mu YP,Huang QH,Zhu JL,Zheng SY,Yan FR,Zhuang XL,Sham JSK,Lin MJ

更新日期：2018-04-01 00:00:00

abstract：:In anaesthetized cats, it was possible to enhance the dynamic sensitivity to stretch of jaw muscle spindle primary afferents by electrical stimulation in the midbrain. This effect was taken to be due to excitation of dynamic fusimotor neurones and was used to identify fusimotor fibres as static or dynamic in recording...

journal_title：Experimental physiology

authors： Donga R,Taylor A,Jüch PJ

更新日期：1993-01-01 00:00:00

abstract：:Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...

journal_title：Experimental physiology

authors： Kraniou GN,Cameron-Smith D,Hargreaves M

更新日期：2004-09-01 00:00:00

abstract：:This study was designed to investigate the putative neurophysiological effects of so-called 'H-wave therapy' (HWT), a form of electrical stimulation, upon conduction latencies in the human superficial radial nerve. Antidromic compound action potentials were recorded from the superficial radial nerve in the dominant fo...

journal_title：Experimental physiology

authors： McDowell BC,Lowe AS,Walsh DM,Baxter GD,Allen JM

更新日期：1996-09-01 00:00:00

abstract：:Age is a primary risk factor for cardiovascular disease, and this is an increasingly important public health concern because of an increase in the absolute number and proportion of the population at an older age in many countries. A key component of cardiovascular ageing is reduced function of the vascular endothelium...

journal_title：Experimental physiology

authors： Gates PE,Strain WD,Shore AC

更新日期：2009-03-01 00:00:00

abstract：:The inward transport of two purines, adenosine and hypoxanthine, at 37 degrees C by horse erythrocytes was compared. No mediated transport of adenosine was detected in horse erythrocytes, nor was saturable, high-affinity binding of the potent facilitated-diffusion inhibitor nitrobenzylthioinosine demonstrable in horse...

journal_title：Experimental physiology

authors： Jarvis SM,Harris RC

更新日期：1998-03-01 00:00:00

abstract：:We measured plasma levels of L-arginine, its analogue NG-monomethyl-L-arginine (L-NMMA), and related amino acids in normal subjects and uraemic patients (n = 31), before and after haemodialysis. Plasma levels of L-arginine were reduced to less than half of normal values in uraemic subjects compared with controls, and ...

journal_title：Experimental physiology

authors： Mendes Ribeiro AC,Roberts NB,Lane C,Yaqoob M,Ellory JC

更新日期：1996-05-01 00:00:00

abstract：:We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...

journal_title：Experimental physiology

authors： Best SA,Okada Y,Galbreath MM,Jarvis SS,Bivens TB,Adams-Huet B,Fu Q

更新日期：2014-06-01 00:00:00

abstract：:The renal medulla contains more mRNA of the inducible isoform of nitric oxide synthase (iNOS) than the cortex, which may be important in preventing ischaemic injury, since blood flow and tissue oxygen tension are normally low in this region. We examined the effects of the bacterial endotoxin E. coli lipopolysaccharide...

journal_title：Experimental physiology

authors： Chou DE,Cai H,Jayadevappa D,Porush JG

更新日期：2002-03-01 00:00:00

abstract：:Ageing is associated with skeletal muscle impairment. Changes in mitochondrial homeostasis are thought to play a key role in this process. This study examined whether chronic intake of polyphenols (PPs), which are known to be modulators of oxidative stress, might prevent the age-related decline of mitochondrial functi...

journal_title：Experimental physiology

authors： Charles AL,Meyer A,Dal-Ros S,Auger C,Keller N,Ramamoorthy TG,Zoll J,Metzger D,Schini-Kerth V,Geny B

更新日期：2013-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...

journal_title：Experimental physiology

authors： Yang K,Wang J,Lu W

更新日期：2017-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? The sympathetic control of renal sodium tubular reabsorption is dependent on activation of the intrarenal renin-angiotensin system and activation of the angiotensin II type 1 (AT1 ) receptor by angiotensin II. What advances does it highlight? Despite the fact that the inte...

journal_title：Experimental physiology

authors： Pontes RB,Girardi AC,Nishi EE,Campos RR,Bergamaschi CT

更新日期：2015-04-20 00:00:00

abstract：:Electromyographic recordings (EMGs) were made from the active masseter muscle, of the inhibitory reflex evoked by application of electrical stimuli to the skin of the upper lip in fifteen human subjects. In control sequences, the reflex had a mean latency of 42 +/- 1.1 ms and a mean duration of 45 +/- 2.1 ms. The magn...

journal_title：Experimental physiology

authors： Cadden SW,Newton JP

更新日期：1995-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review describes the role of renal nerves as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body. What advances does it highlight? Whether renal or autonomic ...

journal_title：Experimental physiology

authors： Nishi EE,Bergamaschi CT,Campos RR

更新日期：2015-04-20 00:00:00

abstract：:There are abundant animal data attempting to identify the neural circuitry involved in cardiovascular control. Translating this research into humans has been made possible using functional neurosurgery during which deep brain stimulating electrodes are implanted into various brain nuclei for the treatment of chronic p...

journal_title：Experimental physiology

authors： Basnayake SD,Green AL,Paterson DJ

更新日期：2012-01-01 00:00:00

abstract：:In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...

journal_title：Experimental physiology

authors： Fowden AL,Forhead AJ

更新日期：2009-06-01 00:00:00

abstract：:The properties of two types of calcium current (ICa(T) and ICa(L)) and their relationship with contraction were studied in isolated frog atrial trabeculae using the double mannitol gap technique. In Ringer solution containing TTX the calcium currents observed are similar to the ICa(T) and ICa(L) found in single frog a...

journal_title：Experimental physiology

authors： Badaoui A,Léoty C

更新日期：1994-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...

journal_title：Experimental physiology

authors： Lee GJ,Mossa-Al Hashimi L,Debnam ES,Unwin RJ,Marks J

更新日期：2017-04-01 00:00:00

abstract：:What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...

journal_title：Experimental physiology

authors： Prabhakar NR

更新日期：2016-08-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...

journal_title：Experimental physiology

authors： Iannitti T,Graham A,Dolan S

更新日期：2012-11-01 00:00:00

abstract：:A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistanc...

journal_title：Experimental physiology

authors： Barrett-O'Keefe Z,Kaplon RE,Halliwill JR

更新日期：2013-01-01 00:00:00

abstract：:Flow of submandibular saliva and the constituents secreted during chorda-lingual nerve stimulation at 40 Hz (3 x 10 min) were studied after alpha- and beta-adrenergic blockade, and in the absence (control) or presence of cholinergic blockade in anaesthetized rats. Peroxidase and true tissue kallikrein (rK1) were asses...

journal_title：Experimental physiology

authors： Garrett JR,Anderson LC,Zhang XS,Proctor GB

更新日期：1996-05-01 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the cellular and molecular determinants of increased risk for cardiovascular disease from prolonged sitting? What is the main finding and its importance? Prolonged sitting, independent of calf raise interruption strategies, decreases microparticle counts...

journal_title：Experimental physiology

authors： Evans WS,Hanson ED,Shill DD,Landers-Ramos RQ,Stoner L,Willey Q,Credeur DP,Prior SJ

更新日期：2020-08-01 00:00:00

abstract：:The present investigation was designed to examine whether calmodulin is involved in the inhibition of the ATP-sensitive K+ (K(ATP)) channel by glucagon-like peptide 1(7-36) amide (GLP-1) in mouse pancreatic beta-cells. Membrane potential, single channel and whole-cell currents through the K(ATP) channels, and intracel...

journal_title：Experimental physiology

authors： Ding WG,Kitasato H,Matsuura H

更新日期：2001-05-01 00:00:00

abstract：:Animal studies show that arginine vasopressin facilitates aggression, while serotonin (5-HT) inhibits aggression by blocking the activity of the vasopressin system. Clinical studies report that subjects with a history of 'fighting and assault' show a significant positive correlation between cerebrospinal fluid concent...

journal_title：Experimental physiology

authors： Ferris CF

更新日期：2000-03-01 00:00:00