Muscle afferent contributions to the cardiovascular response to isometric exercise.

abstract：:The effects of modification of the levels of endogenous plasma insulin on intestinal epithelial cell proliferation were investigated in rats maintained by total parenteral nutrition (TPN) using either a TPN diet that was high in glucose, or a low glucose (hypocaloric) TPN diet and in orally fed rats (normal and sham o...

journal_title：Experimental physiology

authors： Goodlad RA,Lee CY,Gilbey SG,Ghatei MA,Bloom SR

更新日期：1993-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...

journal_title：Experimental physiology

authors： Yang K,Wang J,Lu W

更新日期：2017-09-01 00:00:00

abstract：:Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...

journal_title：Experimental physiology

authors： Schmutz S,Däpp C,Wittwer M,Durieux AC,Mueller M,Weinstein F,Vogt M,Hoppeler H,Flück M

更新日期：2010-06-01 00:00:00

abstract：:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (...

journal_title：Experimental physiology

authors： Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

更新日期：1998-09-01 00:00:00

abstract：:To probe the mechanisms by which respiratory syncytial virus (RSV) infection in early life forms an important risk factor for the development of chronic asthma, an airway hyper-responsiveness (AHR) animal model of guinea-pigs with persistent RSV infection was established by intranasal instillation of 2 x 10(5) plaque-...

journal_title：Experimental physiology

authors： Tan Y,Yang T,Liu S,Liu H,Xiang Y,Qu F,Li H,Qin X

更新日期：2008-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Research has reported that some sensory input, such as auditory and olfactory input, can affect subliminal visual processing. However, it is important to address whether tactile input, another form of elementary sensory input, could influence the interocular riva...

journal_title：Experimental physiology

authors： Lang Y,Gao M,Huang Q,Liu Z,Wu L,Tang R

更新日期：2019-11-01 00:00:00

abstract：:Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...

journal_title：Experimental physiology

authors： Guth LM,Ludlow AT,Witkowski S,Marshall MR,Lima LC,Venezia AC,Xiao T,Ting Lee ML,Spangenburg EE,Roth SM

更新日期：2013-10-01 00:00:00

abstract：:Severe-intensity constant-work-rate exercise results in the attainment of maximal oxygen uptake, but the muscle metabolic milieu at the limit of tolerance (T(lim)) for such exercise remains to be elucidated. We hypothesized that T(lim) during severe-intensity exercise would be associated with the attainment of consist...

journal_title：Experimental physiology

authors： Vanhatalo A,Fulford J,DiMenna FJ,Jones AM

更新日期：2010-04-01 00:00:00

abstract：:Tumour cell survival is intimately related to blood vessel function and so the tumour vasculature represents a novel target for cancer therapy. We have investigated a murine tumour model in which a metal clamp was used to occlude the vascular supply temporarily and then removed to allow reperfusion. This allows the st...

journal_title：Experimental physiology

authors： Parkins CS,Hill SA,Stratford MR,Dennis MF,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of microRNA-424-5p (miR-424-5p) in aortic smooth muscle cells? How does miR-424-5p function as a suppressor of the inflammatory response? What is the main finding and its importance? Upregulation of miR-424-5p inhibits the inflammatory response i...

journal_title：Experimental physiology

authors： Li C,Zhang M,Dai Y,Xu Z

更新日期：2020-06-01 00:00:00

abstract：:This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

journal_title：Experimental physiology

authors： Buono MJ

更新日期：1999-03-01 00:00:00

abstract：:The role of bicarbonate as a hydrogen ion buffer has been investigated using the fluorescent dye BCECF in individual rat cerebellar, hippocampal and neocortical neurones maintained in culture. The steady-state intracellular pH (pHi) was estimated to be 7.07 +/- 0.05 (n = 22) in CO2-HCO3(-)-buffered media. Buffering po...

journal_title：Experimental physiology

authors： Amos BJ,Pocock G,Richards CD

更新日期：1996-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...

journal_title：Experimental physiology

authors： Zhu Y,Wu Y,Yang L,Dou X,Jiang J,Wang L

更新日期：2019-06-01 00:00:00

abstract：:Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...

journal_title：Experimental physiology

authors： Chan S,Head SI

更新日期：2011-06-01 00:00:00

abstract：:What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...

journal_title：Experimental physiology

authors： Prabhakar NR

更新日期：2016-08-01 00:00:00

abstract：:The effects of microinjections of adenosine and an adenosine receptor antagonist into the rostral ventrolateral medulla (RVLM) on the cardiovascular changes associated with the defence reaction were investigated in anaesthetized rats. Responses to electrical and chemical stimulation in RVLM were determined in alpha-ch...

journal_title：Experimental physiology

authors： Thomas T,Spyer KM

更新日期：1996-01-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:Recently attempts have been made to analyse blood pressure (BP) and renal sympathetic nerve activity (RSNA) to determine how patterns contained within them might reflect control by the autonomic nervous system. To date, these studies have primarily used coherence analysis of BP and RSNA in the frequency domain. Howeve...

journal_title：Experimental physiology

authors： Yang Z,Zhang T,Coote JH

更新日期：2002-07-01 00:00:00

abstract：:The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5...

journal_title：Experimental physiology

authors： Parrott RF,Ebenezer IS,Baldwin BA,Forsling ML

更新日期：1991-07-01 00:00:00

abstract：:The intrinsic proton buffering power (beta 1) of individual rat hippocampal and neocortical neurones maintained in culture has been investigated using the fluorescent dye 2', 7'-bis(carboxymethyl)-5, 6-(carboxyfluorescein) (BCECF). The steady-state intracellular pH (pH1) was estimated to be 7.03 +/- 0.04 (n = 22) in H...

journal_title：Experimental physiology

authors： Amos BJ,Richards CD

更新日期：1996-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Exertional heat stroke is accompanied by a marked inflammatory response. In this study, we explored the time course of acute phase proteins during recovery from severe heat stress in mice and the potential role of skeletal muscles as their source. What is the mai...

journal_title：Experimental physiology

authors： Iwaniec J,Robinson GP,Garcia CK,Murray KO,de Carvalho L,Clanton TL,Laitano O

更新日期：2021-01-01 00:00:00

abstract：:We have functionally expressed and identified a monocarboxylate transporter (MCT1) from rat jejunal enterocyte and we provide evidence for its basolateral localization. Poly(A)+ RNA isolated from rat jejunum was injected into Xenopus laevis oocytes and expression of a proton-lactate symporter was investigated by means...

journal_title：Experimental physiology

authors： Orsenigo MN,Tosco M,Bazzini C,Laforenza U,Faelli A

更新日期：1999-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does hsa_circ_001653 influence the development of gastric cancer (GC) and if so how? What is the main finding and its importance? Bioinformatics analysis revealed the presence of differentially expressed hsa_circ_001653 in GC and adjacent normal tissues, and this...

journal_title：Experimental physiology

authors： Zhou W,Jiang R,Wang Y,Li Y,Sun Z,Zhao H

更新日期：2020-10-02 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The aim was to determine the effect of mid-portion Achilles tendinopathy (MAT) on free Achilles tendon three-dimensional morphology and volume at rest and under load in people with unilateral MAT. What is the main finding and its importance? Tendinopathic tendon ...

journal_title：Experimental physiology

authors： Nuri L,Obst SJ,Newsham-West R,Barrett RS

更新日期：2018-03-01 00:00:00

abstract：:We investigated the permeability of Cs+ and Na+ through various ion channels in rat atrial myocytes using the whole-cell voltage-clamp technique. With isotonic CsCl (140 mM) on both sides of the membrane and nominally [Ca2+]o-free conditions, depolarising clamp pulses induced an increase of outward currents which show...

journal_title：Experimental physiology

authors： Youm JB,Ho WK,Earm YE

更新日期：2000-03-01 00:00:00

abstract：:Non-invasive autonomic evaluation has used fast Fourier transform (FFT) to assign a range of low (LF) and high frequencies (HF) as markers of sympathetic and parasympathetic influences, respectively. However, FFT cannot be applied to brief transient phenomena, such as those observed on performing autonomic tests where...

journal_title：Experimental physiology

authors： Ducla-Soares JL,Santos-Bento M,Laranjo S,Andrade A,Ducla-Soares E,Boto JP,Silva-Carvalho L,Rocha I

更新日期：2007-07-01 00:00:00

abstract：:Using the patch-clamp recording technique, we observed that endothelin-1 (ET-1; 0.8-16 nM) enhanced a voltage-activated outward current (Iout) and induced periodic oscillations of inward current in smooth muscle cells isolated from small pulmonary arteries (200-400 microns in diameter). Anion substitution experiments ...

journal_title：Experimental physiology

authors： Salter KJ,Turner JL,Albarwani S,Clapp LH,Kozlowski RZ

更新日期：1995-09-01 00:00:00

abstract：:Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (+/- S.E.M.) of 2.4 +/- 0.4% as blood glucose le...

journal_title：Experimental physiology

authors： Puri BK,Lewis HJ,Saeed N,Davey NJ

更新日期：1999-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...

journal_title：Experimental physiology

authors： Lee GJ,Mossa-Al Hashimi L,Debnam ES,Unwin RJ,Marks J

更新日期：2017-04-01 00:00:00