Bionic women and men - Part 1: Cardiovascular lessons from heart failure patients implanted with left ventricular assist devices.

abstract：:The renin-angiotensin system is activated in the early phase of two-kidney, one-clip (2K-1C) hypertension. The paraventricular nucleus (PVN) integrates inputs regulating sympathetic outflow. The PVN receives inputs from plasma angiotensin II via projections from circumventricular organs and from renal afferent nerves ...

journal_title：Experimental physiology

authors： Rossi NF,Maliszewska-Scislo M,Chen H,Black SM,Sharma S,Ravikov R,Augustyniak RA

更新日期：2010-08-01 00:00:00

abstract：:We have demonstrated that the fluorescent microsphere technique can be used in small mammals for accurate determination of regional blood flows. In particular we have shown that 100% recovery of trapped microspheres is possible, that tissue digestion can be completed in a shorter time than previously reported, and the...

journal_title：Experimental physiology

authors： Deveci D,Egginton S

更新日期：1999-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, with a prevalence of 8-12% during the reproductive years. In the present study, using prenatal exposure to a single dose of testosterone during the critical period of fetal development, we aimed to introduce an enhanced rat model ...

journal_title：Experimental physiology

authors： Tehrani FR,Noroozzadeh M,Zahediasl S,Piryaei A,Azizi F

更新日期：2014-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We modelled the alveolar pathway during breath holding on the hypothesis that it follows a hypoventilation loop on the O2 -CO2 diagram. What is the main finding and its importance? Validation of the model was possible within the range of alveolar gas compositions...

journal_title：Experimental physiology

authors： Taboni A,Fagoni N,Fontolliet T,Grasso GS,Moia C,Vinetti G,Ferretti G

更新日期：2020-09-29 00:00:00

abstract：:This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long-term exposure to seve...

journal_title：Experimental physiology

authors： Hoppeler H,Vogt M,Weibel ER,Flück M

更新日期：2003-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...

journal_title：Experimental physiology

authors： Spiller PF,da Silva CAA,Francescato HDC,Moraes DJA

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...

journal_title：Experimental physiology

authors： Lee GJ,Mossa-Al Hashimi L,Debnam ES,Unwin RJ,Marks J

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to assess the influence of body posture on post-submaximal exercise parasympathetic reactivation and to examine whether this influence was preserved under a heightened sympathetic background. On four occasions, eleven moderately trained subjects (22.1 +/- 3.0 years old) performed, in r...

journal_title：Experimental physiology

authors： Buchheit M,Al Haddad H,Laursen PB,Ahmaidi S

更新日期：2009-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Compared with Caucasians, African individuals are more susceptible to non-freezing cold injury and experience greater cutaneous vasoconstriction and cooler finger skin temperatures upon hand cooling. We investigated whether the enzyme cyclooxygenase is, in part, ...

journal_title：Experimental physiology

authors： Maley MJ,House JR,Tipton MJ,Eglin CM

更新日期：2017-07-01 00:00:00

abstract：:The endothelial glycocalyx layer of capillaries was stained with Ruthenium Red and examined by transmission electron microscopy in rat extensor hallucis proprius muscles after 2 or 4 days of indirect electrical stimulation via implanted electrodes. The layer appeared continuous on the luminal surface of 63% capillarie...

journal_title：Experimental physiology

authors： Brown MD,Egginton S,Hudlicka O,Zhou AL

更新日期：1996-11-01 00:00:00

abstract：:The effect of unilateral Achilles' tendon section on the soleus muscle of rabbits was examined after 2 and 4 weeks of unsutured recovery. Immobilization of the limb during recovery was also investigated. Following tendon section the limb was immobilized with an ankle angle of 90 deg, and final experiments were perform...

journal_title：Experimental physiology

authors： Barry JA,Cotter MA,Cameron NE,Pattullo MC

更新日期：1994-07-01 00:00:00

abstract：:Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial coll...

journal_title：Experimental physiology

authors： Madeddu P

更新日期：2005-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inf...

journal_title：Experimental physiology

authors： Koyuncuoğlu T,Arabacı Tamer S,Erzik C,Karagöz A,Akakın D,Yüksel M,Yeğen BÇ

更新日期：2019-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We investigated whether 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) could prevent acute increases in body fat and changes in omental and subcutaneous adipose tissue following the sudden transition from physical activity to physical inactivity. ...

journal_title：Experimental physiology

authors： Ruegsegger GN,Sevage JA,Childs TE,Grigsby KB,Booth FW

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the cellular and molecular determinants of increased risk for cardiovascular disease from prolonged sitting? What is the main finding and its importance? Prolonged sitting, independent of calf raise interruption strategies, decreases microparticle counts...

journal_title：Experimental physiology

authors： Evans WS,Hanson ED,Shill DD,Landers-Ramos RQ,Stoner L,Willey Q,Credeur DP,Prior SJ

更新日期：2020-08-01 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：:This study investigated the role of nitric oxide (NO) and superoxide anions in modulating the renal nerve-dependent increases in proximal tubular fluid reabsorption (Jva). Renal nerve stimulation at 0.75 and 1.0 Hz (15 V, 0.2 ms) in anaesthetized Wistar rats had no effect on glomerular filtration rate but decreased ur...

journal_title：Experimental physiology

authors： Wu XC,Johns EJ

更新日期：2004-05-01 00:00:00

abstract：:It is unclear whether cardiac hypertrophy and hypertrophy-related pathways will be induced by long-term intermittent hypoxia. Thirty-six Sprague-Dawley rats were randomly assigned into three groups: normoxia, and long-term intermittent hypoxia (12% O(2), 8 h per day) for 4 weeks (4WLTIH) or for 8 weeks (8WLTIH). Myoca...

journal_title：Experimental physiology

authors： Chen LM,Kuo WW,Yang JJ,Wang SG,Yeh YL,Tsai FJ,Ho YJ,Chang MH,Huang CY,Lee SD

更新日期：2007-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This brief review discusses potential sex differences in arterial function across the age span, with special emphasis on the effects of oestrogen and testosterone on the vascular endothelium. What advances does it highlight? We discuss the relationship between the impacts ...

journal_title：Experimental physiology

authors： Green DJ,Hopkins ND,Jones H,Thijssen DH,Eijsvogels TM,Yeap BB

更新日期：2016-02-01 00:00:00

abstract：:The cardiovascular response to isometric exercise is governed by both central and peripheral mechanisms. Both metabolic and mechanical stresses on the exercising skeletal muscle produce cardiovascular change, yet it is often overlooked that the afferent signal arising from the muscle can be modified by factors other t...

journal_title：Experimental physiology

authors： Fisher JP,White MJ

更新日期：2004-11-01 00:00:00

abstract：:Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...

journal_title：Experimental physiology

authors： Thwaites DT,Stevens BC

更新日期：1999-03-01 00:00:00

abstract：:Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...

journal_title：Experimental physiology

authors： Chan S,Head SI

更新日期：2011-06-01 00:00:00

abstract：:The nucleus tractus solitarii (NTS) is a key central link in control of multiple homeostatic reflexes. A number of studies have demonstrated that exogenous and endogenous nitric oxide (NO) within NTS regulates visceral function, but further understanding of the role of NO in the NTS is hampered by the lack of informat...

journal_title：Experimental physiology

authors： Wang S,Paton JF,Kasparov S

更新日期：2007-03-01 00:00:00

abstract：:Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...

journal_title：Experimental physiology

authors： Osborn JW,Averina VA,Fink GD

更新日期：2009-04-01 00:00:00

abstract：:Three experiments were performed to see whether cardiac neurons contribute to the intrinsic control of heart rate in right atria of adult rats. The intrinsic heart rate response (IRR) was examined by raising right atrial pressure from 2 to 8 mmHg for 3 min. In isolated preparations of the right atrium, the IRR was not...

journal_title：Experimental physiology

authors： Wilson SJ,Bolter CP

更新日期：2002-11-01 00:00:00

abstract：:A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

journal_title：Experimental physiology

authors： Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

更新日期：1999-07-01 00:00:00

abstract：:The effects of muscle fatigue on the mechanical efficiency of muscle work performance were studied in situ, in stretch-shortening cycles that resembled physiological conditions. The experiments were performed on the medial gastrocnemius muscles of seven rats. To calculate efficiency, a simple Hill-type model was used,...

journal_title：Experimental physiology

authors： Ettema GJ

更新日期：1997-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Quantitative values of shear rate-specific blood viscosity and shear stress in the human macrovasculature in response to exercise hyperaemia are unknown. What is the main finding and its importance? Using the handgrip exercise model, we showed that an increase in...

journal_title：Experimental physiology

authors： Leo JA,Simmonds MJ,Sabapathy S

更新日期：2020-02-01 00:00:00

abstract：:The resonant frequency of the wrist has been measured in sixteen hypermobile and nine normal women at ten levels of peak torque. At the lowest level the results were identical but at the others the hypermobile values were lower. Damping and thixotropy appeared to be normal. In another group the grip strength of hyperm...

journal_title：Experimental physiology

authors： Walsh EG,Lambert M,Wright GW,Powers N,Nuki G

更新日期：1991-03-01 00:00:00

abstract：:The intrinsic proton buffering power (beta 1) of individual rat hippocampal and neocortical neurones maintained in culture has been investigated using the fluorescent dye 2', 7'-bis(carboxymethyl)-5, 6-(carboxyfluorescein) (BCECF). The steady-state intracellular pH (pH1) was estimated to be 7.03 +/- 0.04 (n = 22) in H...

journal_title：Experimental physiology

authors： Amos BJ,Richards CD

更新日期：1996-03-01 00:00:00