Dietary salt-loading attenuates endothelium-dependent relaxation in response to histamine but not to acetylcholine in rat aortic rings.

abstract：NEW FINDINGS:What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the regulation of cerebral blood flow and metabolism during exercise from 1945 to the present day. What advances does it highlight? This article highlights the importance ...

journal_title：Experimental physiology

authors： Smith KJ,Ainslie PN

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...

journal_title：Experimental physiology

authors： Spiller PF,da Silva CAA,Francescato HDC,Moraes DJA

更新日期：2020-08-01 00:00:00

abstract：:This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented. Dogs were anaesthetised with -chloralose, artificially ventilated, the...

journal_title：Experimental physiology

authors： McMahon NC,Drinkhill MJ,Myers DS,Hainsworth R

更新日期：2000-07-01 00:00:00

abstract：:Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...

journal_title：Experimental physiology

authors： Seitz MJ,Brown R,Macefield VG

更新日期：2013-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Loss of taste or inability to distinguish between different tastes progresses with age. The purpose was to evaluate the age-dependent changes in taste by studying the electrophysiological properties of taste receptor cells. What is the main finding and its import...

journal_title：Experimental physiology

authors： Takeuchi K,Yoshii K,Ohtubo Y

更新日期：2020-11-10 00:00:00

abstract：:Converging lines of evidence from epidemiological studies and animal models now indicate that the origins of obesity and related metabolic disorders lie not only in the interaction between genes and traditional adult risk factors, such as unbalanced diet and physical inactivity, but also in the interplay between genes...

journal_title：Experimental physiology

authors： Taylor PD,Poston L

更新日期：2007-03-01 00:00:00

abstract：:Hypoxia has been reported to increase arterial potassium concentration ([K+]a) in anaesthetized cats (Paterson, Estavillo & Nye, 1988). The purpose of this study was to determine whether this phenomenon occurs in humans. The effect of hypoxia on [K+]a was measured in ten male subjects, at rest and during light exercis...

journal_title：Experimental physiology

authors： Barlow CW,Qayyum MS,Davey PP,Paterson DJ,Robbins PA

更新日期：1994-03-01 00:00:00

abstract：:This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

journal_title：Experimental physiology

authors： Buono MJ

更新日期：1999-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

journal_title：Experimental physiology

authors： Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

更新日期：2016-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...

journal_title：Experimental physiology

authors： Au JS,Bochnak PA,Valentino SE,Cheng JL,Stöhr EJ,MacDonald MJ

更新日期：2018-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the muscle metaboreflex affect the ratio of left ventricular contraction/relaxation rates and does heart failure impact this relationship. What is the main finding and its importance? The effect of muscle metaboreflex activation on the ventricular relaxation...

journal_title：Experimental physiology

authors： Mannozzi J,Massoud L,Kaur J,Coutsos M,O'Leary DS

更新日期：2020-11-23 00:00:00

abstract：:Recently, we reported the presence of a local renal aldosterone production. In the present study, we tested the hypothesis that local aldosterone production in the kidney contributes to renal inflammation, matrix formation and albuminuria associated with diabetes. We evaluated changes in renal aldosterone content (RAC...

journal_title：Experimental physiology

authors： Siragy HM,Xue C

更新日期：2008-07-01 00:00:00

abstract：:Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...

journal_title：Experimental physiology

authors： Guth LM,Ludlow AT,Witkowski S,Marshall MR,Lima LC,Venezia AC,Xiao T,Ting Lee ML,Spangenburg EE,Roth SM

更新日期：2013-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We modelled the alveolar pathway during breath holding on the hypothesis that it follows a hypoventilation loop on the O2 -CO2 diagram. What is the main finding and its importance? Validation of the model was possible within the range of alveolar gas compositions...

journal_title：Experimental physiology

authors： Taboni A,Fagoni N,Fontolliet T,Grasso GS,Moia C,Vinetti G,Ferretti G

更新日期：2020-09-29 00:00:00

abstract：:In quiescent papillary muscles isolated from hearts of rats with streptozotocin-induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both grou...

journal_title：Experimental physiology

authors： Lagadic-Gossmann D,Feuvray D

更新日期：1991-01-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...

journal_title：Experimental physiology

authors： Osborn JW,Hendel MD,Collister JP,Ariza-Guzman PA,Fink GD

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to evaluate whether long-term administration of L-arginine, a physiological substrate for the production of nitric oxide, improved blood pressure, heart rate, cardiac hypertrophy and particularly structural changes in the coronary and carotid artery of spontaneously hypertensive rats (SHR). T...

journal_title：Experimental physiology

authors： Kristek F

更新日期：1998-09-01 00:00:00

abstract：:The aim of the present study was to assess the influence of body posture on post-submaximal exercise parasympathetic reactivation and to examine whether this influence was preserved under a heightened sympathetic background. On four occasions, eleven moderately trained subjects (22.1 +/- 3.0 years old) performed, in r...

journal_title：Experimental physiology

authors： Buchheit M,Al Haddad H,Laursen PB,Ahmaidi S

更新日期：2009-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...

journal_title：Experimental physiology

authors： Oghbaei H,Alipour MR,Hamidian G,Ahmadi M,Ghorbanzadeh V,Keyhanmanesh R

更新日期：2018-12-01 00:00:00

abstract：:Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...

journal_title：Experimental physiology

authors： Lesniewska V,Rowland I,Laerke HN,Grant G,Naughton PJ

更新日期：2006-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...

journal_title：Experimental physiology

authors： Reynolds LJ,Chavan NR,DeHoff LB,Preston JD,Maddox HF,O'Brien JM,Armstrong DA,Marsit CJ,Pearson KJ

更新日期：2019-01-01 00:00:00

abstract：:In vivo microperfusion techniques were used to investigate the role of Na+-H+ exchange in the efferent ducts of the rat. Individual efferent ducts were perfused with a Krebs-Ringer bicarbonate solution (KRB) containing 0, 1, 3, 5 or 7.5 mM amiloride. Concentrations of 1-5 mM amiloride inhibited fluid reabsorption from...

journal_title：Experimental physiology

authors： Hansen LA,Clulow J,Jones RC

更新日期：1999-05-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of temperature on the rates of isometric force development and relaxation in electrically activated fresh and fatigued human adductor pollicis muscle. Following immersion of the lower arm for 20 min in water baths of four different temperatures, muscle tem...

journal_title：Experimental physiology

authors： de Ruiter CJ,Jones DA,Sargeant AJ,de Haan A

更新日期：1999-11-01 00:00:00

abstract：:Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...

journal_title：Experimental physiology

authors： Smith MW,Phillips AD

更新日期：1990-07-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is mesenchymal stem cell-conditioned medium capable of improving the pathological alterations of ovalbumin-induced asthma in mice? What is the main finding and its importance? Our study indicated that human amniotic membrane mesenchymal stem cell-conditioned medi...

journal_title：Experimental physiology

authors： Dalouchi F,Falak R,Bakhshesh M,Sharifiaghdam Z,Azizi Y,Aboutaleb N

更新日期：2020-12-01 00:00:00

abstract：:After 2 months of streptozotocin-induced diabetes in rats, the membrane potential of the diaphragm muscle when measured in vitro at 30 degrees C was unchanged but the tetanic tension, the half-relaxation time of the isometric twitch and the fatigue resistance were each reduced. Treatment of the diabetic rats with the ...

journal_title：Experimental physiology

authors： McGuire M,MacDermott M

更新日期：1998-07-01 00:00:00

abstract：:The application of the four main techniques available for examining the properties of alpha-adrenoceptors, gene coding, radioligand, biochemical and functional methods, has reinforced the earlier subclassification (alpha 1- and alpha 2-subtypes). These different techniques have not yet yielded subclassifications which...

journal_title：Experimental physiology

authors： Wilson VG,Brown CM,McGrath JC

更新日期：1991-05-01 00:00:00

abstract：:The uptake and distribution of CO throughout the circulatory system during two different methods of CO rebreathing (2 min 'Schmidt' and 40 min 'Burge' methods) were determined in nine healthy volunteers. Specifically, the impact of (i) differences in circulatory mixing time (t(mix)), (ii) CO diffusion to myoglobin (Mb...

journal_title：Experimental physiology

authors： Garvican LA,Burge CM,Cox AJ,Clark SA,Martin DT,Gore CJ

更新日期：2010-12-01 00:00:00

abstract：:Experiments were performed to investigate the presence and nature of beta-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to v...

journal_title：Experimental physiology

authors： Najafipour H,Ferrell WR

更新日期：1993-09-01 00:00:00