Sympathetic innervation and beta-adrenoceptor profile of blood vessels in the posterior region of the rabbit knee joint.

Abstract:

:Experiments were performed to investigate the presence and nature of beta-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to vasodilatation with administration of the alpha-adrenoceptor antagonist phenoxybenzamine. In almost all animals close intra-arterial injection of the beta-adrenoceptor agonist isoprenaline resulted in vasodilatation. Injection of the more selective beta-agonists dobutamine, salbutamol and terbutaline also produced vasodilatation with a rank potency order of isoprenaline > dobutamine > salbutamol > or = terbutaline. The beta-adrenoceptor antagonist propranolol abolished the dilator responses to adrenaline and isoprenaline, and significantly reduced the dilator responses to PAN stimulation in phenoxybenzamine-treated animals. Nerve-mediated vasodilatation was also reduced by the substance P antagonist D-Pro4 D-Trp7,9,10 SP4-11, suggesting that substance P contributes to this dilatation. Dobutamine, a selective beta 1-agonist, produced vasodilatation which was abolished by administration of the selective beta 1-antagonist atenolol. Isoprenaline-induced vasodilatation was substantially reduced by atenolol. The dilator response to isoprenaline appeared to be unaffected by the selective beta 2-antagonist ICI118551, but the weak dilator responses to the selective beta 2-agonists salbutamol and terbutaline were significantly reduced by this antagonist. The results of this study suggest that beta-adrenoceptors appear to be involved in the sympathetic regulation of rabbit knee joint blood flow, and that this is predominantly mediated via beta 1-adrenoceptors.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Najafipour H,Ferrell WR

doi

10.1113/expphysiol.1993.sp003711

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

625-37

issue

5

eissn

0958-0670

issn

1469-445X

journal_volume

78

pub_type

杂志文章
  • Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischaemic preconditioning.

    abstract::This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2012.066217

    authors: Donato M,Buchholz B,Rodríguez M,Pérez V,Inserte J,García-Dorado D,Gelpi RJ

    更新日期:2013-02-01 00:00:00

  • The mechanism of relaxation in response to magnesium by the aorta of pregnant rats with salt-induced hypertension.

    abstract::The study examined the effect of salt-induced hypertension on vascular relaxation in response to magnesium sulphate during pregnancy. Pregnant Wistar rats were fed for 6 weeks on a diet containing 0.3% (control) and 8.0% (test) sodium chloride. Aortic rings were then removed and contracted with 10(-7) M phenylephrine ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1995.sp003836

    authors: Aloamaka CP,Ezimokhai M,Osman NA,Morrison J

    更新日期:1995-01-01 00:00:00

  • A faster twitch contraction of soleus in the spontaneously hypertensive rat is partly due to changed fibre type composition.

    abstract::Contractile properties and fibre type composition of slow-twitch soleus muscles from spontaneously hypertensive rats (SHR) were compared with those from a control normotensive strain (Wistar-Kyoto, WKY). Male rats aged around 100 days were used, and muscle tension was recorded isometrically in vitro. Tetanic tension w...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1994.sp003772

    authors: Lewis DM,Levi AJ,Brooksby P,Jones JV

    更新日期:1994-05-01 00:00:00

  • Changes in tension of slow motor units in rat medial gastrocnemius during constant-rate stimulation at different frequencies.

    abstract::Changes in tension of slow motor units in the medial gastrocnemius muscle of the rat were measured and compared in three fatigue tests, each of 4 min duration. In one of these tests motor unit tetani were evoked by repeated trains of stimuli of the standard frequency, 40 Hz, while in other tests frequencies of 20 and ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1995.sp003907

    authors: Celichowski J,Grottel K

    更新日期:1995-11-01 00:00:00

  • Metabolic plasticity mediates differential responses to spring and autumn migrations: Evidence from gene expression patterns in migratory buntings.

    abstract:NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087974

    authors: Sharma A,Kumar V

    更新日期:2019-12-01 00:00:00

  • Is rate-pressure product of any use in the isolated rat heart? Assessing cardiac 'effort' and oxygen consumption in the Langendorff-perfused heart.

    abstract:NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP085380

    authors: Aksentijević D,Lewis HR,Shattock MJ

    更新日期:2016-02-01 00:00:00

  • Activation of the 5-HT7 receptor but not nitric oxide synthase is necessary for chronic 5-hydroxytryptamine-induced hypotension.

    abstract:NEW FINDINGS:What is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5-hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5-hydroxytryptamine-induced hypotension requires continued activation of the 5-HT7 rece...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP088919

    authors: Seitz BM,Fink GD,Watts SW

    更新日期:2020-10-14 00:00:00

  • Mechanism of pregnancy-induced attenuation of contraction to phenylephrine in rat aorta.

    abstract::The role of endothelium in the decreased contraction to phenylephrine in aorta of pregnant Wistar rats has been studied. Contractions in response to phenylephrine were significantly decreased in aortic rings from pregnant rats compared to those from non-pregnant rats. Pretreatment of the rings with indomethacin did no...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1993.sp003694

    authors: Aloamaka CP,Ezimokhai M,Cherian T,Morrison J

    更新日期:1993-05-01 00:00:00

  • Water and sodium movements across the ruminal epithelium in fed and food-deprived sheep.

    abstract::Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1990.sp003385

    authors: Holtenius K,Dahlborn K

    更新日期:1990-01-01 00:00:00

  • Characteristics of augmented breaths provoked by almitrine bismesylate in cats.

    abstract::The contribution of almitrine bismesylate to the occurrence and pattern of augmented breaths was studied in fifteen spontaneously breathing, anaesthetized cats. Breathing was via a tracheostomy, while the laryngeal resistance to airflow was measured with the larynx isolated in situ. Almitrine bismesylate at a dose of ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1992.sp003565

    authors: Szereda-Przestaszewska M,Jakus J,Stránsky A,Baráni H

    更新日期:1992-01-01 00:00:00

  • Metabolism of perfused pig intercostal muscles evaluated by 31P-magnetic resonance spectroscopy.

    abstract::This study presents a perfused preparation for evaluation of metabolism in pig intercostal muscle in vitro. Preserved vessels and nerves to an intercostal segment including two adjacent ribs allowed for tissue perfusion and electrical stimulation with measurement of contraction force, oxygen consumption and 31P-magnet...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2006.033274

    authors: Pedersen BL,Arendrup H,Secher NH,Quistorff B

    更新日期:2006-07-01 00:00:00

  • Cardiac parasympathetic outflow during dynamic exercise in humans estimated from power spectral analysis of P-P interval variability.

    abstract:NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP085420

    authors: Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

    更新日期:2016-03-01 00:00:00

  • Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats.

    abstract::What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP085716

    authors: Donnelly WT,Bartlett D Jr,Leiter JC

    更新日期:2016-07-01 00:00:00

  • Double-sigmoid model for fitting fatigue profiles in mouse fast- and slow-twitch muscle.

    abstract::We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2007.041285

    authors: Cairns SP,Robinson DM,Loiselle DS

    更新日期:2008-07-01 00:00:00

  • Electric field-induced orientation of rat hippocampal neurones in vitro.

    abstract::Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1992.sp003580

    authors: Rajnicek AM,Gow NA,McCaig CD

    更新日期:1992-01-01 00:00:00

  • Smoking during pregnancy increases chemerin expression in neonatal tissue.

    abstract:NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087307

    authors: Reynolds LJ,Chavan NR,DeHoff LB,Preston JD,Maddox HF,O'Brien JM,Armstrong DA,Marsit CJ,Pearson KJ

    更新日期:2019-01-01 00:00:00

  • Reduced hypoxic ventilatory response in newborn mice knocked-out for the progesterone receptor.

    abstract::Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclea...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2014.080986

    authors: Potvin C,Rossignol O,Uppari N,Dallongeville A,Bairam A,Joseph V

    更新日期:2014-11-01 00:00:00

  • Analysis and presentation of intracellular measurements obtained with ion-selective microelectrodes.

    abstract::We have considered the manner in which data obtained with ion-selective electrodes should be evaluated. The potential difference recorded by such electrodes, with respect to a stable reference, is converted to a concentration by a non-linear transformation--the Nernst or Nikolsky equation. The mean and standard deviat...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1990.sp003393

    authors: Fry CH,Hall SK,Blatter LA,McGuigan JA

    更新日期:1990-03-01 00:00:00

  • Role of cyclooxygenase in the vascular responses to extremity cooling in Caucasian and African males.

    abstract:NEW FINDINGS:What is the central question of this study? Compared with Caucasians, African individuals are more susceptible to non-freezing cold injury and experience greater cutaneous vasoconstriction and cooler finger skin temperatures upon hand cooling. We investigated whether the enzyme cyclooxygenase is, in part, ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086186

    authors: Maley MJ,House JR,Tipton MJ,Eglin CM

    更新日期:2017-07-01 00:00:00

  • Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats.

    abstract:NEW FINDINGS:What is the central question of this study? In fever, the most striking response in the acute phase reaction of systemic inflammation, plasma H2 S concentration increases. However, the role of endogenous peripheral H2 S in fever is unknown. What is the main finding and its importance? Endogenous peripheral...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086775

    authors: Soriano RN,Braga SP,Breder JSC,Batalhao ME,Oliveira-Pelegrin GR,Ferreira LFR,Rocha MJA,Carnio EC,Branco LGS

    更新日期:2018-03-01 00:00:00

  • Crosstalk between the renal sympathetic nerve and intrarenal angiotensin II modulates proximal tubular sodium reabsorption.

    abstract:NEW FINDINGS:What is the topic of this review? The sympathetic control of renal sodium tubular reabsorption is dependent on activation of the intrarenal renin-angiotensin system and activation of the angiotensin II type 1 (AT1 ) receptor by angiotensin II. What advances does it highlight? Despite the fact that the inte...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP085075

    authors: Pontes RB,Girardi AC,Nishi EE,Campos RR,Bergamaschi CT

    更新日期:2015-04-20 00:00:00

  • Dopamine D1 receptors control exercise hyperpnoea in mice.

    abstract::Previously, we undertook simultaneous recording of ventilation and pulmonary gas exchange in mice and revealed that dopamine D(2) receptors participate in exercise hyperpnoea via behavioural control of ventilation with unchanged pulmonary gas exchange. Here, we examined the hypothesis that D(1) receptors also contribu...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2012.068312

    authors: Iwase M,Izumizaki M,Tsuchiya N,Homma I

    更新日期:2013-02-01 00:00:00

  • Control of breathing and muscle perfusion in humans.

    abstract::Very brief and intense exercise triggers a biphasic metabolic and respiratory response with a second phase that occurs after the cessation of the muscular activity. The effects on minute ventilation (V(E)) produced by manipulation of the peripheral circulation in metabolically active muscles could thus be studied with...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-445x.2001.tb00041.x

    authors: Haouzi P,Chenuel B,Chalon B

    更新日期:2001-11-01 00:00:00

  • Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies.

    abstract::Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2013.075408

    authors: Piskuric NA,Zhang M,Vollmer C,Nurse CA

    更新日期:2014-01-01 00:00:00

  • The splanchnic anti-inflammatory pathway: could it be the efferent arm of the inflammatory reflex?

    abstract::What is the topic of this review? We review the current literature on the neural reflex termed the 'inflammatory reflex' that inhibits an excessive release of inflammatory mediators in response to an immune challenge. What advances does it highlight? The original model proposed that the inflammatory reflex is a vago-v...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP085559

    authors: Martelli D,Farmer DG,Yao ST

    更新日期:2016-10-01 00:00:00

  • Activation of cellular apoptosis in the caecal epithelium is associated with increased oxidative reactions in lactating goats after feeding a high-concentrate diet.

    abstract:NEW FINDINGS:What is the central question of this study? What are the ultrastructural changes of the caecal mucosa and the status of epithelial cellular apoptosis and oxidative reactions in lactating goats after prolonged feeding with a high-concentrate diet? What is the main finding and its importance? High-concentrat...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2014.083352

    authors: Tao S,Tian J,Cong R,Sun L,Duanmu Y,Dong H,Ni Y,Zhao R

    更新日期:2015-03-01 00:00:00

  • Increased sensitization of the myofilaments in rat neonatal portal vein: a potential mechanism.

    abstract::The contractile regulation of neonatal smooth muscle was studied in rat neonatal portal vein. Strips of beta-escin-permeabilized portal vein from 3- to 5-day-old rats and 5- to 6-week-old rats were mounted on a 'bubble chamber' in calcium solutions buffered with 10 mM EGTA. Although the overall tension development was...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1997.sp004084

    authors: Bruce L,Nixon GF

    更新日期:1997-11-01 00:00:00

  • Effects of sex and ovarian hormones on the initial renal sympathetic nerve activity response to myocardial infarction.

    abstract::The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA responses to MI. In anaesthetized, open-chest male, female an...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2012.065615

    authors: Pinkham MI,Guild SJ,Malpas SC,Barrett CJ

    更新日期:2012-09-01 00:00:00

  • Reflex respiratory responses to continuous and intermittent stimulation of afferent fibres from muscles in cats.

    abstract::In anaesthetized cats, reflex respiratory responses were evoked by electrically stimulating proximal ends of cut nerves to gastrocnemius-soleus muscles of the left hindlimb. The direction of these responses, in the excitatory or inhibitory sense, depended on the types of afferent fibres stimulated and on the mode of s...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1995.sp003826

    authors: Decandia M,Orani GP

    更新日期:1995-01-01 00:00:00

  • Changes in prefrontal cerebral oxygenation and microvascular blood volume in hypoxia and possible association with acute mountain sickness.

    abstract:NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP088515

    authors: Manferdelli G,Marzorati M,Easton C,Porcelli S

    更新日期:2021-01-01 00:00:00