The role of gut endocrine cells in control of metabolism and appetite.

Abstract:

:After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is considered partly responsible for the normalization of glycaemic control and the reduction in appetite seen in many patients after certain forms of bariatric surgery. This review describes recent developments in our understanding of the secretion and action of anorexigenic gut hormones, primarily concentrating on glucagon-like peptide-1 (GLP-1).

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Parker HE,Gribble FM,Reimann F

doi

10.1113/expphysiol.2014.079764

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1116-20

issue

9

eissn

0958-0670

issn

1469-445X

pii

99/9/1116

journal_volume

99

pub_type

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