T cell derived cytokines in lung-phase immunity to Schistosoma mansoni.

Abstract:

:In C57Bl/6 strain mice vaccinated with radiation-attenuated cercariae of Schistosoma mansoni immune elimination of challenge parasites occurs in the lungs. Leucocytes were recovered from the lungs of such mice by bronchoalveolar lavage and cultured in vitro with larval antigen; the profile of cytokines released was then analyzed. From 14 days after vaccination, BAL cultures contained infiltrating lymphocytes which produced abundant quantities of IFN-g and IL-3. Challenge of vaccinated mice resulted in a second influx of IFN-g and IL-3--producing cells, earlier than after vaccination or in the appropriate controls. Ablation studies revealed that CD4+ T cells were the source of IFN-g. The timing of cytokine production after vaccination, and challenge was coincident with the phases of macrophage activation previously reported. At no time could lymphocytes in BAL cultures be stimulated to proliferate with either larval Ag or mitogen, in contrast to splenocytes from the same mice. Furthermore, T cell growth factor activity was not detected in BAL cultures stimulated with Ag. We suggest that the lymphocytes recruited to the lungs are memory/effector cells. When Ag released from challenge schistosomula is presented to these cells, they respond by secreting cytokines which mediate the formation of cellular aggregates around the parasites, blocking their onward migration.

journal_name

Mem Inst Oswaldo Cruz

authors

Wilson RA

doi

10.1590/s0074-02761992000800015

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

105-9

eissn

0074-0276

issn

1678-8060

pii

S0074-02761992000800015

journal_volume

87 Suppl 4

pub_type

杂志文章,评审
  • Successes and failures of sixty years of vector control in French Guiana: what is the next step?

    abstract::Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniq...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/0074-02760170398

    authors: Epelboin Y,Chaney SC,Guidez A,Habchi-Hanriot N,Talaga S,Wang L,Dusfour I

    更新日期:2018-03-12 00:00:00

  • First isolation of West Nile virus in Brazil.

    abstract:BACKGROUND:Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES:We sought to identify the viral etiology of equine encephalitis in Espírito Santo state. METHODS:We performed...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760180332

    authors: Martins LC,Silva EVPD,Casseb LMN,Silva SPD,Cruz ACR,Pantoja JAS,Medeiros DBA,Martins Filho AJ,Cruz EDRMD,Araújo MTF,Cardoso JF,Cunha MACRD,Almada GL,Romano APM,Santos MGDP,Rodrigues GAP,Chiang JO,Quaresma JAS,Carvalho

    更新日期:2019-01-17 00:00:00

  • The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis.

    abstract::Trypanosomes are parasitic protozoa in which gene expression is primarily controlled through the regulation of mRNA stability and translation. This post-transcriptional control is mediated by various families of RNA-binding proteins, including those with zinc finger CCCH motifs. CCCH zinc finger proteins have been sho...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762012000600014

    authors: Mörking PA,Rampazzo Rde C,Walrad P,Probst CM,Soares MJ,Gradia DF,Pavoni DP,Krieger MA,Matthews K,Goldenberg S,Fragoso SP,Dallagiovanna B

    更新日期:2012-09-01 00:00:00

  • Molecular epidemiology of Hepatitis delta virus infection in Minas Gerais state from Brazil, an area outside the hyperendemic region of the Amazon Basin.

    abstract:BACKGROUND:Hepatitis delta virus (HDV) infections in hepatitis B virus (HBV) carriers are the most severe form of viral hepatitis. HDV prevalence is high in the Brazilian Amazon, but studies in other regions of the country are still scarce and often underestimated its prevalence by including a small numbers of individu...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760190074

    authors: Scarponi CF,Kroon EG,Vieira DS,Fernandes AP,Gomes KB,Mota BE

    更新日期:2019-01-01 00:00:00

  • A comparative evaluation of end-emic and non-endemic region of visceral leishmaniasis (Kala-azar) in India with ground survey and space technology.

    abstract::In visceral leishmaniasis, phlebotomine vectors are targets for control measures. Understanding the ecosystem of the vectors is a prerequisite for creating these control measures. This study endeavours to delineate the suitable locations of Phlebotomus argentipes with relation to environmental characteristics between ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000500001

    authors: Kesari S,Bhunia GS,Kumar V,Jeyaram A,Ranjan A,Das P

    更新日期:2011-08-01 00:00:00

  • Increasing the digital repository of DNA barcoding sequences of sand flies (Psychodidae: Phlebotominae).

    abstract::Sand fly identification is complex because it depends on the expertise of the taxonomist. The females show subtle morphological differences and the occurrence of the species complexes are usual in this taxon. Therefore, a fragment of the cytochrome c oxidase subunit I (COI) gene is used for taxon barcoding to resolve ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760190208

    authors: Laurito M,Ontivero IM,Almirón WR

    更新日期:2019-11-28 00:00:00

  • Molecular characterisation of Sporothrix schenckii isolates from humans and cats involved in the sporotrichosis epidemic in Rio de Janeiro, Brazil.

    abstract::An epidemic of sporotrichosis, a subcutaneous mycosis caused by the fungus Sporothrix schenckii, is ongoing in Rio de Janeiro, Brazil, in which cases of human infection are related to exposure to cats. In an attempt to demonstrate the zoonotic character of this epidemic using molecular methodology, we characterised by...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000500018

    authors: Reis RS,Almeida-Paes R,Muniz Mde M,Tavares PM,Monteiro PC,Schubach TM,Gutierrez-Galhardo MC,Zancopé-Oliveira RM

    更新日期:2009-08-01 00:00:00

  • Gastropods as intermediate hosts of Angiostrongylus spp. in the Americas: bioecological characteristics and geographical distribution.

    abstract:BACKGROUND:Intermediate hosts are key organisms in maintaining parasite life cycles, because they can act as amplifiers in the transmission from natural reservoirs to humans. One of the most important groups of intermediate hosts for zoonotic nematode infections are gastropods,slugs and snails. These are essential orga...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/0074-02760200236

    authors: Valente R,Robles MDR,Diaz JI

    更新日期:2020-11-27 00:00:00

  • Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects.

    abstract::BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760180328

    authors: Lima LRP,Araújo NA,Guterres A,Pilotto JH,Niel C,Paula VS

    更新日期:2018-12-03 00:00:00

  • Leprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countries.

    abstract::Leprosy is an ancient disease that remains endemic and continues to be a major public health problem in some tropical countries, where it has been internationally recognized as being linked to the underdevelopment conditions. The natural course of the disease covers a wide variety of clinical conditions with systemic ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762012000900006

    authors: Foss NT,Motta AC

    更新日期:2012-12-01 00:00:00

  • In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis.

    abstract::Mutations in the katG gene have been identified and correlated with isoniazid (INH) resistance in Mycobacterium tuberculosis isolates. The mutation AGC-->ACC (Ser-->Thr) at katG315 has been reported to be the most frequent and is associated with transmission and multidrug resistance. Rapid detection of this mutation c...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000500008

    authors: Verza M,Maschmann Rde A,Silva MS,Dalla Costa ER,Ribeiro MO,Rosso F,Suffys PN,Tortoli E,Marcelli F,Zaha A,Rossetti ML

    更新日期:2009-08-01 00:00:00

  • Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food.

    abstract::Toxicological and toxicogenetic effects of aqueous (tea) and hexanic fruit extract of Indigofera suffruticosa Mill. and hydroalcoholic root extract of Solanum agrarium Stendt. were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit ext...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761991000600022

    authors: Ribeiro LR,Bautista AR,Silva AR,Sales LA,Salvadori DM,Maia PC

    更新日期:1991-01-01 00:00:00

  • Comparative analysis by polymerase chain reaction amplified minicircles of kinetoplast DNA of a stable strain of Trypanosoma cruzi from São Felipe, Bahia, its clones and subclones: possibility of predominance of a principal clone in this area.

    abstract::Molecular characterization of one stable strain of Trypanosoma cruzi, the 21 SF, representative of the pattern of strains isolated from the endemic area of São Felipe, State of Bahia, Brazil, maintained for 15 years in laboratory by serial passages in mice and classified as biodeme Type II and zymodeme 2 has been inve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000100009

    authors: Campos RF,Gonçalves MS,dos Reis EA,dos Reis MG,Andrade SG

    更新日期:1999-01-01 00:00:00

  • Polymorphism in trypomastigotes of Trypanosoma (Megatrypanum) minasense in the blood of experimentally infected squirrel monkey and marmosets.

    abstract::Experimental infections by Trypanosoma (Megatrypanum) minasense were performed in primates - Saimiri sciureus and Callithrix penicillata - with the objective of searching for morphological variations of the blood trypomastigotes with respect to hosts and time of infection. We carried out morphological and morphometric...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000500016

    authors: Ziccardi M,Lourenco-de-Oliveira R

    更新日期:1999-09-01 00:00:00

  • Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients.

    abstract::The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemical parameters as di...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000300011

    authors: Hamed MA,Ahmed SA,Khaled HM

    更新日期:2011-05-01 00:00:00

  • Ecological analysis of acari recovered from coprolites from archaeological site of northeast Brazil.

    abstract::Coprolite samples of human and animal origin from the excavations performed at the archaeological site of Furna do Estrago, at Brejo da Madre de Deus in the state of Pernambuco, Brazil and sent to the Paleoparasitology Laboratory at Escola Nacional de Saúde Pública-Fiocruz, Rio de Janeiro, were analyzed for mites. Aft...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762003000900027

    authors: de Candanedo Guerra Rde M,Gazêta GS,Amorim M,Duarte AN,Serra-Freire NM

    更新日期:2003-01-01 00:00:00

  • Pathology and first occurrence of the kidney trematode Paratanaisia bragai (Santos, 1934) Freitas, 1959 (Digenea: Eucotylidae) in Phasianus colchicus L., 1758, from Brazil.

    abstract::The kidney trematode Paratanaisia bragai is reported for the first time parasitizing the ring-necked pheasant (Phasianus colchicus L., 1758) and the pathological alterations associated to the parasitism are referred on the basis of 50 specimens of this bird from backyard flocks in 11 counties of the state of Rio de Ja...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762005000300013

    authors: Gomes DC,Menezes RC,Tortelly R,Pinto RM

    更新日期:2005-05-01 00:00:00

  • Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil.

    abstract::We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 var...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000300007

    authors: Cruz MR,Cerqueira DM,Cruz WB,Camara GN,Brígido MM,Silva EO,Carvalho LG,Martins CR

    更新日期:2004-05-01 00:00:00

  • Evolutionary histories of expanded peptidase families in Schistosoma mansoni.

    abstract::Schistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main virulence factors involved in the pathogenesis of this disease. In this ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000700013

    authors: Silva LL,Marcet-Houben M,Zerlotini A,Gabaldón T,Oliveira G,Nahum LA

    更新日期:2011-11-01 00:00:00

  • Human toxocariasis: a seroepidemiological survey in schoolchildren of Sorocaba, Brazil.

    abstract::A seroepidemiological survey for toxocariasis, among 180 schoolchildren of the public schools of Sorocaba City, state of São Paulo, Brazil, was carried out from August 2000 to July 2001. ELISA test was performed using excretory and secretory antigens for the detection of IgG anti-Toxocara antibodies. Information regar...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:/S0074-02762004000600002

    authors: Coelho LM,Silva MV,Dini CY,Giacon Neto AA,Novo NF,Silveira EP

    更新日期:2004-10-01 00:00:00

  • BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis--review.

    abstract::The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 历史文章,杂志文章,评审

    doi:10.1590/s0074-02762005000500002

    authors: Benévolo-de-Andrade TC,Monteiro-Maia R,Cosgrove C,Castello-Branco LR

    更新日期:2005-08-01 00:00:00

  • Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum.

    abstract::BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760180279

    authors: Penna-Coutinho J,Aguiar AC,Krettli\/ AU

    更新日期:2018-12-06 00:00:00

  • Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil.

    abstract:BACKGROUND:Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760190004

    authors: Ornelas AMM,Xavier-de-Carvalho C,Alvarado-Arnez LE,Ribeiro-Alves M,Rossi ÁD,Tanuri A,de Aguiar RS,Moraes MO,Cardoso CC

    更新日期:2019-01-01 00:00:00

  • Human eosinophil-lymphocyte interactions.

    abstract::While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocyte is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense, Eosinophils a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761997000800023

    authors: Weller PF,Lim K

    更新日期:1997-01-01 00:00:00

  • Localization of Brugia malayi (sub-periodic) adults in different organs of Mastomys coucha and its influence on microfilaraemia and host antibody response.

    abstract::Lymphatic filariasis caused by nematode parasites Wuchereria bancrofti or Brugia malayi is a spectral disease and produces wide range of immune responses and varying levels of microfilaraemia in infected individuals. The relationship between the immune response of host and the developmental stage of the parasite as we...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000300007

    authors: Athisaya Mary K,Hoti S,Paily K

    更新日期:2006-05-01 00:00:00

  • Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses.

    abstract:BACKGROUND:Dengue virus (DENV) has circulated in Brazil for over 30 years. During this time, one serotype has cyclically replaced the other, until recently, when all four distinct serotypes began to circulate together. Persistent circulation of DENV for long time periods makes sequential infections throughout a person'...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760190098

    authors: Oliveira RA,de Oliveira-Filho EF,Fernandes AI,Brito CA,Marques ET,Tenório MC,Gil LH

    更新日期:2019-01-01 00:00:00

  • Faecal examination and PCR to detect Strongyloides venezuelensis in experimentally infected Lewis rats.

    abstract::More sensitive methodologies are necessary to improve strongyloidiasis diagnosis. This study compared the sensitivities of the McMaster modified technique and polymerase chain reaction (PCR) assays, both performed in faecal samples. Lewis rats were subcutaneously infected with 4,000, 400 or 40 infective third-stage la...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762010000100008

    authors: Marra NM,Chiuso-Minicucci F,Machado GC,Zorzella-Pezavento SF,França TG,Ishikawa LL,Amarante AF,Sartori A,Amarante MR

    更新日期:2010-02-01 00:00:00

  • Toxoplasma gondii infection induces lipid metabolism alterations in the murine host.

    abstract::Host lipids have been implicated in the pathogenesis of Toxoplasma gondii infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zer...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000200008

    authors: Milovanović I,Vujanić M,Klun I,Bobić B,Nikolić A,Ivović V,Trbovich AM,Djurković-Djaković O

    更新日期:2009-03-01 00:00:00

  • Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae.

    abstract::A ribosome association factor (AF) was isolated from the yeast Sacchharomyces cerevisiae. Partial amino acid sequence of AF was determined from its fragment of 25 kDa isolated by treating AF with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-Bromoindolenine (BNPS-skatole). This sequence has a 86% identity to the product of th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000700012

    authors: Correia H,Medina R,Hernández A,Bustamante E,Chakraburtty K,Herrera F

    更新日期:2004-11-01 00:00:00

  • Appraisal of Phlebotomus argentipes habitat suitability using a remotely sensed index in the kala-azar endemic focus of Bihar, India.

    abstract::Visceral leishmaniasis, or kala-azar, is recognised as a serious emerging public health problem in India. In this study, environmental parameters, such as land surface temperature (LST) and renormalised difference vegetation indices (RDVI), were used to delineate the association between environmental variables and Phl...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276108022013012

    authors: Kesari S,Bhunia GS,Chatterjee N,Kumar V,Mandal R,Das P

    更新日期:2013-04-01 00:00:00