Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food.

Abstract:

:Toxicological and toxicogenetic effects of aqueous (tea) and hexanic fruit extract of Indigofera suffruticosa Mill. and hydroalcoholic root extract of Solanum agrarium Stendt. were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group treated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LD50) of hydroalcoholic root extract of S. agrarium. The results obtained show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.

journal_name

Mem Inst Oswaldo Cruz

authors

Ribeiro LR,Bautista AR,Silva AR,Sales LA,Salvadori DM,Maia PC

doi

10.1590/s0074-02761991000600022

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

89-91

eissn

0074-0276

issn

1678-8060

pii

S0074-02761991000600022

journal_volume

86 Suppl 2

pub_type

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