BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis--review.


:The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seventies when it was replaced by the intradermal route. This change in route of delivery was mainly secondary to pressure by medical practitioners based on the poor responses of oral immunized subjects to purified protein derivative (PPD) skin tests. Even after the change of route of delivery, Ataulpho de Paiva Foundation continued making the oral vaccine. Currently, BCG Moreau has been described as one of the most immunogenic and with fewer side effects than other BCGs. The genomics, proteomics and vaccine trials for oral BCG Moreau Rio de Janeiro are currently under investigation. In this review, we intend to describe the history of BCG Moreau Rio de Janeiro in Brazil.


Mem Inst Oswaldo Cruz


Benévolo-de-Andrade TC,Monteiro-Maia R,Cosgrove C,Castello-Branco LR




Has Abstract


2005-08-01 00:00:00














  • Partial molecular characterization of Sm8, a tegumental antigen of Schistosoma mansoni.

    abstract::Sm8 is a major tegumental antigen of Schistosoma mansoni. The partial cDNA was isolated and analyzed. Sequence analysis revealed transmembrane compatible hydrophobic domains and a putative leucine zipper pattern. The mRNA and the protein are predominantly expressed in adult worms. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Abath FG,Xavier EM,Montenegro SM,Werkhauser RP

    更新日期:2002-01-01 00:00:00

  • Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana.

    abstract:BACKGROUND:In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES:In order to improve vector control it is essentia...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Salgueiro P,Restrepo-Zabaleta J,Costa M,Galardo AKR,Pinto J,Gaborit P,Guidez A,Martins AJ,Dusfour I

    更新日期:2019-09-23 00:00:00

  • [Fecal coliforms in sewage waters. I. Resistance to antibiotics, heavy metals and colicinogeny].

    abstract::Qualitative bacteriological analysis was carried out in two sewage treatment plants in the city of Rio de Janeiro during the period 1984-1985. Specific points of the plants were selected for the collection of affluent and effluent samples. The study involved the isolation and the identification of 540 cultures of Esch...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ribeiro Dias JC,Vicente AC,Hofer E

    更新日期:1987-07-01 00:00:00

  • Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection.

    abstract::Direct smear examination using Ziehl-Neelsen staining for pulmonary tuberculosis (PTB) diagnosis is inexpensive and easy to use, but has the major limitation of low sensitivity. Rapid molecular methods are becoming more widely available in centralized laboratories, but they depend on timely reporting of results and st...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Michelon CT,Rosso F,Schmid KB,Sperhacke RD,Oliveira MM,Kritski AL,Rezende L Jr,Costa ER,Ribeiro AW,Verza M,Cafrune PI,Silva MS,Kuhleis D,Zaha A,Rossetti ML

    更新日期:2011-03-01 00:00:00

  • Nested PCR to detect and distinguish the sympatric filarial species Onchocerca volvulus, Mansonella ozzardi and Mansonella perstans in the Amazon Region.

    abstract::We present filaria-nested polymerase chain reaction (PCR), which is based on amplification of first internal transcribed spacer rDNA to distinguish three parasitic filarial species (Onchocerca volvulus, Mansonella ozzardi and Mansonella perstans) that can be found in the Amazon Region. Nested PCR-based identifications...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Tang TH,López-Vélez R,Lanza M,Shelley AJ,Rubio JM,Luz SL

    更新日期:2010-09-01 00:00:00

  • Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C mice.

    abstract::Angiotensin II (AII), a product of rennin-angiotensin system, exerts an important role on the function of immune system cells. In this study, the effect of AII on the phagocytic activity of mouse peritoneal macrophages was assessed. Mice peritoneal macrophages were cultured for 48 h and the influence of different conc...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Belline P,da Melo PS,Haun M,Palhares FB,Boer PA,Gontijo JA,Figueiredo JF

    更新日期:2004-03-01 00:00:00

  • Assessment of immunological changes in Epstein-Barr virus co-infection in Egyptian chronic HCV patients.

    abstract::Epstein-Barr virus (EBV) plays a major role in liver pathology. Similar to other members of the herpesvirus family, EBV establishes a persistent infection in more than 90% of adults. The aim of this study was to evaluate the impact of EBV and chronic hepatitis C co-infection (HCV) on biochemical and immunological resp...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Shoman S,Nabil M,Tabl A,Ghanem H,Kafrawy SE

    更新日期:2014-09-01 00:00:00

  • Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children.

    abstract::The aim of the present study was to identify specific markers that mirror liver fibrosis progression as an alternative to biopsy when biopsy is contraindicated, especially in children. After liver biopsies were performed, serum samples from 30 hepatitis C virus (HCV) paediatric patients (8-14 years) were analysed and ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Nassef YE,Shady MM,Galal EM,Hamed MA

    更新日期:2013-11-01 00:00:00

  • Prevalence and control of babesiosis in the Americas.

    abstract::This review presents up-to-date information on the distribution and control measures of babesiosis in Latin America. Bovine babesiosis caused by Babesia bovis and B. bigemia will be emphasized. The disease is endemic in most countries and poses a serious economic burden on livestock production in the region (U.S. $136...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Montenegro-James S

    更新日期:1992-01-01 00:00:00

  • Sandfly species diversity in association with human activities in the Kani tribe settlements of the Western Ghats, Thiruvananthapuram, Kerala, India.

    abstract::Sandfly prevalence in the Kani tribe settlements of Western Ghats in India was investigated. A total of 1,279 sandflies comprising 17 species was obtained. Sandfly abundance showed a negative correlation (r = -0.97, p = 0.003) with increase in altitudinal ranges from 0-1,000 m. When sandfly samples were grouped accord...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ranganathan S,Swaminathan S

    更新日期:2015-04-01 00:00:00

  • alpha-glycerophosphate dehydrogenase activity in flight muscles of triatomine bugs Panstrongylus megistus and Triatoma sordida.

    abstract::The alpha-glycerophosphate dehydrogenase (alpha-GPDH) activity in flight muscles of Panstrongylus megistus and Triatoma sordida, vectors of Chagas disease in Brazil, was studied. Both species showed higher enzymatic activities in fliers than in non-fliers insects. T. sordida exhibited a higher proportion of flier inse...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Soares RP,Santoro MM

    更新日期:2000-09-01 00:00:00

  • Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart.

    abstract::Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a l...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Paranhos-Silva M,Pontes-de-Carvalho LC,de Sá Oliveira GG,Nascimento EG,dos-Santos WL

    更新日期:2001-07-01 00:00:00

  • Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease.

    abstract:BACKGROUND:Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects i...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Irion CI,Paredes BD,Brasil GV,Cunha STD,Paula LF,Carvalho AR,Carvalho ACC,Carvalho AB,Goldenberg RCDS

    更新日期:2017-08-01 00:00:00

  • Experimental Chagas' disease in rhesus monkeys. I. Clinical, parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the disease.

    abstract::Rhesus monkeys (Macaca mulatta) were infected subcutaneously with 1.0 x 10(4) to 1.5 x 10(4) metacyclic trypomastigotes of Trypanosoma cruzi (Colombian strain). Parasitological and immunological parameters were evaluated in these animals for periods of 1 month to over 3 years. A chagoma was observed between the 3rd an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Bonecini-Almeida Mda G,Galvão-Castro B,Pessoa MH,Pirmez C,Laranja F

    更新日期:1990-04-01 00:00:00

  • Application of WHO International Biological Reference Standards to evaluate commercial serological tests for chronic Chagas disease.

    abstract::BACKGROUND Chagas disease, resulting from Trypanosoma cruzi infections, continues to be a health concern mainly in Latin American countries where the parasite is endemic. The laboratory diagnosis of a chronic infection is determined through serological assays for antibodies against T. cruzi and several tests are avail...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Sáez-Alquezar A,Junqueira ACV,Durans ADM,Guimarães AV,Corrêa JA,Provance DW Jr,Cabello PH,Coura JR,Viñas PA

    更新日期:2020-01-01 00:00:00

  • Redescription of Anopheles (Nyssorhynchus) antunesi Galvão & Amaral and description of a new species of the Myzorhynchella Section (Diptera: Culicidae) from Serra da Mantiqueira, Brazil.

    abstract::Anopheles (Nyssorhynchus) pristinus Nagaki & Sallum, n. sp. of the Myzorhynchella Section is described based on morphological characters of adult females, males, fourth-instar larvae, pupae and male genitalia. Anopheles (Nyssorhynchus) antunesi Galvão & Amaral is characterized to fix its identity and distinguish it fr...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Nagaki SS,Motta Mde A,Sallum MA

    更新日期:2010-05-01 00:00:00

  • [Complement fixation reaction in the typing of influenza viruses isolated in Rio de Janeiro].

    abstract::The author studied by the complement fixation test the influenza virus strains isolated in Rio de Janeiro during the 1973 epidemic. He prepared immunesera in hamsters by the inoculation of the allantoic fluid from infected chick embryos with each of the 7 isolated strains and the standard strains. The soluble antigens...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Lacorte JG

    更新日期:1976-01-01 00:00:00

  • Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients.

    abstract::The schistosomal parasite plays a critical role in the development of malignant lesions in different organs. The pathogenesis of cancer is currently under intense investigation to identify reliable prognostic indices for disease detection. The objective of this paper is to evaluate certain biochemical parameters as di...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Hamed MA,Ahmed SA,Khaled HM

    更新日期:2011-05-01 00:00:00

  • Age structure and abundance in populations of muscoid flies from a poultry facility in Southeast Brazil.

    abstract::Muscina stabulans, M. domestica, Chrysomya putoria, C. megacephala and Stomoxys calcitrans were the most abundant muscoid flies captured in a poultry facility in southeastern Brazil. We examined the gonadotrophic profiles of the females caught at different sites and different times and found that Mu. stabulans and M. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Avancini RM,Silveira GA

    更新日期:2000-03-01 00:00:00

  • Description of Lutzomyia (Lutzomyia) falquetoi sp. nov. (Diptera: Psychodidae, Phlebotominae) a new species from the state of Espírito Santo, Brazil.

    abstract::Lutzomyia (Lutzomyia) falquetoi, sp. nov. (Diptera: Psychodidae, Phlebotominae) is described from the state of Espírito Santo, Brazil. This new species belongs to the series longipalpis and is easily distinguished from the other members of this taxon by the presence of five well-developed spines and a pre-apical spini...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Pinto Ide S,Dos Santos CB

    更新日期:2007-05-01 00:00:00

  • Reinfection in American cutaneous leishmaniasis: evaluation of clinical outcomes in the hamster model.

    abstract::There is no clear understanding of the outcome of reinfection in New World cutaneous leishmaniasis, and its role in the relationship to the development of protection or secondary disease. For this reason, reinfection experiments with homologous (Leishmania panamensis-L. panamensis) and heterologous (L. major-L. paname...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Osorio Y,Gonzalez SJ,Gama VL,Travi BL

    更新日期:1998-05-01 00:00:00

  • Diagnostic challenges of single plaque-like lesion paucibacillary leprosy.

    abstract::The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Barbieri RR,Sales AM,Illarramendi X,Moraes MO,Nery JA,Moreira SJ,Sarno EN,Machado Ade M,Bozza FA

    更新日期:2014-11-01 00:00:00

  • Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium.

    abstract::An overview is presented of the results obtained with biodegradable sustained release devices (SRDs) containing a mixture of polymers and either isometamidium (ISMM) or ethidium. Under controlled laboratory conditions (monthly challenge with tsetse flies infected with Trypanosoma congolense) the protection period in S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,评审


    authors: Geerts S,Brandt J,De Deken R

    更新日期:1999-03-01 00:00:00

  • Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals.

    abstract::Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Basombrío MA,Segura MA,Gómez L,Padilla M

    更新日期:2000-01-01 00:00:00

  • Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century.

    abstract::In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas disease. More than two thousand children under the age of 14 have be...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Villa L,Morote S,Bernal O,Bulla D,Albajar-Vinas P

    更新日期:2007-10-30 00:00:00

  • Benzonidazole levels in blood vary with age in rats.

    abstract::Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the prese...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Bulffer RF,Castro JA,Fanelli SL

    更新日期:2011-05-01 00:00:00

  • Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina.

    abstract::St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) present ecological and antigenic similarities and are responsible for serious human diseases. In addition, WNV is a significant pathogen in terms of equine health. The purpose of our study was to analyse the seroprevalence of SLEV and WNV in equine sera col...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Tauro L,Marino B,Diaz LA,Lucca E,Gallozo D,Spinsanti L,Contigiani M

    更新日期:2012-06-01 00:00:00

  • Sexing sand fly pupae (Diptera: psychodidade: phlebotominae).

    abstract::We describe a technique to separate male and female pupae of sand flies. This has reduced the labour to separate flies after emergence and also allows the isolation of unmated adults for behavioural and physiological studies. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Brazil BG,Brazil RP

    更新日期:2000-07-01 00:00:00

  • A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence.

    abstract::Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocy...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Kemp DJ,Thompson J,Barnes DA,Triglia T,Karamalis F,Petersen C,Brown GV,Day KP

    更新日期:1992-01-01 00:00:00

  • Antibacterial activity of extracts and neolignans from Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck.

    abstract::The evaluation of the activity of the aqueous and ethyl acetate extracts of the leaves of Piper regnellii was tested against gram-positive and gram-negative bacteria. The aqueous extract displayed a weak activity against Staphylococcus aureus and Bacillus subtilis with minimal inhibitory concentration (MIC) and minima...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Pessini GL,Dias Filho BP,Nakamura CV,Cortez DA

    更新日期:2003-12-01 00:00:00