Vasoactive intestinal peptide enhances thyroidal iodide uptake during dietary iodine deficiency.

abstract：:Combined partial deficiency of 17alpha-hydroxylase and 21-hydroxylase activities was first described in 1985; however the genes for P450c17 and P450c21 in these patients lack mutations. In 1986 we postulated that this disorder might be due to mutations in P450 oxidoreductase (POR), the flavoprotein that donates electr...

journal_title：Endocrine research

authors： Pandey AV,Flück CE,Huang N,Tajima T,Fujieda K,Miller WL

更新日期：2004-11-01 00:00:00

abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...

journal_title：Endocrine research

authors： Wynn J,Shah U,Murray SA

更新日期：2002-11-01 00:00:00

abstract：:The CYP11B2 gene encodes aldosterone synthase, a cytochrome P450 (P450aldo) expressed in high levels in the adrenal zona glomerulosa. While the primary physiologic regulators of aldosterone production are circulating angiotensin II (Ang II) and potassium (K+) the action of these agents on CYP11B2 gene transcription ha...

journal_title：Endocrine research

authors： Clyne CD,White PC,Rainey WE

更新日期：1996-11-01 00:00:00

abstract：:Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...

journal_title：Endocrine research

authors： Arlt W,Callies F,Allolio B

更新日期：2000-11-01 00:00:00

abstract：:The zonal distribution of aldosterone synthase cytochrome P450 (P450aldo) in the adrenal cortex of male hamsters was investigated by immunofluorescence and electron microscopy, using an anti-P450aldo peptide antibody. On cryostat sections the immunolocalization of P450aldo was confined to the zona glomerulosa cells. O...

journal_title：Endocrine research

authors： LeHoux JG,Martel D,LeHoux J,Ducharme L,Lefebvre A,Brière N

更新日期：1995-02-01 00:00:00

abstract：:A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea ...

journal_title：Endocrine research

authors： Bani Hani I,El-Migdadi F,Shotar A,Abudheese R,Bashir N

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether 25-hydroxyvitamin D [25(OH)D] can mediate effects without being converted to 1α,25-dihydroxyvitamin D [1,25(OH)2D]. METHODS:Vitamin D3 (VD3) was injected intramuscularly to 25-hydroxyvitamin D-1α-hydroxylase [1α(OH)ase] gene knockout (KO) male mice with a dose of 10,000 IU per week for...

journal_title：Endocrine research

authors： Zhang ZL,Ding XF,Tong J,Li BY

更新日期：2011-01-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a ...

journal_title：Endocrine research

authors： Shimojo M,Condon J,Whorwood CB,Stewart PM

更新日期：1996-11-01 00:00:00

abstract：:It was the aim of this study to test for a possible effect of the new non ergot dopamine agonist CV 205-502 on plasma growth hormone (GH) concentrations in acromegaly. 10 acromegalic patients received a single oral dose of 150 micrograms CV 205-502 after an overnight fast. As a control group 7 acromegalic patients und...

journal_title：Endocrine research

authors： Svoboda T,Kotzmann H,Clodi M,Bernecker P,Geyer G,Luger A

更新日期：1994-02-01 00:00:00

abstract：:Two distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) with respect to enzymatic activity were identified in the ovine liver and kidney. 11 beta-HSD1 (the hepatic isoform) was reversible and NADP(H)-dependent. By contrast, 11 beta-HSD2 (the renal isoform) was unidirectional and NAD-dependent. Ovin...

journal_title：Endocrine research

authors： Yang K

更新日期：1995-02-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：:The mechanisms by which SF-1 (Steroidogenic Factor-1) and Dax-1 (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome) dictate adrenal-specific transcriptional programs are the focus of this laboratory. SF-1-mediated transcription is upregulated by phosphorylation of serine 20...

journal_title：Endocrine research

authors： Babu PS,Bavers DL,Shah S,Hammer GD

更新日期：2000-11-01 00:00:00

abstract：:The question of whether ethanol's (ETOH's) known suppressive effect on serum luteinizing hormone (LH) could be mediated directly at the anterior pituitary level was addressed by examining the effects of ETOH in vitro on release of LH from cultured male rat pituitary cells. The impact of added ethanol concentrations ra...

journal_title：Endocrine research

authors： Emanuele MA,Tentler J,Emanuele NV,Reda D,Kirsteins L,Lawrence AM

更新日期：1989-01-01 00:00:00

abstract：:The effect of clomiphene on nuclear estrogen receptors of the Fallopian tube during ovum transport in the rabbit has been studied. Nuclear binding capacity was observed in ampulla (A), ampullary-isthmic junction (AIJ), isthmus (I), uterine-isthmic junction (UIJ) and uterus (U). Receptor concentration decreased in all ...

journal_title：Endocrine research

authors： Gupta JS,Roy SK

更新日期：1989-01-01 00:00:00

abstract：:A 30-residue peptide corresponding to the amino acid sequence of steroidogenesis activator peptide (SAP) from rat Leydig tumor cells has been synthesized by the solid-phase method using Boc protection. SAP is the putative cycloheximide-sensitive, cAMP-regulated mediator of ACTH-stimulated conversion of cholesterol to ...

journal_title：Endocrine research

authors： Glass DB,Robertson DG,Xu TS,Bowman EP,Lambeth JD

更新日期：1991-01-01 00:00:00

abstract：:In the guinea pig adrenal the cells of the outer zone secrete high levels of steroid and respond to ACTH with increased synthesis of cholesterol and steroid. The outer zone consists of two cell types: zona fasciculata (ZF) and zona glomerulosa (ZG). To determine the relative contribution of ZF and ZG to the outer zone...

journal_title：Endocrine research

authors： Brody RI,Black VH

更新日期：1991-01-01 00:00:00

abstract：:The recent cloning of a family of melanocortin receptors (MC-R) has identified five distinct G protein- and adenylate cyclase-coupled receptors. The MC2-receptor (MC2-R) preferentially binds ACTH. It is expressed in the adrenal cortex and is hence considered to be the ACTH receptor. The MC5-receptor (MC5-R) binds ACTH...

journal_title：Endocrine research

authors： Liakos P,Chambaz EM,Feige JJ,Defaye G

更新日期：1998-08-01 00:00:00

abstract：:Excessive aldosterone secretion in some hypertensive patients may result from abnormal aldosterone synthase (AS) gene regulation in response to changes in dietary sodium intake. We have utilized NCI-H295 cells, which exhibit stable angiotensin-induced aldosterone secretion, for transient transfections with murine AS/h...

journal_title：Endocrine research

authors： Holland OB,Carr B,Brasier AR

更新日期：1995-02-01 00:00:00

abstract：:We have recently reported on the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK) and carbonic anhydrase I (CA-I) and II (CA-II) isoenzymes obtained from erythrocytes of healthy subjects and untreated patients with hyperthyroid diseases. Also, erythrocyte zinc concentrations were measured. Red b...

journal_title：Endocrine research

authors： Odçikin E,Ozdemir H,Ciftçi M,Capoğlu I

更新日期：2002-02-01 00:00:00

abstract：:Immunohistochemistry using a StAR peptide antiserum had previously revealed strong staining in rat and bovine adrenal medulla, suggesting the presence of a protein immunogenically related to StAR. Western blots of bovine medulla tissue homogenates showed the principal adrenal medullary immuno-reactive species to have ...

journal_title：Endocrine research

authors： Lo YC,MacKenzie SM,Howie AF,Apps DK,Mason JI,Williams BC,Morley SD

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To determine whether daily oral micronized progesterone affects bone turnover, as estimated by serum and urine biochemical markers, in postmenopausal women on long-term estrogen replacement therapy (ERT). METHODS:We recruited 14 women aged 65 or older to participate in a 9-week trial with micronized progestero...

journal_title：Endocrine research

authors： Azizi G,Hansen A,Prestwood KM

更新日期：2003-05-01 00:00:00

abstract：:In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...

journal_title：Endocrine research

authors： White PC,Hautanen A,Kupari M

更新日期：1998-08-01 00:00:00

abstract：:We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line. Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not. The MEK1 inhibitor PD98...

journal_title：Endocrine research

authors： LeHoux JG,Lefebvre A

更新日期：2004-11-01 00:00:00

abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...

journal_title：Endocrine research

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1994-05-01 00:00:00

abstract：:The action of peptide hormones from the anterior pituitary regulates transcription of a large number of genes located in most, if not all, tissues. This action is mediated through regulation of steroid hormone production in the steroidogenic factories (adrenals, gonads). These steroid hormones are transported through ...

journal_title：Endocrine research

authors： Waterman MR,Bischof LJ

更新日期：1996-11-01 00:00:00

abstract：:Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cell...

journal_title：Endocrine research

authors： Swart AC,Brown N,Kolar N,Swart P

更新日期：2000-11-01 00:00:00

abstract：:Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...

journal_title：Endocrine research

authors： White PC,Dupont B,New MI

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS:The study consisted of 52 newly treate...

journal_title：Endocrine research

authors： Ohishi T,Fujita T,Suzuki D,Nishida T,Yamamoto K,Okabayashi R,Ushirozako H,Banno T,Matsuyama Y

更新日期：2017-08-01 00:00:00

abstract：AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...

journal_title：Endocrine research

authors： Simental-Mendía LE,Simental-Mendía E,Rodríguez-Morán M,Guerrero-Romero F

更新日期：2017-02-01 00:00:00

abstract：:Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects a...

journal_title：Endocrine research

authors： Agarwal AK

更新日期：2003-11-01 00:00:00