Abstract:
:A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea level, was conducted in November, 1999. Serum levels of LH and T were also measured in these athletes following a 20 Km noncompetitive run. The air temperatures on the day of the experiment was comparable (25 degrees C in North and South Shouna versus 23 degrees C in Ramtha and Irbid). Before exercise, serum levels of LH and T in athletes of the below sea level environment (North and South Shouna) were similar to those levels in athletes of the above sea level environment (Ramtha and Irbid). Exercise caused a significant increase in serum levels of both LH and T only in athletes of North and South Shouna. It seems likely that the higher secretion of LH contributes, at least in part, for the higher serum levels of T following exercise. Taken together, these data suggest that exercise has an effect on LH and T secretion that is similar to that of fasting. And finally, the below sea level environmental factors, such as the high barometric pressure, as well as the genetic background of the athletes affect the pituitary and adrenal cortex as well as testicular tissue, resulting in the secretion of more LH and T.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Bani Hani I,El-Migdadi F,Shotar A,Abudheese R,Bashir Ndoi
10.1081/erc-100107165subject
Has Abstractpub_date
2001-02-01 00:00:00pages
19-23issue
1-2eissn
0743-5800issn
1532-4206journal_volume
27pub_type
杂志文章abstract::Diabetes mellitus impairs ventricular function, which itself may be disparately influenced by gender. This study compared the impact of gender on cardiac contractile response in ventricular myocytes from wild-type FVB and calmodulin-induced diabetic transgenic (OVE26) mice at young (2 month) and older (11 month) age. ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120022318
更新日期:2003-05-01 00:00:00
abstract::Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809309035409
更新日期:1993-03-01 00:00:00
abstract::Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808609035449
更新日期:1986-01-01 00:00:00
abstract::Y1 cells derived from mouse tumor zona fasciculata cells (ZF) were used to assess the importance of extracellular (EC) calcium availability via voltage-dependent calcium channels (VDCC) on steroidogenesis. The steroidogenic response to ACTH was investigated in the presence of blockers known to affect both calcium and ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043745
更新日期:1996-11-01 00:00:00
abstract::Plasminogen activator inhibitor-1 (PAI-1) levels were found to be associated with obesity, indicating that adipocytes might influence PAI-1 plasma levels. In addition, the 4G/5G promoter polymorphism of the PAI-1 gene possibly modulates PAI-1 gene transcription and, as a consequence, PAI-1 plasma levels. Metabolic par...
journal_title:Endocrine research
pub_type: 临床试验,杂志文章
doi:10.1081/erc-200035728
更新日期:2004-08-01 00:00:00
abstract::The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200043623
更新日期:2004-11-01 00:00:00
abstract::The enzyme 3beta-hydroxysteroid dehydrogenase plays a crucial role in the steroidogenic process in the adrenal gland. In the present study we tried to characterize its localization and developmental changes in the rat adrenal cortex during the postnatal period, using immunohistochemical methods. The development of the...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809909066126
更新日期:1999-02-01 00:00:00
abstract::There are two main regulatory sites of aldosterone biosynthesis, the early rate-limiting step by the P450scc and the final steps by the P450aldo. We have already demonstrated that, during gestation, activity and mRNA levels of P450aldo are increased. It has been shown that changes in sodium and potassium in the diet m...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032648
更新日期:1998-08-01 00:00:00
abstract::Purpose: Limited and contradictory data on the circulating levels of glucagon-like peptide (GLP-1) and resistin in hepatitis C virus genotype-4 (HCV-4) cirrhotic patients are present. Thus, this study aimed to evaluate their concentrations and to investigate the association between total GLP-1, resistin, and insulin r...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2019.1627551
更新日期:2020-02-01 00:00:00
abstract::Total collagen and its soluble fraction as well as water content were determined in late pregnancy in the uterine cervix in a population of 36 rats treated with progesterone (n = 10), mifepristone (n = 13) and controls (n = 13). In both treated groups there were no signs of delivery on the 21st day of gestation. Water...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809509030477
更新日期:1995-08-01 00:00:00
abstract::Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809509030493
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2014.913614
更新日期:2015-01-01 00:00:00
abstract::Pertussis toxin (PT) and cholera toxin (CT) have been shown to modulate lactogenic hormone-stimulated Nb2 cell mitogenesis, a lactogen-dependent cell line. As both toxins have been shown to alter guanylate cyclase activity in other cell systems, cyclic guanosine monophosphate (cGMP) analogs, 8-bromo or dibutyryl cGMP,...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209035926
更新日期:1992-01-01 00:00:00
abstract::Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808409036505
更新日期:1984-01-01 00:00:00
abstract::Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2013.875038
更新日期:2014-01-01 00:00:00
abstract::Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown. There is evidence for antiproliferative effects of DHEAS in neoplastic tissue. The present study was designed to investigate the effects of DHEAS on vascu...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200043956
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between th...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2011.640374
更新日期:2012-01-01 00:00:00
abstract::A 30-residue peptide corresponding to the amino acid sequence of steroidogenesis activator peptide (SAP) from rat Leydig tumor cells has been synthesized by the solid-phase method using Boc protection. SAP is the putative cycloheximide-sensitive, cAMP-regulated mediator of ACTH-stimulated conversion of cholesterol to ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809109027204
更新日期:1991-01-01 00:00:00
abstract::The effects of forskolin on the regulation of steroidogenesis and growth were examined in the Y1 adrenocortical tumor cell line, and the roles of cAMP and cAMP-dependent protein kinase in these actions of forskolin were evaluated. Forskolin, like corticotropin, stimulated steroidogenesis 3-fold and inhibited growth by...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808509032978
更新日期:1985-01-01 00:00:00
abstract::Background: Evidence has shown that low thyroid hormone levels may lead to worse prognosis including a higher mortality rate in patients with heart failure (HF). Thyroid replacement increases cardiac output and exercise performance without causing significant adverse events. The purpose of this study is to compare lev...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2019.1645165
更新日期:2020-02-01 00:00:00
abstract::Thyroid dysfunction influences the levels of Von Willebrand factor (VWF:Ag). Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels. A follow-up study of seven hyperthyroid patients undergoing anti-thyroid...
journal_title:Endocrine research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07435809309033019
更新日期:1993-01-01 00:00:00
abstract::Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secre...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032680
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastograph...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2011.633952
更新日期:2012-01-01 00:00:00
abstract::In general, growth hormone acts as a factor promoting cell proliferation in the positive direction and suppresses apoptosis. No report has described growth hormone (GH)-induced structural luteolysis. The present studies showed that GH induced structural luteolysis in rats after the induction of functional luteolysis b...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809909066140
更新日期:1999-05-01 00:00:00
abstract::It was the aim of this study to test for a possible effect of the new non ergot dopamine agonist CV 205-502 on plasma growth hormone (GH) concentrations in acromegaly. 10 acromegalic patients received a single oral dose of 150 micrograms CV 205-502 after an overnight fast. As a control group 7 acromegalic patients und...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809409035856
更新日期:1994-02-01 00:00:00
abstract::Several lines of evidence have suggested that the nuclear receptor Steroidogenic Factor-1 (SF-1 or Ad4BP) may be directly involved in the cAMP-dependent regulation of steroid hydroxylase genes in adrenocortical cells. In the bovine CYP17 gene, which encodes the cytochrome P450 17alpha-hydroxylase, an SF-1 site is pres...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032638
更新日期:1998-08-01 00:00:00
abstract::Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2019.1645163
更新日期:2020-02-01 00:00:00
abstract::Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809009033011
更新日期:1990-01-01 00:00:00
abstract::Neutrophils have an important role in the host defense. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. The causes of these impairments are not clear. We aimed to investigate changes of peripheral neutrophil counts and functions and their relatio...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809909066155
更新日期:1999-08-01 00:00:00
abstract::The steady state level of most cellular phosphoproteins is dependent on the relative catalytic activities of intracellular protein kinases and phosphatases. In adrenal cortex, ACTH acts through PKA activation and Ser/Tre phosphorylation. Phosphatases involved in this pathway are not completely described, particularly ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032618
更新日期:1998-08-01 00:00:00