Associations of small dense low-density lipoprotein and adiponectin with complications of type 2 diabetes.

Abstract:

BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications of diabetes, and also with plasma levels of adiponectin, were investigated in diabetic patients. METHODS:173 patients, with documented type 2 diabetes mellitus, were enrolled in this cross-sectional study. Laboratory, anthropometric, and clinical characteristics were all determined. The presence of CVD, hypertention, and microalbuminuria were also evaluated. Homeostasis model assessment of insulin resistance was calculated. RESULTS:Sd-LDL concentrations were significantly lower in patients with CVD than those without CVD (p = 0.020); and also lower in hypertensive patients relative to non-hypertensive ones (p = 0.008). Serum levels of adiponectin were significantly lower in patients with CVD (p < 0.001), and hypertension (p = 0.002), compared with those without each of these complications. Sd-LDL and adiponectin concentrations were positively correlated (r = 0.36, p < 0.001). Sd-LDL was also significantly associated with HbA1c (r = 0.24, p = 0.002). CONCLUSION:Our data suggest that decreased levels of adiponectin might be associated with developing complications of diabetes. This study did not provide any supportive results for the association of increased sd-LDL concentrations with CVD; neither for its association with other complications of diabetes.

journal_name

Endocr Res

journal_title

Endocrine research

authors

Esteghamati A,Asnafi S,Eslamian M,Noshad S,Nakhjavani M

doi

10.3109/07435800.2014.913614

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

14-9

issue

1

eissn

0743-5800

issn

1532-4206

journal_volume

40

pub_type

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