Thyrotropin as an independent factor of renal function and chronic kidney disease in normoglycemic euthyroid adults.

abstract：BACKGROUND:Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastograph...

journal_title：Endocrine research

authors： Mansor M,Okasha H,Esmat S,Hashem AM,Attia KA,El-din Hussein H

更新日期：2012-01-01 00:00:00

abstract：:The mechanisms by which SF-1 (Steroidogenic Factor-1) and Dax-1 (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome) dictate adrenal-specific transcriptional programs are the focus of this laboratory. SF-1-mediated transcription is upregulated by phosphorylation of serine 20...

journal_title：Endocrine research

authors： Babu PS,Bavers DL,Shah S,Hammer GD

更新日期：2000-11-01 00:00:00

abstract：:The CYP11B2 gene encodes aldosterone synthase, a cytochrome P450 (P450aldo) expressed in high levels in the adrenal zona glomerulosa. While the primary physiologic regulators of aldosterone production are circulating angiotensin II (Ang II) and potassium (K+) the action of these agents on CYP11B2 gene transcription ha...

journal_title：Endocrine research

authors： Clyne CD,White PC,Rainey WE

更新日期：1996-11-01 00:00:00

abstract：:In general, growth hormone acts as a factor promoting cell proliferation in the positive direction and suppresses apoptosis. No report has described growth hormone (GH)-induced structural luteolysis. The present studies showed that GH induced structural luteolysis in rats after the induction of functional luteolysis b...

journal_title：Endocrine research

authors： Kiya T,Endo T,Henmi H,Goto T,Kitajima Y,Manase K,Takahashi S,Kudo R

更新日期：1999-05-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：:The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor. For estrogen receptor, proteasome inhibition decreases ligand-mediated transcription. We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in...

journal_title：Endocrine research

authors： Yokota K,Shibata H,Kobayashi S,Suda N,Murai A,Kurihara I,Saito I,Saruta T

更新日期：2004-11-01 00:00:00

abstract：:In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...

journal_title：Endocrine research

authors： Bieńkiewicz A,Pajszczyk-Kieszkiewicz T,Kuś E,Dabrowski R

更新日期：1994-11-01 00:00:00

abstract：:Four hundred micrograms of synthetic thyrotropin releasing hormone (TRH) were given intravenously to 4 normal men and 4 normal women, and four weeks later, 1000 micrograms of TRH were administered intravenously to 4 of the 8 individuals and oxytocin (OT) was measured in plasma on both occasions. Following injection of...

journal_title：Endocrine research

authors： Amico JA,Johnston JM

更新日期：1985-01-01 00:00:00

abstract：:Metabolic syndrome was first proposed in 1988 and has been recognized as a powerful predictor for cardiovascular disease and diabetes. At the same time, white blood cell count (WBCC) was proposed to have significant correlation with metabolic syndrome (MS). In this study, we attempted to investigate the relationship b...

journal_title：Endocrine research

authors： Chuo SK,Li JC,Tsai WC,Wu DA,Kuo SW,Pei D,Chen SP,Shen DC

更新日期：2005-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secre...

journal_title：Endocrine research

authors： Mathieu MN,Hamroun D,Pouzeratte Y,Guérineau NC,Guillon G,Chevillard C

更新日期：1998-08-01 00:00:00

abstract：:Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...

journal_title：Endocrine research

authors： Kawai Y,Clark MR

更新日期：1986-01-01 00:00:00

abstract：:Hippocampal functions are influenced by steroid hormones, such as testosterone and estradiol. It has been demonstrated that hippocampus-derived steroid hormones play important roles in neuronal protection and synapse formation. Our research groups have demonstrated that estradiol is de novo synthesized in the rat hipp...

journal_title：Endocrine research

authors： Munetsuna E,Hattori M,Yamazaki T

更新日期：2014-01-01 00:00:00

abstract：:There are striking similarities between Cushing's syndrome and the 'metabolic syndrome X' since both are characterised by hypertension, insulin resistance, glucose intolerance, hyperlipidaemia, and central obesity. The possibility that cortisol contributes to the associations between multiple risk factors for cardiova...

journal_title：Endocrine research

authors： Walker BR

更新日期：1996-11-01 00:00:00

abstract：:Combined partial deficiency of 17alpha-hydroxylase and 21-hydroxylase activities was first described in 1985; however the genes for P450c17 and P450c21 in these patients lack mutations. In 1986 we postulated that this disorder might be due to mutations in P450 oxidoreductase (POR), the flavoprotein that donates electr...

journal_title：Endocrine research

authors： Pandey AV,Flück CE,Huang N,Tajima T,Fujieda K,Miller WL

更新日期：2004-11-01 00:00:00

abstract：:T3 receptors are ligand-dependent transcriptional activators that can stimulate gene expression resulting in growth and development. In this study T3 binding sites on isolated liver nuclei are demonstrated in the teleost Anabas testudineus. The effect of hypothyroidism and feeding of polyunsaturated fatty acids (PUFA)...

journal_title：Endocrine research

authors： Shameena B,Renuka TR,Varghese S,Paulose CS,Oommen OV

更新日期：2001-08-01 00:00:00

abstract：:Neutrophils have an important role in the host defense. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. The causes of these impairments are not clear. We aimed to investigate changes of peripheral neutrophil counts and functions and their relatio...

journal_title：Endocrine research

authors： Cantürk Z,Cantürk NZ,Cetinarslan B,Erçin C,Dökmetaş S,Sencan M

更新日期：1999-08-01 00:00:00

abstract：:The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...

journal_title：Endocrine research

authors： Keramidas M,Feige JJ,Thomas M

更新日期：2004-11-01 00:00:00

abstract：:We studied whether the activation of rat brown adipose tissue (BAT) by cold exposure or by the administration of beta-3-noradrenergic agonist CGP-12177 could be prevented by the inhibition of thyroxine (T4) to triiodothyronine (T3) conversion. Hypothyroid rats were treated with replacement doses of T4, T4 plus iopanoi...

journal_title：Endocrine research

authors： Zaninovich AA,Rebagliati I,Raíces M,Ricci C,Hagmüller K

更新日期：2000-05-01 00:00:00

abstract：:Y1 cells derived from mouse tumor zona fasciculata cells (ZF) were used to assess the importance of extracellular (EC) calcium availability via voltage-dependent calcium channels (VDCC) on steroidogenesis. The steroidogenic response to ACTH was investigated in the presence of blockers known to affect both calcium and ...

journal_title：Endocrine research

authors： Coyne MD,Wang G,Lemos JR

更新日期：1996-11-01 00:00:00

abstract：:Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...

journal_title：Endocrine research

authors： Pon LA,Epstein LF,Orme-Johnson NR

更新日期：1986-01-01 00:00:00

abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...

journal_title：Endocrine research

authors： Wynn J,Shah U,Murray SA

更新日期：2002-11-01 00:00:00

abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase plays a crucial role in the steroidogenic process in the adrenal gland. In the present study we tried to characterize its localization and developmental changes in the rat adrenal cortex during the postnatal period, using immunohistochemical methods. The development of the...

journal_title：Endocrine research

authors： Pignatelli D,Bento MJ,Maia M,Magalhães MM,Magalhães MC,Mason JI

更新日期：1999-02-01 00:00:00

abstract：:Sutherlandia frutescens (Cancer bush), a Southern African indigenous plant, is traditionally used to treat stress related maladies linked to the endocrine system. Extracts of the shrub were used to investigate the claimed stress-relieving properties of the shrub. Dysregulation of the stress response is associated with...

journal_title：Endocrine research

authors： Prevoo D,Smith C,Swart P,Swart AC

更新日期：2004-11-01 00:00:00

abstract：:Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...

journal_title：Endocrine research

authors： Stevic MS,Stefanic M,Tokic S,Glavas-Obrovac L,Mihaljevic S,Karner I

更新日期：2014-01-01 00:00:00

abstract：:The steady state level of most cellular phosphoproteins is dependent on the relative catalytic activities of intracellular protein kinases and phosphatases. In adrenal cortex, ACTH acts through PKA activation and Ser/Tre phosphorylation. Phosphatases involved in this pathway are not completely described, particularly ...

journal_title：Endocrine research

authors： Cornejo Maciel F,Paz C,Neuman MI,Podestá EJ

更新日期：1998-08-01 00:00:00

abstract：:The effect of crowding on the pituitary-gonadal axis was studied in adult male rats. Crowding reduced body weight gain, did not alter relative adrenal weight and increased relative testis weight. Neither basal levels of corticosterone nor its response to acute stress were altered by crowding. Likewise, LH secretion wa...

journal_title：Endocrine research

authors： Armario A,Lopez-Calderón A

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determin...

journal_title：Endocrine research

authors： Calan M,Kume T,Yilmaz O,Arkan T,Kocabas GU,Dokuzlar O,Aygün K,Oktan MA,Danıs N,Temur M

更新日期：2016-08-01 00:00:00

abstract：:Purpose: Limited and contradictory data on the circulating levels of glucagon-like peptide (GLP-1) and resistin in hepatitis C virus genotype-4 (HCV-4) cirrhotic patients are present. Thus, this study aimed to evaluate their concentrations and to investigate the association between total GLP-1, resistin, and insulin r...

journal_title：Endocrine research

authors： Ibrahim DM,Shaaban ESE,Fouad TA

更新日期：2020-02-01 00:00:00

abstract：:A study was conducted to provide information on the characteristics of skeletal muscle glucocorticoid receptors and to determine the response of serum cortisol and thyroxine secretion to colostrum feeding in the neonatal calf. Twenty-four calves (12 males and 12 females) were obtained immediately postpartum and random...

journal_title：Endocrine research

authors： Waggoner DK,McCarthy FD,Akers RM

更新日期：1988-01-01 00:00:00

abstract：:The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in...

journal_title：Endocrine research

authors： Bicknell AB

更新日期：2002-11-01 00:00:00