Abstract:
:Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secreting cells by other cells, we also used the human adrenocortical cell line H295R, which was shown to produce steroids. This cell line also expressed preproET-1-RNA and released mature ET. Functional ET receptors were shown on H295R and cultured human adrenocortical cells. These findings indicate that adrenal steroid-secreting cells synthesize and release ET-1, raising the possibility for an autocrine-paracrine effect of ET-1 on adrenocortical functions.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Mathieu MN,Hamroun D,Pouzeratte Y,Guérineau NC,Guillon G,Chevillard Cdoi
10.3109/07435809809032680subject
Has Abstractpub_date
1998-08-01 00:00:00pages
743-7issue
3-4eissn
0743-5800issn
1532-4206journal_volume
24pub_type
杂志文章abstract::Sutherlandia frutescens (Cancer bush), a Southern African indigenous plant, is traditionally used to treat stress related maladies linked to the endocrine system. Extracts of the shrub were used to investigate the claimed stress-relieving properties of the shrub. Dysregulation of the stress response is associated with...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200044020
更新日期:2004-11-01 00:00:00
abstract::Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809509030493
更新日期:1995-11-01 00:00:00
abstract::Y1 adrenocortical tumor cells possess amplified and overexpressed c-Ki-ras proto-oncogene, displaying chronic high levels of the c-Ki-Ras-GTP protein. Despite this oncogenic lesion, we previously reported that Y1 cells retain tight regulatory mechanisms of cell cycle control typified by the mitogenic response triggere...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200043600
更新日期:2004-11-01 00:00:00
abstract::Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...
journal_title:Endocrine research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07435800009048561
更新日期:2000-11-01 00:00:00
abstract::Recent studies from our laboratory have shown that human chorionic gonadotropin (hCG), human luteinizing hormone (hLH), and CG-like proteins from Xanthomonas maltophilia (xCG) and Candida albicans (CaCGLP) induce Candida albicans transition from blastospores to hyphal forms. Xanthomonas maltophilia CG-like protein (xC...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809409035852
更新日期:1994-02-01 00:00:00
abstract::Cerebrovascular accidents are one of the life-threatening complications of diabetic ketoacidosis (DKA) in children and adolescents. Our objective was to evaluate the effect of DKA and its treatment on factors known to affect thrombotic activity (protein C; protein S; von Willebrand factor, fibrinogen; homocysteine; an...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120018678
更新日期:2003-02-01 00:00:00
abstract::Purpose: Transthyretin (TTR) is a protein with a growing number of biological functions in addition to its well-established binding and circulatory transport of thyroxine, and indirect retinoid transport through interaction with retinol-binding protein. Misfolded and aggregated wild-type and mutant TTRs are involved i...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2019.1694538
更新日期:2020-01-01 00:00:00
abstract::Islets derived from patients with persistent hyperinsulinemic hypoglycemia of infancy, PHHI, show a significant capacity to proliferate in vitro without the addition of growth factors. However, as with other differentiated cells, PHHI-derived islet cells show a loss of differentiated function with repeated subculture....
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800500229235
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Increasing evidence exists that hyperprolactinemia alters metabolic profile. The mechanism of this effect is unknown. We aimed to investigate the differences between the metabolic profile of patients with prolactinomas and nonfunctional pituitary adenomas and to evaluate the impact of other pituitary hormones o...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2015.1135444
更新日期:2016-08-01 00:00:00
abstract::The effects of forskolin on the regulation of steroidogenesis and growth were examined in the Y1 adrenocortical tumor cell line, and the roles of cAMP and cAMP-dependent protein kinase in these actions of forskolin were evaluated. Forskolin, like corticotropin, stimulated steroidogenesis 3-fold and inhibited growth by...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808509032978
更新日期:1985-01-01 00:00:00
abstract::Steroid 21-hydroxylase deficiency is the most frequent cause of congenital adrenal hyperplasia, an inherited inability to synthesize cortisol. Mutations causing this disorder have been characterized by hybridization analysis of patient DNA samples using cDNA and oligonucleotide probes, and by cloning and sequencing of...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808909039099
更新日期:1989-01-01 00:00:00
abstract::This study was performed on 18 postmenopausal female volunteers in order to examine changes in sex hormone binding globulin (SHBG), high density lipoprotein cholesterol (HDLC), total cholesterol (TC) and serum triglyceride (TG) levels in a period of four months of moderate physical exercise. While SHBG decreased signi...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209111036
更新日期:1992-01-01 00:00:00
abstract::Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808709035466
更新日期:1987-01-01 00:00:00
abstract::There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement th...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-100107870
更新日期:2001-11-01 00:00:00
abstract::In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120016983
更新日期:2002-11-01 00:00:00
abstract::X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120016999
更新日期:2002-11-01 00:00:00
abstract:INTRODUCTION:Impairments in neuroendocrine regulation of food intake and postprandial satiety are leading causes to obesity. Ghrelin peptide is a GI hormone known to increase food intake partly through induction of growth hormone. The regulation of ghrelin production is still unknown. OBJECTIVE:The aim of the current ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2013.799484
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to investigate the association between plasma homocysteine (Hcy) levels and carotid, cardiac, and renal end-organ damage in newly diagnosed type 2 diabetes mellitus (T2DM) patients. METHODS:Newly diagnosed normotensive T2DM patients (n = 390) were enrolled in this study. The pa...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2016.1171235
更新日期:2017-02-01 00:00:00
abstract:UNLABELLED:It remains difficult to pre-operatively differentiate follicular carcinoma and adenoma even under intraoperative investigations including histopathologic diagnosis of frozen sections. METHODS:We retrospectively compared dual phase thallium (Tl-201) thyroid scan and fine-needle aspiration (FNA) cytology to d...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120025036
更新日期:2003-08-01 00:00:00
abstract::The presence of vasoactive intestinal peptide and neuropeptide Y in thyroid nerves and their effects on thyroid blood flow are well known. However, the effects of these two neuropeptides on the various processes involved in thyroid hormone biosynthesis and release have not been fully explored. We have now tested these...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209026678
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to examine the effects of exercise on anterior pituitary hormones (adrenocorticotropic hormone (ACTH), leutinizing hormone (LH) and growth hormone) as well as on cortisol at low altitude (350 meters below the sea level) and to compare these effects with those at a moderate level altitude ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809609030513
更新日期:1996-08-01 00:00:00
abstract::Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cell...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048632
更新日期:2000-11-01 00:00:00
abstract::The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032720
更新日期:1998-08-01 00:00:00
abstract::Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2018.1470639
更新日期:2018-11-01 00:00:00
abstract::In the guinea pig adrenal the cells of the outer zone secrete high levels of steroid and respond to ACTH with increased synthesis of cholesterol and steroid. The outer zone consists of two cell types: zona fasciculata (ZF) and zona glomerulosa (ZG). To determine the relative contribution of ZF and ZG to the outer zone...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809109027197
更新日期:1991-01-01 00:00:00
abstract::Y1 cells derived from mouse tumor zona fasciculata cells (ZF) were used to assess the importance of extracellular (EC) calcium availability via voltage-dependent calcium channels (VDCC) on steroidogenesis. The steroidogenic response to ACTH was investigated in the presence of blockers known to affect both calcium and ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043745
更新日期:1996-11-01 00:00:00
abstract::Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048616
更新日期:2000-11-01 00:00:00
abstract::Using Western blot analysis we found transcriptional co-repressor Sin3A to be expressed at a higher level in male mouse kidney than in females. HDAC1 (histone deacetylase 1) protein, another co-repressor forming complexes with Sin3A, was not higher in males. No sex differences in Sin3A expression were found after gona...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800500229243
更新日期:2005-01-01 00:00:00
abstract::T3 receptors are ligand-dependent transcriptional activators that can stimulate gene expression resulting in growth and development. In this study T3 binding sites on isolated liver nuclei are demonstrated in the teleost Anabas testudineus. The effect of hypothyroidism and feeding of polyunsaturated fatty acids (PUFA)...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-100106010
更新日期:2001-08-01 00:00:00
abstract::Progesterone (P) given intramuscularly increases renal sodium excretion. We tested the in vitro capacity of P to bind to the human mineralocorticoid receptor (MR) with a reticulocyte lysate system and Ps transactivation potency in transfected CV-1 cells. Progesterone binds with higher affinity to the MR than aldostero...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120016824
更新日期:2002-11-01 00:00:00