Baboon cytochrome P450c11 is encoded by more than one gene.

Abstract:

:Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cells and the metabolism of deoxycorticosterone to corticosterone investigated. The expressed enzyme exhibited 1 beta hydroxylase activity, but no aldosterone synthase activity.

journal_name

Endocr Res

journal_title

Endocrine research

authors

Swart AC,Brown N,Kolar N,Swart P

doi

10.3109/07435800009048632

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1011-8

issue

4

eissn

0743-5800

issn

1532-4206

journal_volume

26

pub_type

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