Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells.

abstract：OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...

journal_title：Endocrine research

authors： Kutoh E,Hori T

更新日期：2013-08-01 00:00:00

abstract：:Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...

journal_title：Endocrine research

authors： Forti FL,Armelin HA

更新日期：2000-11-01 00:00:00

abstract：:The present work was to study if the alpha-melanocyte-stimulating hormone (alpha-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracereb...

journal_title：Endocrine research

authors： Vecsernyés M,Biró E,Gardi J,Julesz J,Telegdy G

更新日期：2000-08-01 00:00:00

abstract：:Metabolic syndrome was first proposed in 1988 and has been recognized as a powerful predictor for cardiovascular disease and diabetes. At the same time, white blood cell count (WBCC) was proposed to have significant correlation with metabolic syndrome (MS). In this study, we attempted to investigate the relationship b...

journal_title：Endocrine research

authors： Chuo SK,Li JC,Tsai WC,Wu DA,Kuo SW,Pei D,Chen SP,Shen DC

更新日期：2005-01-01 00:00:00

abstract：:Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown. There is evidence for antiproliferative effects of DHEAS in neoplastic tissue. The present study was designed to investigate the effects of DHEAS on vascu...

journal_title：Endocrine research

authors： Hinson JP,Khan M

更新日期：2004-11-01 00:00:00

abstract：:A study was conducted to provide information on the characteristics of skeletal muscle glucocorticoid receptors and to determine the response of serum cortisol and thyroxine secretion to colostrum feeding in the neonatal calf. Twenty-four calves (12 males and 12 females) were obtained immediately postpartum and random...

journal_title：Endocrine research

authors： Waggoner DK,McCarthy FD,Akers RM

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a cri...

journal_title：Endocrine research

authors： Karakose M,Caliskan M,Arslan MS,Demirci T,Karakose S,Tutal E,Cakal E

更新日期：2018-02-01 00:00:00

abstract：:Type 1 angiotensin II (AII) receptors (AT1 receptors), besides stimulation of aldosterone secretion, seem to transduce the growth factor-like activity of AII on glomerulosa cells. Although a local renin-angiotensin system and AII synthesis have been found in human adrenals and aldosteronomas, it is unclear whether ald...

journal_title：Endocrine research

authors： Sarzani R,Opocher G,Dessì-Fulgheri P,Paci V,Cola G,Rocco S,Vianello B,Mantero F,Rappelli A

更新日期：1995-02-01 00:00:00

abstract：:The enzyme, 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase (3 beta-HSD) is an essential element in the biosynthetic pathway for potent adrenal steroid hormones that appear to regulate maturation of many tissues in utero and are critical for homeostasis after birth. The results of prior studies are suggestive ...

journal_title：Endocrine research

authors： Parker CR Jr,Faye-Petersen O,Stankovic AK,Mason JI,Grizzle WE

更新日期：1995-02-01 00:00:00

abstract：:Thyroid dysfunction influences the levels of Von Willebrand factor (VWF:Ag). Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels. A follow-up study of seven hyperthyroid patients undergoing anti-thyroid...

journal_title：Endocrine research

authors： Liu L,Wang X,Lin Z,Wu H

更新日期：1993-01-01 00:00:00

abstract：:Adrenal computed tomography with determination of Hounsfield units has proved to be sensitive and specific in the differential diagnosis of benign vs. malign adrenal lesions. On the other hand, computed tomography may fail in patients with small adrenal masses of less than 1.0 cm. However, especially in patients with ...

journal_title：Endocrine research

authors： Willenberg HS,Mansmann G,Fritzen R,Schott M,Feldkamp J,Schulte HM,Scherbaum WA,Bornstein SR

更新日期：2002-11-01 00:00:00

abstract：AIM:To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D). MATERIALS AND METHODS:Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked...

journal_title：Endocrine research

authors： Sakly W,Mankaï A,Achour A,Thabet Y,Ouertani M,Boughammoura L,Harbi A,Chaieb L,Sfar MT,Ghedira I

更新日期：2012-01-01 00:00:00

abstract：:We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line. Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not. The MEK1 inhibitor PD98...

journal_title：Endocrine research

authors： LeHoux JG,Lefebvre A

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:The scavenger receptor class B type I (SR-BI) is a key component in the reverse cholesterol transportation. The aim of this study was to assess the association between exon1 (G → A) polymorphism of SR-BI gene and lipid profiles among the Tehran Lipid and Glucose Study (TLGS) population. MATERIALS AND METH...

journal_title：Endocrine research

authors： Faam B,Daneshpour MS,Hedayati M,Halalkhor S,Mansournia MA,Zarkesh M,Azizi F

更新日期：2014-01-01 00:00:00

abstract：:Two distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) with respect to enzymatic activity were identified in the ovine liver and kidney. 11 beta-HSD1 (the hepatic isoform) was reversible and NADP(H)-dependent. By contrast, 11 beta-HSD2 (the renal isoform) was unidirectional and NAD-dependent. Ovin...

journal_title：Endocrine research

authors： Yang K

更新日期：1995-02-01 00:00:00

abstract：:The secretory activity of the adrenal gland is mainly regulated by peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now increasing evidence that local factors, including neuropeptides and neurotransmitters, can also participate in the control of adrenocortical cells. In particular, serotonin (5-...

journal_title：Endocrine research

authors： Delarue C,Contesse V,Lefebvre H,Lenglet S,Grumolato L,Kuhn JM,Vaudry H

更新日期：1998-08-01 00:00:00

abstract：:We report a novel mutant of the luteinizing hormone receptor (LHR) in a case of familial Leydig cell hypoplasia and pseudohermaphrotidism. The proband was homozygous for two missense mutations, T1121C and C1175T, causing substitutions I374T and T3921. The molecular effects of the mutations were investigated by heterol...

journal_title：Endocrine research

authors： Pals-Rylaarsdam R,Liu G,Brickman W,Duranteau L,Monroe J,El-Awady MK,Gad YZ,Shenker A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...

journal_title：Endocrine research

authors： Karbownik M,Zasada K,Wyczechowska D,Lewiński A,Fabianowska-Majewska K

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:Adiponectin and chemerin have been reported their associations with insulin resistance and chronic inflammation. However, the relationship between adiponectin and chemerin themselves has not been fully elucidated. Therefore, we investigated the effects of changes in adiponectin and chemerin levels after a weigh...

journal_title：Endocrine research

authors： Shin HY,Park S,Lee JW

更新日期：2017-11-01 00:00:00

abstract：:The effect of crowding on the pituitary-gonadal axis was studied in adult male rats. Crowding reduced body weight gain, did not alter relative adrenal weight and increased relative testis weight. Neither basal levels of corticosterone nor its response to acute stress were altered by crowding. Likewise, LH secretion wa...

journal_title：Endocrine research

authors： Armario A,Lopez-Calderón A

更新日期：1986-01-01 00:00:00

abstract：:In order to clarify the roles of cholinergic and serotonergic neurotransmission in the mediation of exercise-induced growth hormone (GH) release, normal young volunteers of both sexes were studied. Exercise was for 20 minutes at 800 kpm for the men and 500 kpm for the women. Pretreatment with 0.4 mg atropine 1 hour pr...

journal_title：Endocrine research

authors： Brillon D,Nabil N,Jacobs LS

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications ...

journal_title：Endocrine research

authors： Esteghamati A,Asnafi S,Eslamian M,Noshad S,Nakhjavani M

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes in the elderly people. Previous studies have reported the sex differences in risk for type 2 diabetes, especially in the elderly people, whereas reasons for these sex differences remain poorly understood...

journal_title：Endocrine research

authors： Li T,Jiao W,Li W,Li H

更新日期：2016-08-01 00:00:00

abstract：:Combined partial deficiency of 17alpha-hydroxylase and 21-hydroxylase activities was first described in 1985; however the genes for P450c17 and P450c21 in these patients lack mutations. In 1986 we postulated that this disorder might be due to mutations in P450 oxidoreductase (POR), the flavoprotein that donates electr...

journal_title：Endocrine research

authors： Pandey AV,Flück CE,Huang N,Tajima T,Fujieda K,Miller WL

更新日期：2004-11-01 00:00:00

abstract：:Comparison of binding of 125I-porcine FSH to porcine granulosa cells from small and large ovarian follicles indicated that binding is dependent on both time and temperature. At 37 C, binding of ligand is more than four times higher in cells from small follicles than in cells from large follicles within 30 minutes of t...

journal_title：Endocrine research

authors： LaBarbera AR

更新日期：1994-02-01 00:00:00

abstract：:The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...

journal_title：Endocrine research

authors： Keramidas M,Feige JJ,Thomas M

更新日期：2004-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS:The study consisted of 52 newly treate...

journal_title：Endocrine research

authors： Ohishi T,Fujita T,Suzuki D,Nishida T,Yamamoto K,Okabayashi R,Ushirozako H,Banno T,Matsuyama Y

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:Absract Purpose: Mutations in the TPO gene have been reported to cause congenital hypothyroidism (CH), and our aim in this study was to determine the genetic basis of congenital hypothyroidism in two affected children coming from a consanguineous family. METHODS:Since CH is usually inherited in autosomal re...

journal_title：Endocrine research

authors： Cangul H,Darendeliler F,Saglam Y,Kucukemre B,Kendall M,Boelaert K,Barrett TG,Maher ER

更新日期：2015-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...

journal_title：Endocrine research

authors： Miller HA 3rd,Southerland CM

更新日期：1990-01-01 00:00:00