Abstract:
:The secretory activity of the adrenal gland is mainly regulated by peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now increasing evidence that local factors, including neuropeptides and neurotransmitters, can also participate in the control of adrenocortical cells. In particular, serotonin (5-HT), produced by adrenochromaffin cells in frog and rat as well as by mast cells in the adrenal gland of rat and human, stimulates corticosteroid secretion. In both frog and human adrenal gland, the benzamide derivative (R,S)-zacopride induces a robust increase in corticosteroid release suggesting that the effect of 5-HT on steroidogenesis is mediated through activation of 5-HT4 receptors. In contrast, in rat, the stimulatory effect of 5-HT on aldosterone secretion is clearly not mediated by 5-HT4 receptors. In all three species, incubation of adrenocortical fragments with 5-HT induces a significant increase in cAMP formation. Our data suggest that 5-HT, released within the adrenal cortex, may act as a paracrine factor to stimulate steroid secretion. Although the corticotropic effect of 5-HT has been conserved from amphibians to primates, the type of receptors involved in the action of 5-HT markedly differs across species.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Delarue C,Contesse V,Lefebvre H,Lenglet S,Grumolato L,Kuhn JM,Vaudry Hdoi
10.3109/07435809809032670subject
Has Abstractpub_date
1998-08-01 00:00:00pages
687-94issue
3-4eissn
0743-5800issn
1532-4206journal_volume
24pub_type
杂志文章abstract::A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea ...
journal_title:Endocrine research
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journal_title:Endocrine research
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abstract::Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2013.875038
更新日期:2014-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809609030513
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2014.913614
更新日期:2015-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048594
更新日期:2000-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2012.745128
更新日期:2013-08-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809709031859
更新日期:1997-11-01 00:00:00
abstract::In a previous study we demonstrated a significant increase of CD5+ B subset in patients with Graves' disease (GD) compared with normal controls. The aim of this study was to compare the percentage of CD5+ B and CD5- B cells in GD with that in different forms of autoimmune and non immune-mediated thyroid diseases. Seve...
journal_title:Endocrine research
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808809032983
更新日期:1988-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808509035426
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journal_title:Endocrine research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章,评审
doi:10.3109/07435800.2013.778865
更新日期:2013-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048606
更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/07435800903204082
更新日期:2009-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809509030462
更新日期:1995-02-01 00:00:00
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journal_title:Endocrine research
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更新日期:2016-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120025036
更新日期:2003-08-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2017.1300808
更新日期:2017-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043786
更新日期:1996-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200044048
更新日期:2004-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2016.1141936
更新日期:2016-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809509030425
更新日期:1995-02-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800500229235
更新日期:2005-01-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009066172
更新日期:2000-08-01 00:00:00
abstract::In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809409030414
更新日期:1994-11-01 00:00:00