Abstract:
BACKGROUND:Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. OBJECTIVE:The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpublished mRNA experiments for evidence that these agents affect the early inflammatory response, perhaps through actions on specific cytokines and chemokines. RESULTS AND DISCUSSION:Tetrac and Nanotetrac inhibit expression in tumor cells of cytokine genes, e.g., specific interleukins, and chemokine genes, such as fractalkine (CX3CL1), and chemokine receptor genes (CX3CR1) that have been identified as high priority targets in the development of inflammation-suppressant drugs. The possibility is also examined that tetrac formulations have an effect on the function of inflammatory cells.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Davis PJ,Glinsky GV,Lin HY,Incerpi S,Davis FB,Mousa SA,Tang HY,Hercbergs A,Luidens MKdoi
10.3109/07435800.2013.778865subject
Has Abstractpub_date
2013-01-01 00:00:00pages
112-8issue
2eissn
0743-5800issn
1532-4206journal_volume
38pub_type
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journal_title:Endocrine research
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