Gonadotropins Are Related to Lean Mass in Healthy Postmenopausal Women.

Abstract:

BACKGROUND:It has been suggested that the changes in hormone levels that occur with menopause and aging are related to loss of muscle mass. However, the role of gonadotropins in this process is unknown. OBJECTIVES:To analyze the relationship between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and lean mass in a cohort of healthy women. METHODS:This is a cross-sectional study including 91 postmenopausal women (48-65 years old). Serum FSH, LH, and estradiol (E2) were measured. Lean mass was estimated by bioelectrical impedance analysis and expressed as appendicular skeletal muscle mass (AMM) index. RESULTS:AMM index was negatively correlated with FSH levels (r = -0.33, p = 0.001) and LH (r = -0.293, p = 0.005), while there was no association with E2. When muscle mass expressed as AMM index was stratified into tertiles, there were significant differences between the lowest and the highest tertile for both FSH (82.4 ± 30, vs. 67.9 ± 25.8 mIU/mL, p = 0.04) and LH (40.9 ± 15.2 vs. 36.1 ± 12.3 mIU/mL, p = 0.03). In logistic regression analysis adjusted for age and E2 levels, high concentrations of FSH (OR = 1.03, 95% CI = 1.01-1.05, p = 0.008) and LH (OR = 1.06, 95% CI = 1.01-1.1, p = 0.01) were risk factors for having lower lean mass expressed as AMM index. CONCLUSIONS:Menopausal women with high levels of gonadotropins have lower levels of lean mass than those with lower gonadotropins levels.

journal_name

Endocr Res

journal_title

Endocrine research

authors

García-Martín A,Reyes-García R,García-Castro JM,Muñoz-Garach A,Escobar-Jiménez F,Muñoz-Torres M

doi

10.3109/07435800.2012.733987

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

119-124

issue

3

eissn

0743-5800

issn

1532-4206

journal_volume

38

pub_type

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