Association between plasma homocysteine levels and end-organ damage in newly diagnosed type 2 diabetes mellitus patients.

abstract：UNLABELLED:Absract Purpose: Mutations in the TPO gene have been reported to cause congenital hypothyroidism (CH), and our aim in this study was to determine the genetic basis of congenital hypothyroidism in two affected children coming from a consanguineous family. METHODS:Since CH is usually inherited in autosomal re...

journal_title：Endocrine research

authors： Cangul H,Darendeliler F,Saglam Y,Kucukemre B,Kendall M,Boelaert K,Barrett TG,Maher ER

更新日期：2015-01-01 00:00:00

abstract：:The secretory activity of the adrenal gland is mainly regulated by peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now increasing evidence that local factors, including neuropeptides and neurotransmitters, can also participate in the control of adrenocortical cells. In particular, serotonin (5-...

journal_title：Endocrine research

authors： Delarue C,Contesse V,Lefebvre H,Lenglet S,Grumolato L,Kuhn JM,Vaudry H

更新日期：1998-08-01 00:00:00

abstract：:Purpose: Transthyretin (TTR) is a protein with a growing number of biological functions in addition to its well-established binding and circulatory transport of thyroxine, and indirect retinoid transport through interaction with retinol-binding protein. Misfolded and aggregated wild-type and mutant TTRs are involved i...

journal_title：Endocrine research

authors： Fong VH,Wong S,Jintaridhi P,Vieira A

更新日期：2020-01-01 00:00:00

abstract：:The present work was to study if the alpha-melanocyte-stimulating hormone (alpha-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracereb...

journal_title：Endocrine research

authors： Vecsernyés M,Biró E,Gardi J,Julesz J,Telegdy G

更新日期：2000-08-01 00:00:00

abstract：:It was the aim of this study to test for a possible effect of the new non ergot dopamine agonist CV 205-502 on plasma growth hormone (GH) concentrations in acromegaly. 10 acromegalic patients received a single oral dose of 150 micrograms CV 205-502 after an overnight fast. As a control group 7 acromegalic patients und...

journal_title：Endocrine research

authors： Svoboda T,Kotzmann H,Clodi M,Bernecker P,Geyer G,Luger A

更新日期：1994-02-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：:The liver is known to be sensitive to dietary challenge and to reduction in its functional mass. To investigate the influence of the vitamin D endocrine system on the hepatic growth response, liver DNA synthesis (S phase of cell cycle) was primed by dietary manipulation (high carbohydrate/protein-free diet x 3 d follo...

journal_title：Endocrine research

authors： Ethier C,Goupil D,Gascon-Barré M

更新日期：1991-01-01 00:00:00

abstract：:Immunohistochemistry using a StAR peptide antiserum had previously revealed strong staining in rat and bovine adrenal medulla, suggesting the presence of a protein immunogenically related to StAR. Western blots of bovine medulla tissue homogenates showed the principal adrenal medullary immuno-reactive species to have ...

journal_title：Endocrine research

authors： Lo YC,MacKenzie SM,Howie AF,Apps DK,Mason JI,Williams BC,Morley SD

更新日期：2000-11-01 00:00:00

abstract：INTRODUCTION:Impairments in neuroendocrine regulation of food intake and postprandial satiety are leading causes to obesity. Ghrelin peptide is a GI hormone known to increase food intake partly through induction of growth hormone. The regulation of ghrelin production is still unknown. OBJECTIVE:The aim of the current ...

journal_title：Endocrine research

authors： Haddad H,Mroueh M,Faour WH,Daher C

更新日期：2014-01-01 00:00:00

abstract：:Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...

journal_title：Endocrine research

authors： Daussac A,Barat P,Servant N,Yacoub M,Missonier S,Lavran F,Gaspari L,Sultan C,Paris F

更新日期：2020-02-01 00:00:00

abstract：:Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...

journal_title：Endocrine research

authors： White PC,Dupont B,New MI

更新日期：1984-01-01 00:00:00

abstract：:The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...

journal_title：Endocrine research

authors： Pignatelli D,Leitão D,Maia M,Schmidt F

更新日期：1998-08-01 00:00:00

abstract：:The MA-10 mouse Leydig tumor cell line produces large amounts of steroids only in response to hormonal stimulation while the R2C rat Leydig tumor cell line is constitutively steroidogenic in nature. In an effort to uncover the potential reasons for constitutive steroidogenesis in R2C cells, we have recently shown that...

journal_title：Endocrine research

authors： Rao RM,Jo Y,Babb-Tarbox M,Syapin PJ,Stocco DM

更新日期：2002-11-01 00:00:00

abstract：:Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...

journal_title：Endocrine research

authors： Pon LA,Epstein LF,Orme-Johnson NR

更新日期：1986-01-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：:A method is described for the preparation of high yields of viable, dissociated cells from porcine theca interna and corpus luteum and from human and bovine endometrium. The tissues were dissociated by incubation at 37 degrees C in a mixture of 0.5% collagenase, 0.1% hyaluronidase and 0.1% pronase in balanced salt sol...

journal_title：Endocrine research

authors： Marcus GJ,Connor L,Domingo MT,Tsang BK,Downey BR,Ainsworth L

更新日期：1984-01-01 00:00:00

abstract：:Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...

journal_title：Endocrine research

authors： Forti FL,Armelin HA

更新日期：2000-11-01 00:00:00

abstract：:The steady state level of most cellular phosphoproteins is dependent on the relative catalytic activities of intracellular protein kinases and phosphatases. In adrenal cortex, ACTH acts through PKA activation and Ser/Tre phosphorylation. Phosphatases involved in this pathway are not completely described, particularly ...

journal_title：Endocrine research

authors： Cornejo Maciel F,Paz C,Neuman MI,Podestá EJ

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects. MATERIALS AND METHOD:The study population was represente...

journal_title：Endocrine research

authors： Lippi G,Danese E,Montagnana M,Nouvenne A,Meschi T,Borghi L

更新日期：2015-01-01 00:00:00

abstract：:The B vitamin nicotinamide (NIC), commonly known as niacin, is currently in trial as a potential means of preventing Type 1 diabetes in first-degree relatives of affected individuals. Sodium butyrate (BUT) a common dietary micronutrient has also been reported to have beneficial effects on the differentiation and funct...

journal_title：Endocrine research

authors： Liu HK,Green BD,Flatt PR,McClenaghan NH,McCluskey JT

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS:The study consisted of 52 newly treate...

journal_title：Endocrine research

authors： Ohishi T,Fujita T,Suzuki D,Nishida T,Yamamoto K,Okabayashi R,Ushirozako H,Banno T,Matsuyama Y

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the expression of the glucose transporters GLUT1 and GLUT3 in papillary thyroid carcinomas (PTCs) and to elucidate their relationship with the BRAF V600E mutation and F-18 FDG uptake. MATERIALS AND METHODS:We retrospectively analyzed data of 52 PTC patients (41 women a...

journal_title：Endocrine research

authors： Yoon M,Jung SJ,Kim TH,Ha TK,Urm SH,Park JS,Lee SM,Bae SK

更新日期：2016-01-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:It has been suggested that the changes in hormone levels that occur with menopause and aging are related to loss of muscle mass. However, the role of gonadotropins in this process is unknown. OBJECTIVES:To analyze the relationship between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and l...

journal_title：Endocrine research

authors： García-Martín A,Reyes-García R,García-Castro JM,Muñoz-Garach A,Escobar-Jiménez F,Muñoz-Torres M

更新日期：2013-08-01 00:00:00

abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase plays a crucial role in the steroidogenic process in the adrenal gland. In the present study we tried to characterize its localization and developmental changes in the rat adrenal cortex during the postnatal period, using immunohistochemical methods. The development of the...

journal_title：Endocrine research

authors： Pignatelli D,Bento MJ,Maia M,Magalhães MM,Magalhães MC,Mason JI

更新日期：1999-02-01 00:00:00

abstract：:We established cell lines from adrenal tumors of transgenic mice harboring the large T-antigen of simian virus 40 under the control of the adrenocortical specific promoter of the scavenger aldose reductase-like akr1b7 gene. Mass spectrometry analyses of serum-supplemented or serum-free culture media showed that ATC1 l...

journal_title：Endocrine research

authors： Ragazzon B,Lefrançois-Martinez AM,Val P,Tournaire C,Berger M,Gachancard-Bouya JL,Bègue RJ,Veyssière G,Martinez A

更新日期：2004-11-01 00:00:00

abstract：:TRH is negatively regulated by T3 both in the hypothalamic paraventricular nucleus and transient transfection models. Mutations in hTR beta 1 genes are associated with the syndrome of generalized resistance to thyroid hormone. To investigate potential effects of mutant TRs on T3 regulation of the hTRH gene, transient ...

journal_title：Endocrine research

authors： Li QL,Feng P,Satoh T,Shi ZX,Wang R,Weintraub BD,Wilber JF

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a cri...

journal_title：Endocrine research

authors： Karakose M,Caliskan M,Arslan MS,Demirci T,Karakose S,Tutal E,Cakal E

更新日期：2018-02-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...

journal_title：Endocrine research

authors： Miller HA 3rd,Southerland CM

更新日期：1990-01-01 00:00:00

abstract：:Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...

journal_title：Endocrine research

authors： Stevic MS,Stefanic M,Tokic S,Glavas-Obrovac L,Mihaljevic S,Karner I

更新日期：2014-01-01 00:00:00