Role of phosphorylation, gene dosage and Dax-1 in SF-1 mediated steroidogenesis.

abstract：INTRODUCTION:Impairments in neuroendocrine regulation of food intake and postprandial satiety are leading causes to obesity. Ghrelin peptide is a GI hormone known to increase food intake partly through induction of growth hormone. The regulation of ghrelin production is still unknown. OBJECTIVE:The aim of the current ...

journal_title：Endocrine research

authors： Haddad H,Mroueh M,Faour WH,Daher C

更新日期：2014-01-01 00:00:00

abstract：:Immunohistochemistry using a StAR peptide antiserum had previously revealed strong staining in rat and bovine adrenal medulla, suggesting the presence of a protein immunogenically related to StAR. Western blots of bovine medulla tissue homogenates showed the principal adrenal medullary immuno-reactive species to have ...

journal_title：Endocrine research

authors： Lo YC,MacKenzie SM,Howie AF,Apps DK,Mason JI,Williams BC,Morley SD

更新日期：2000-11-01 00:00:00

abstract：:The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor. For estrogen receptor, proteasome inhibition decreases ligand-mediated transcription. We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in...

journal_title：Endocrine research

authors： Yokota K,Shibata H,Kobayashi S,Suda N,Murai A,Kurihara I,Saito I,Saruta T

更新日期：2004-11-01 00:00:00

abstract：:The MA-10 mouse Leydig tumor cell line produces large amounts of steroids only in response to hormonal stimulation while the R2C rat Leydig tumor cell line is constitutively steroidogenic in nature. In an effort to uncover the potential reasons for constitutive steroidogenesis in R2C cells, we have recently shown that...

journal_title：Endocrine research

authors： Rao RM,Jo Y,Babb-Tarbox M,Syapin PJ,Stocco DM

更新日期：2002-11-01 00:00:00

abstract：:Recent evidence supports the hypothesis that sympathetic neurons play a significant role in the regulation of adrenocortical cell proliferation and steroidogenesis. Co-cultures of rat adrenocortical and sympathetic ganglion cells have been established to study sympatho-adrenal interactions. In these studies we have co...

journal_title：Endocrine research

authors： Wu CH,Holzwarth MA

更新日期：1996-11-01 00:00:00

abstract：:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...

journal_title：Endocrine research

authors： Bokov AF,Ko D,Richardson A

更新日期：2009-01-01 00:00:00

abstract：:Islets derived from patients with persistent hyperinsulinemic hypoglycemia of infancy, PHHI, show a significant capacity to proliferate in vitro without the addition of growth factors. However, as with other differentiated cells, PHHI-derived islet cells show a loss of differentiated function with repeated subculture....

journal_title：Endocrine research

authors： Webb M,James RF

更新日期：2005-01-01 00:00:00

abstract：:Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...

journal_title：Endocrine research

authors： Daussac A,Barat P,Servant N,Yacoub M,Missonier S,Lavran F,Gaspari L,Sultan C,Paris F

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastograph...

journal_title：Endocrine research

authors： Mansor M,Okasha H,Esmat S,Hashem AM,Attia KA,El-din Hussein H

更新日期：2012-01-01 00:00:00

abstract：:The B vitamin nicotinamide (NIC), commonly known as niacin, is currently in trial as a potential means of preventing Type 1 diabetes in first-degree relatives of affected individuals. Sodium butyrate (BUT) a common dietary micronutrient has also been reported to have beneficial effects on the differentiation and funct...

journal_title：Endocrine research

authors： Liu HK,Green BD,Flatt PR,McClenaghan NH,McCluskey JT

更新日期：2004-02-01 00:00:00

abstract：:The secretory activity of the adrenal gland is mainly regulated by peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now increasing evidence that local factors, including neuropeptides and neurotransmitters, can also participate in the control of adrenocortical cells. In particular, serotonin (5-...

journal_title：Endocrine research

authors： Delarue C,Contesse V,Lefebvre H,Lenglet S,Grumolato L,Kuhn JM,Vaudry H

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:It has been suggested that the changes in hormone levels that occur with menopause and aging are related to loss of muscle mass. However, the role of gonadotropins in this process is unknown. OBJECTIVES:To analyze the relationship between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and l...

journal_title：Endocrine research

authors： García-Martín A,Reyes-García R,García-Castro JM,Muñoz-Garach A,Escobar-Jiménez F,Muñoz-Torres M

更新日期：2013-08-01 00:00:00

abstract：:The recent cloning of a family of melanocortin receptors (MC-R) has identified five distinct G protein- and adenylate cyclase-coupled receptors. The MC2-receptor (MC2-R) preferentially binds ACTH. It is expressed in the adrenal cortex and is hence considered to be the ACTH receptor. The MC5-receptor (MC5-R) binds ACTH...

journal_title：Endocrine research

authors： Liakos P,Chambaz EM,Feige JJ,Defaye G

更新日期：1998-08-01 00:00:00

abstract：:Maternal smoking is considered to be a risk factor for low birth weight. It is hypothesized that alteration in leptin concentration may be associated with reduced fetal growth. In this study, we assess the effect of smoking during pregnancy on maternal and neonatal serum leptin concentrations, and also on breast milk ...

journal_title：Endocrine research

authors： Ozkan B,Ermis B,Tastekin A,Doneray H,Yildirim A,Ors R

更新日期：2005-01-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects. MATERIALS AND METHOD:The study population was represente...

journal_title：Endocrine research

authors： Lippi G,Danese E,Montagnana M,Nouvenne A,Meschi T,Borghi L

更新日期：2015-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...

journal_title：Endocrine research

authors： Miller HA 3rd,Southerland CM

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...

journal_title：Endocrine research

authors： Karbownik M,Zasada K,Wyczechowska D,Lewiński A,Fabianowska-Majewska K

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) are common medications in Chinese patients with hyperthyroidism and PTU-induced antineutrophil cytoplasmic antibody (ANCA) positive vasculitis has been reported. The current cross-sectional study aimed to investigate the prevalence and the...

journal_title：Endocrine research

authors： Gao Y,Zhao MH,Guo XH,Xin G,Gao Y,Wang HY

更新日期：2004-05-01 00:00:00

abstract：:Activation of calcium-activated, phospholipid-dependent protein kinase C by phorbol esters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) has been shown to mediate release of hormones in many systems. To investigate the role of protein kinase C in the mechanism of pituitary ACTH release, we studied the effect of ...

journal_title：Endocrine research

authors： Sobel DO

更新日期：1988-01-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a ...

journal_title：Endocrine research

authors： Shimojo M,Condon J,Whorwood CB,Stewart PM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. OBJECTIVES:Th...

journal_title：Endocrine research

authors： Trevizam PG,Tagliarini JV,Castilho EC,de Alencar Marques M,Kiy Y,Mazeto GMFS

更新日期：2017-02-01 00:00:00

abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...

journal_title：Endocrine research

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1994-05-01 00:00:00

abstract：:The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...

journal_title：Endocrine research

authors： Keramidas M,Feige JJ,Thomas M

更新日期：2004-11-01 00:00:00

abstract：:The action of peptide hormones from the anterior pituitary regulates transcription of a large number of genes located in most, if not all, tissues. This action is mediated through regulation of steroid hormone production in the steroidogenic factories (adrenals, gonads). These steroid hormones are transported through ...

journal_title：Endocrine research

authors： Waterman MR,Bischof LJ

更新日期：1996-11-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：:We studied whether the activation of rat brown adipose tissue (BAT) by cold exposure or by the administration of beta-3-noradrenergic agonist CGP-12177 could be prevented by the inhibition of thyroxine (T4) to triiodothyronine (T3) conversion. Hypothyroid rats were treated with replacement doses of T4, T4 plus iopanoi...

journal_title：Endocrine research

authors： Zaninovich AA,Rebagliati I,Raíces M,Ricci C,Hagmüller K

更新日期：2000-05-01 00:00:00

abstract：:We have recently reported on the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK) and carbonic anhydrase I (CA-I) and II (CA-II) isoenzymes obtained from erythrocytes of healthy subjects and untreated patients with hyperthyroid diseases. Also, erythrocyte zinc concentrations were measured. Red b...

journal_title：Endocrine research

authors： Odçikin E,Ozdemir H,Ciftçi M,Capoğlu I

更新日期：2002-02-01 00:00:00

abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...

journal_title：Endocrine research

authors： Wynn J,Shah U,Murray SA

更新日期：2002-11-01 00:00:00

abstract：:Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...

journal_title：Endocrine research

authors： Al-Ansari F,Lahooti H,Stokes L,Edirimanne S,Wall J

更新日期：2018-11-01 00:00:00