Abstract：
:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antioxidant because it was administered at very high dosages. Therefore, we have identified a low yet physiologically effective dose of E2. We then administered this dose using subcutaneous time-release pellets to ovariectomized mice. Two weeks after E2 pellet implantation, sham-operated, ovariectomized, and ovariectomized E2-supplemented female mice were injected with a lethal dose of paraquat and their survival was followed. It was observed that ovariectomy exacerbates paraquat-induced mortality and is rescued by E2 supplementation. An equivalent experiment was performed on sham-operated, orchidectomized, and E2-supplemented orchidectomized male mice. The survival of male mice was improved by orchidectomy, and E2 gave no further benefit. We interpret the results to mean that E2 is protective against oxidative stress through its regulatory role and that testosterone diminishes protection against oxidative stress.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Bokov AF,Ko D,Richardson Adoi
10.1080/07435800902913600subject
Has Abstractpub_date
2009-01-01 00:00:00pages
43-58issue
1-2eissn
0743-5800issn
1532-4206pii
910860504journal_volume
34pub_type
杂志文章abstract：:An analysis of the glucocorticoid receptor population of skeletal muscle and liver from dystrophic and control mice was performed. These data demonstrate that the cytosol of muscles from dystrophic animals contain a significantly higher concentration of glucocorticoid receptors (approximately 100%) relative to the cyt...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435808409046761
更新日期：1984-01-01 00:00:00
abstract：:The purpose of this study was to examine the effects of exercise on anterior pituitary hormones (adrenocorticotropic hormone (ACTH), leutinizing hormone (LH) and growth hormone) as well as on cortisol at low altitude (350 meters below the sea level) and to compare these effects with those at a moderate level altitude ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809609030513
更新日期：1996-08-01 00:00:00
abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120015059
更新日期：2002-08-01 00:00:00
abstract：:Combined partial deficiency of 17alpha-hydroxylase and 21-hydroxylase activities was first described in 1985; however the genes for P450c17 and P450c21 in these patients lack mutations. In 1986 we postulated that this disorder might be due to mutations in P450 oxidoreductase (POR), the flavoprotein that donates electr...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-200044134
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2014.913614
更新日期：2015-01-01 00:00:00
abstract：AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2016.1155597
更新日期：2017-02-01 00:00:00
abstract：:Diabetes mellitus impairs ventricular function, which itself may be disparately influenced by gender. This study compared the impact of gender on cardiac contractile response in ventricular myocytes from wild-type FVB and calmodulin-induced diabetic transgenic (OVE26) mice at young (2 month) and older (11 month) age. ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120022318
更新日期：2003-05-01 00:00:00
abstract：:Maternal smoking is considered to be a risk factor for low birth weight. It is hypothesized that alteration in leptin concentration may be associated with reduced fetal growth. In this study, we assess the effect of smoking during pregnancy on maternal and neonatal serum leptin concentrations, and also on breast milk ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800500371748
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. OBJECTIVE:The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpubli...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.3109/07435800.2013.778865
更新日期：2013-01-01 00:00:00
abstract：:In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809409030414
更新日期：1994-11-01 00:00:00
abstract：:In a previous study we demonstrated a significant increase of CD5+ B subset in patients with Graves' disease (GD) compared with normal controls. The aim of this study was to compare the percentage of CD5+ B and CD5- B cells in GD with that in different forms of autoimmune and non immune-mediated thyroid diseases. Seve...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809709031844
更新日期：1997-02-01 00:00:00
abstract：:The action of peptide hormones from the anterior pituitary regulates transcription of a large number of genes located in most, if not all, tissues. This action is mediated through regulation of steroid hormone production in the steroidogenic factories (adrenals, gonads). These steroid hormones are transported through ...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.1080/07435809609043755
更新日期：1996-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes in the elderly people. Previous studies have reported the sex differences in risk for type 2 diabetes, especially in the elderly people, whereas reasons for these sex differences remain poorly understood...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2015.1124437
更新日期：2016-08-01 00:00:00
abstract：:The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120016801
更新日期：2002-11-01 00:00:00
abstract：:Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809309035409
更新日期：1993-03-01 00:00:00
abstract：:Two distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) with respect to enzymatic activity were identified in the ovine liver and kidney. 11 beta-HSD1 (the hepatic isoform) was reversible and NADP(H)-dependent. By contrast, 11 beta-HSD2 (the renal isoform) was unidirectional and NAD-dependent. Ovin...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.3109/07435809509030453
更新日期：1995-02-01 00:00:00
abstract：:Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800.2018.1470639
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. OBJECTIVES:Th...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2016.1173056
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To determine whether daily oral micronized progesterone affects bone turnover, as estimated by serum and urine biochemical markers, in postmenopausal women on long-term estrogen replacement therapy (ERT). METHODS:We recruited 14 women aged 65 or older to participate in a 9-week trial with micronized progestero...
journal_title：Endocrine research
pub_type： 临床试验,杂志文章
doi：10.1081/erc-120022294
更新日期：2003-05-01 00:00:00
abstract：:Purpose: Limited and contradictory data on the circulating levels of glucagon-like peptide (GLP-1) and resistin in hepatitis C virus genotype-4 (HCV-4) cirrhotic patients are present. Thus, this study aimed to evaluate their concentrations and to investigate the association between total GLP-1, resistin, and insulin r...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800.2019.1627551
更新日期：2020-02-01 00:00:00
abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase plays a crucial role in the steroidogenic process in the adrenal gland. In the present study we tried to characterize its localization and developmental changes in the rat adrenal cortex during the postnatal period, using immunohistochemical methods. The development of the...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809909066126
更新日期：1999-02-01 00:00:00
abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809609043775
更新日期：1996-11-01 00:00:00
abstract：:Comparison of binding of 125I-porcine FSH to porcine granulosa cells from small and large ovarian follicles indicated that binding is dependent on both time and temperature. At 37 C, binding of ligand is more than four times higher in cells from small follicles than in cells from large follicles within 30 minutes of t...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809409035857
更新日期：1994-02-01 00:00:00
abstract：:The enzyme, 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase (3 beta-HSD) is an essential element in the biosynthetic pathway for potent adrenal steroid hormones that appear to regulate maturation of many tissues in utero and are critical for homeostasis after birth. The results of prior studies are suggestive ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809509030422
更新日期：1995-02-01 00:00:00
abstract：:The presence of vasoactive intestinal peptide and neuropeptide Y in thyroid nerves and their effects on thyroid blood flow are well known. However, the effects of these two neuropeptides on the various processes involved in thyroid hormone biosynthesis and release have not been fully explored. We have now tested these...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809209026678
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:Antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) are common medications in Chinese patients with hyperthyroidism and PTU-induced antineutrophil cytoplasmic antibody (ANCA) positive vasculitis has been reported. The current cross-sectional study aimed to investigate the prevalence and the...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120037729
更新日期：2004-05-01 00:00:00
abstract：:The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809809032700
更新日期：1998-08-01 00:00:00
abstract：:Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809509030493
更新日期：1995-11-01 00:00:00
abstract：:Neutrophils have an important role in the host defense. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. The causes of these impairments are not clear. We aimed to investigate changes of peripheral neutrophil counts and functions and their relatio...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809909066155
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2012.745128
更新日期：2013-08-01 00:00:00
