Regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of the cholesterol transfer proteins StAR and PBR.

abstract：:CYP17 is not expressed in adult mouse adrenal glands but is expressed in a subset of fetal adrenocortical cells, indicating the potential to produce both corticosterone and cortisol during murine embryogenesis. CYP11A is expressed in the fetal adrenal but also in developing hindgut, which will form the colon, and in c...

journal_title：Endocrine research

authors： Keeney DS

更新日期：1995-02-01 00:00:00

abstract：:The effect of crowding on the pituitary-gonadal axis was studied in adult male rats. Crowding reduced body weight gain, did not alter relative adrenal weight and increased relative testis weight. Neither basal levels of corticosterone nor its response to acute stress were altered by crowding. Likewise, LH secretion wa...

journal_title：Endocrine research

authors： Armario A,Lopez-Calderón A

更新日期：1986-01-01 00:00:00

abstract：AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...

journal_title：Endocrine research

authors： Simental-Mendía LE,Simental-Mendía E,Rodríguez-Morán M,Guerrero-Romero F

更新日期：2017-02-01 00:00:00

abstract：:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...

journal_title：Endocrine research

authors： Bokov AF,Ko D,Richardson A

更新日期：2009-01-01 00:00:00

abstract：:The prostate gland of humans and other animals has the unique function of accumulating and secreting extraordinarily high levels of citrate. The prostate secretory epithelial cells synthesize citrate which, due to a limiting mitochondrial (m-) aconitase, accumulates rather than being oxidized. Thus citrate is essentia...

journal_title：Endocrine research

authors： Costello LC,Liu Y,Zou J,Franklin RB

更新日期：2000-02-01 00:00:00

abstract：:Two CYP21 genes, the active CYP21 and the pseudogene, CYP21P, also pairs of duplicated genes including the XA, XB, XB-S; YA, YB; and ZA, ZB are arranged in tandem next to the serum complement C4 genes (C4A and C4B). In this report, we have analyzed the influence of some DNA sequences within the C4A/CYP21P region on th...

journal_title：Endocrine research

authors： Chang SF,Cheng CL

更新日期：1998-08-01 00:00:00

abstract：:There are two main regulatory sites of aldosterone biosynthesis, the early rate-limiting step by the P450scc and the final steps by the P450aldo. We have already demonstrated that, during gestation, activity and mRNA levels of P450aldo are increased. It has been shown that changes in sodium and potassium in the diet m...

journal_title：Endocrine research

authors： Brochu M,Roy-Clavel E,Picard S,St-Louis J

更新日期：1998-08-01 00:00:00

abstract：:A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea ...

journal_title：Endocrine research

authors： Bani Hani I,El-Migdadi F,Shotar A,Abudheese R,Bashir N

更新日期：2001-02-01 00:00:00

abstract：:The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...

journal_title：Endocrine research

authors： Pignatelli D,Leitão D,Maia M,Schmidt F

更新日期：1998-08-01 00:00:00

abstract：:Several lines of evidence have suggested that the nuclear receptor Steroidogenic Factor-1 (SF-1 or Ad4BP) may be directly involved in the cAMP-dependent regulation of steroid hydroxylase genes in adrenocortical cells. In the bovine CYP17 gene, which encodes the cytochrome P450 17alpha-hydroxylase, an SF-1 site is pres...

journal_title：Endocrine research

authors： Lund J,Jacob A,Aesöy R,Yri OE,Mellgren G

更新日期：1998-08-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a ...

journal_title：Endocrine research

authors： Shimojo M,Condon J,Whorwood CB,Stewart PM

更新日期：1996-11-01 00:00:00

abstract：:We quantitated serial serum beta-hydroxybutyrate (beta-OHB) levels using the Ketosite method in 9 children with IDDM who were treated for diabetic ketoacidosis (DKA) and compared them to urinary ketone measurements by dipstick. Persistent elevations of serum beta-OHB were seen in six patients when the urine became cle...

journal_title：Endocrine research

authors： Nadgir UM,Silver FL,MacGillivray MH

更新日期：2001-02-01 00:00:00

abstract：:Cerebrovascular accidents are one of the life-threatening complications of diabetic ketoacidosis (DKA) in children and adolescents. Our objective was to evaluate the effect of DKA and its treatment on factors known to affect thrombotic activity (protein C; protein S; von Willebrand factor, fibrinogen; homocysteine; an...

journal_title：Endocrine research

authors： Carl GF,Hoffman WH,Passmore GG,Truemper EJ,Lightsey AL,Cornwell PE,Jonah MH

更新日期：2003-02-01 00:00:00

abstract：:The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in...

journal_title：Endocrine research

authors： Bicknell AB

更新日期：2002-11-01 00:00:00

abstract：:Using Western blot analysis we found transcriptional co-repressor Sin3A to be expressed at a higher level in male mouse kidney than in females. HDAC1 (histone deacetylase 1) protein, another co-repressor forming complexes with Sin3A, was not higher in males. No sex differences in Sin3A expression were found after gona...

journal_title：Endocrine research

authors： Xu J,Arnold AP

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Adiponectin and chemerin have been reported their associations with insulin resistance and chronic inflammation. However, the relationship between adiponectin and chemerin themselves has not been fully elucidated. Therefore, we investigated the effects of changes in adiponectin and chemerin levels after a weigh...

journal_title：Endocrine research

authors： Shin HY,Park S,Lee JW

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:The diagnosis and management of osteoporosis and osteoporotic fractures are challenging in rural and underdeveloped areas of China because medical resources are inaccessible; thus, a simple and accurate method is essential for the detection of vertebral fractures. We aimed to examine the relationship between...

journal_title：Endocrine research

authors： Chen R,Liu S,Huang M,Ou Y,Liu W,Cui R,Yuan L,Xie Z,Sheng Z,Liu H

更新日期：2021-02-01 00:00:00

abstract：:Progesterone (P) given intramuscularly increases renal sodium excretion. We tested the in vitro capacity of P to bind to the human mineralocorticoid receptor (MR) with a reticulocyte lysate system and Ps transactivation potency in transfected CV-1 cells. Progesterone binds with higher affinity to the MR than aldostero...

journal_title：Endocrine research

authors： Quinkler M,Diederich S

更新日期：2002-11-01 00:00:00

abstract：AIM:To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D). MATERIALS AND METHODS:Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked...

journal_title：Endocrine research

authors： Sakly W,Mankaï A,Achour A,Thabet Y,Ouertani M,Boughammoura L,Harbi A,Chaieb L,Sfar MT,Ghedira I

更新日期：2012-01-01 00:00:00

abstract：:Hippocampal functions are influenced by steroid hormones, such as testosterone and estradiol. It has been demonstrated that hippocampus-derived steroid hormones play important roles in neuronal protection and synapse formation. Our research groups have demonstrated that estradiol is de novo synthesized in the rat hipp...

journal_title：Endocrine research

authors： Munetsuna E,Hattori M,Yamazaki T

更新日期：2014-01-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...

journal_title：Endocrine research

authors： Wynn J,Shah U,Murray SA

更新日期：2002-11-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is the most frequent cause of congenital adrenal hyperplasia, an inherited inability to synthesize cortisol. Mutations causing this disorder have been characterized by hybridization analysis of patient DNA samples using cDNA and oligonucleotide probes, and by cloning and sequencing of...

journal_title：Endocrine research

authors： White PC

更新日期：1989-01-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...

journal_title：Endocrine research

authors： Karbownik M,Zasada K,Wyczechowska D,Lewiński A,Fabianowska-Majewska K

更新日期：2002-08-01 00:00:00

abstract：:In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...

journal_title：Endocrine research

authors： Bieńkiewicz A,Pajszczyk-Kieszkiewicz T,Kuś E,Dabrowski R

更新日期：1994-11-01 00:00:00

abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...

journal_title：Endocrine research

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. OBJECTIVE:The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpubli...

journal_title：Endocrine research

authors： Davis PJ,Glinsky GV,Lin HY,Incerpi S,Davis FB,Mousa SA,Tang HY,Hercbergs A,Luidens MK

更新日期：2013-01-01 00:00:00

abstract：:The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein...

journal_title：Endocrine research

authors： Raza FS,Puddefoot JR,Vinson GP

更新日期：1998-08-01 00:00:00

abstract：:Type 1 angiotensin II (AII) receptors (AT1 receptors), besides stimulation of aldosterone secretion, seem to transduce the growth factor-like activity of AII on glomerulosa cells. Although a local renin-angiotensin system and AII synthesis have been found in human adrenals and aldosteronomas, it is unclear whether ald...

journal_title：Endocrine research

authors： Sarzani R,Opocher G,Dessì-Fulgheri P,Paci V,Cola G,Rocco S,Vianello B,Mantero F,Rappelli A

更新日期：1995-02-01 00:00:00