Acute effects of recombinant murine leptin on rat pituitary-adrenocortical function.

abstract：:TRH is negatively regulated by T3 both in the hypothalamic paraventricular nucleus and transient transfection models. Mutations in hTR beta 1 genes are associated with the syndrome of generalized resistance to thyroid hormone. To investigate potential effects of mutant TRs on T3 regulation of the hTRH gene, transient ...

journal_title：Endocrine research

authors： Li QL,Feng P,Satoh T,Shi ZX,Wang R,Weintraub BD,Wilber JF

更新日期：1997-11-01 00:00:00

abstract：:In the guinea pig adrenal the cells of the outer zone secrete high levels of steroid and respond to ACTH with increased synthesis of cholesterol and steroid. The outer zone consists of two cell types: zona fasciculata (ZF) and zona glomerulosa (ZG). To determine the relative contribution of ZF and ZG to the outer zone...

journal_title：Endocrine research

authors： Brody RI,Black VH

更新日期：1991-01-01 00:00:00

abstract：:Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...

journal_title：Endocrine research

authors： Arlt W,Callies F,Allolio B

更新日期：2000-11-01 00:00:00

abstract：:The zonal distribution of aldosterone synthase cytochrome P450 (P450aldo) in the adrenal cortex of male hamsters was investigated by immunofluorescence and electron microscopy, using an anti-P450aldo peptide antibody. On cryostat sections the immunolocalization of P450aldo was confined to the zona glomerulosa cells. O...

journal_title：Endocrine research

authors： LeHoux JG,Martel D,LeHoux J,Ducharme L,Lefebvre A,Brière N

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...

journal_title：Endocrine research

authors： Kutoh E,Hori T

更新日期：2013-08-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：UNLABELLED:Absract Purpose: Mutations in the TPO gene have been reported to cause congenital hypothyroidism (CH), and our aim in this study was to determine the genetic basis of congenital hypothyroidism in two affected children coming from a consanguineous family. METHODS:Since CH is usually inherited in autosomal re...

journal_title：Endocrine research

authors： Cangul H,Darendeliler F,Saglam Y,Kucukemre B,Kendall M,Boelaert K,Barrett TG,Maher ER

更新日期：2015-01-01 00:00:00

abstract：:Several lines of evidence have suggested that the nuclear receptor Steroidogenic Factor-1 (SF-1 or Ad4BP) may be directly involved in the cAMP-dependent regulation of steroid hydroxylase genes in adrenocortical cells. In the bovine CYP17 gene, which encodes the cytochrome P450 17alpha-hydroxylase, an SF-1 site is pres...

journal_title：Endocrine research

authors： Lund J,Jacob A,Aesöy R,Yri OE,Mellgren G

更新日期：1998-08-01 00:00:00

abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...

journal_title：Endocrine research

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) are common medications in Chinese patients with hyperthyroidism and PTU-induced antineutrophil cytoplasmic antibody (ANCA) positive vasculitis has been reported. The current cross-sectional study aimed to investigate the prevalence and the...

journal_title：Endocrine research

authors： Gao Y,Zhao MH,Guo XH,Xin G,Gao Y,Wang HY

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether 25-hydroxyvitamin D [25(OH)D] can mediate effects without being converted to 1α,25-dihydroxyvitamin D [1,25(OH)2D]. METHODS:Vitamin D3 (VD3) was injected intramuscularly to 25-hydroxyvitamin D-1α-hydroxylase [1α(OH)ase] gene knockout (KO) male mice with a dose of 10,000 IU per week for...

journal_title：Endocrine research

authors： Zhang ZL,Ding XF,Tong J,Li BY

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of exercise on anterior pituitary hormones (adrenocorticotropic hormone (ACTH), leutinizing hormone (LH) and growth hormone) as well as on cortisol at low altitude (350 meters below the sea level) and to compare these effects with those at a moderate level altitude ...

journal_title：Endocrine research

authors： Bashir N,el-Migdadi F,Hasan Z,al-Hader AA,Wezermes I,Gharaibeh M

更新日期：1996-08-01 00:00:00

abstract：:Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...

journal_title：Endocrine research

authors： Forti FL,Armelin HA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determin...

journal_title：Endocrine research

authors： Calan M,Kume T,Yilmaz O,Arkan T,Kocabas GU,Dokuzlar O,Aygün K,Oktan MA,Danıs N,Temur M

更新日期：2016-08-01 00:00:00

abstract：:Neutrophils have an important role in the host defense. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. The causes of these impairments are not clear. We aimed to investigate changes of peripheral neutrophil counts and functions and their relatio...

journal_title：Endocrine research

authors： Cantürk Z,Cantürk NZ,Cetinarslan B,Erçin C,Dökmetaş S,Sencan M

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications ...

journal_title：Endocrine research

authors： Esteghamati A,Asnafi S,Eslamian M,Noshad S,Nakhjavani M

更新日期：2015-01-01 00:00:00

abstract：:There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement th...

journal_title：Endocrine research

authors： Onobrakpeya OA,Fall PM,Willard A,Chakravarthi P,Hansen A,Raisz LG

更新日期：2001-11-01 00:00:00

abstract：:Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...

journal_title：Endocrine research

authors： Stevic MS,Stefanic M,Tokic S,Glavas-Obrovac L,Mihaljevic S,Karner I

更新日期：2014-01-01 00:00:00

abstract：:The rat adrenal cortex possesses at least two mechanisms for uptake of extracellular lipoprotein cholesterol; one is receptor mediated endocytosis and the second is a non-endocytotic pathway. The latter was revealed by the ability of lipoproteins such as HDL which do not possess apo B or apo E to enhance steroid hormo...

journal_title：Endocrine research

authors： Gwynne JT,Hess B,Hughes T,Rountree R,Mahaffee D

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects. MATERIALS AND METHOD:The study population was represente...

journal_title：Endocrine research

authors： Lippi G,Danese E,Montagnana M,Nouvenne A,Meschi T,Borghi L

更新日期：2015-01-01 00:00:00

abstract：:In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...

journal_title：Endocrine research

authors： White PC,Hautanen A,Kupari M

更新日期：1998-08-01 00:00:00

abstract：:Excessive aldosterone secretion in some hypertensive patients may result from abnormal aldosterone synthase (AS) gene regulation in response to changes in dietary sodium intake. We have utilized NCI-H295 cells, which exhibit stable angiotensin-induced aldosterone secretion, for transient transfections with murine AS/h...

journal_title：Endocrine research

authors： Holland OB,Carr B,Brasier AR

更新日期：1995-02-01 00:00:00

abstract：:The objective of the current investigation was to study adrenomedullary and glycemic responses to stress in soft-shelled turtles, Lissemys p. punctata. Dehydration (7 days) and formalin (formaldehyde 1%, 0.1 mL/100 g body wt. daily for 7 days) stress-stimulated adrenomedullary activity at histological (by increasing t...

journal_title：Endocrine research

authors： Ray PP,Sarkar S,Chaudhuri-Sengupta S,Maiti BR

更新日期：2008-01-01 00:00:00

abstract：:Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects a...

journal_title：Endocrine research

authors： Agarwal AK

更新日期：2003-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：:Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cell...

journal_title：Endocrine research

authors： Swart AC,Brown N,Kolar N,Swart P

更新日期：2000-11-01 00:00:00

abstract：:The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor. For estrogen receptor, proteasome inhibition decreases ligand-mediated transcription. We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in...

journal_title：Endocrine research

authors： Yokota K,Shibata H,Kobayashi S,Suda N,Murai A,Kurihara I,Saito I,Saruta T

更新日期：2004-11-01 00:00:00

abstract：:Hippocampal functions are influenced by steroid hormones, such as testosterone and estradiol. It has been demonstrated that hippocampus-derived steroid hormones play important roles in neuronal protection and synapse formation. Our research groups have demonstrated that estradiol is de novo synthesized in the rat hipp...

journal_title：Endocrine research

authors： Munetsuna E,Hattori M,Yamazaki T

更新日期：2014-01-01 00:00:00

abstract：:There are two main regulatory sites of aldosterone biosynthesis, the early rate-limiting step by the P450scc and the final steps by the P450aldo. We have already demonstrated that, during gestation, activity and mRNA levels of P450aldo are increased. It has been shown that changes in sodium and potassium in the diet m...

journal_title：Endocrine research

authors： Brochu M,Roy-Clavel E,Picard S,St-Louis J

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS:The study consisted of 52 newly treate...

journal_title：Endocrine research

authors： Ohishi T,Fujita T,Suzuki D,Nishida T,Yamamoto K,Okabayashi R,Ushirozako H,Banno T,Matsuyama Y

更新日期：2017-08-01 00:00:00