Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.

abstract：:Excessive aldosterone secretion in some hypertensive patients may result from abnormal aldosterone synthase (AS) gene regulation in response to changes in dietary sodium intake. We have utilized NCI-H295 cells, which exhibit stable angiotensin-induced aldosterone secretion, for transient transfections with murine AS/h...

journal_title：Endocrine research

authors： Holland OB,Carr B,Brasier AR

更新日期：1995-02-01 00:00:00

abstract：:Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secre...

journal_title：Endocrine research

authors： Mathieu MN,Hamroun D,Pouzeratte Y,Guérineau NC,Guillon G,Chevillard C

更新日期：1998-08-01 00:00:00

abstract：:Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...

journal_title：Endocrine research

authors： Forti FL,Armelin HA

更新日期：2000-11-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：INTRODUCTION:Impairments in neuroendocrine regulation of food intake and postprandial satiety are leading causes to obesity. Ghrelin peptide is a GI hormone known to increase food intake partly through induction of growth hormone. The regulation of ghrelin production is still unknown. OBJECTIVE:The aim of the current ...

journal_title：Endocrine research

authors： Haddad H,Mroueh M,Faour WH,Daher C

更新日期：2014-01-01 00:00:00

abstract：:The effects of forskolin on the regulation of steroidogenesis and growth were examined in the Y1 adrenocortical tumor cell line, and the roles of cAMP and cAMP-dependent protein kinase in these actions of forskolin were evaluated. Forskolin, like corticotropin, stimulated steroidogenesis 3-fold and inhibited growth by...

journal_title：Endocrine research

authors： Schimmer BP,Schulz P

更新日期：1985-01-01 00:00:00

abstract：:Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by th...

journal_title：Endocrine research

authors： Passaro EA,Meltzer HY,Gudelsky GA

更新日期：1987-01-01 00:00:00

abstract：:Immunohistochemistry using a StAR peptide antiserum had previously revealed strong staining in rat and bovine adrenal medulla, suggesting the presence of a protein immunogenically related to StAR. Western blots of bovine medulla tissue homogenates showed the principal adrenal medullary immuno-reactive species to have ...

journal_title：Endocrine research

authors： Lo YC,MacKenzie SM,Howie AF,Apps DK,Mason JI,Williams BC,Morley SD

更新日期：2000-11-01 00:00:00

abstract：:StAR increases the flow of cholesterol from the outer to inner mitochondrial membrane (OMM to IMM), but its mechanism of action remains unclear. MLN64 is a 445 amino acid protein of unknown function that has four N-terminal transmembrane domains and whose C-terminal domain from 218-445 is 37% identical to StAR. N-62 S...

journal_title：Endocrine research

authors： Bose HS,Baldwin MA,Miller WL

更新日期：2000-11-01 00:00:00

abstract：:We have recently reported on the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK) and carbonic anhydrase I (CA-I) and II (CA-II) isoenzymes obtained from erythrocytes of healthy subjects and untreated patients with hyperthyroid diseases. Also, erythrocyte zinc concentrations were measured. Red b...

journal_title：Endocrine research

authors： Odçikin E,Ozdemir H,Ciftçi M,Capoğlu I

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:The diagnosis and management of osteoporosis and osteoporotic fractures are challenging in rural and underdeveloped areas of China because medical resources are inaccessible; thus, a simple and accurate method is essential for the detection of vertebral fractures. We aimed to examine the relationship between...

journal_title：Endocrine research

authors： Chen R,Liu S,Huang M,Ou Y,Liu W,Cui R,Yuan L,Xie Z,Sheng Z,Liu H

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...

journal_title：Endocrine research

authors： Kutoh E,Hori T

更新日期：2013-08-01 00:00:00

abstract：:The presence of vasoactive intestinal peptide and neuropeptide Y in thyroid nerves and their effects on thyroid blood flow are well known. However, the effects of these two neuropeptides on the various processes involved in thyroid hormone biosynthesis and release have not been fully explored. We have now tested these...

journal_title：Endocrine research

authors： Pietrzyk Z,Michalkiewicz M,Huffman LJ,Hedge GA

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. OBJECTIVES:Th...

journal_title：Endocrine research

authors： Trevizam PG,Tagliarini JV,Castilho EC,de Alencar Marques M,Kiy Y,Mazeto GMFS

更新日期：2017-02-01 00:00:00

abstract：:TRH is negatively regulated by T3 both in the hypothalamic paraventricular nucleus and transient transfection models. Mutations in hTR beta 1 genes are associated with the syndrome of generalized resistance to thyroid hormone. To investigate potential effects of mutant TRs on T3 regulation of the hTRH gene, transient ...

journal_title：Endocrine research

authors： Li QL,Feng P,Satoh T,Shi ZX,Wang R,Weintraub BD,Wilber JF

更新日期：1997-11-01 00:00:00

abstract：:In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...

journal_title：Endocrine research

authors： White PC,Hautanen A,Kupari M

更新日期：1998-08-01 00:00:00

abstract：:Type 1 angiotensin II (AII) receptors (AT1 receptors), besides stimulation of aldosterone secretion, seem to transduce the growth factor-like activity of AII on glomerulosa cells. Although a local renin-angiotensin system and AII synthesis have been found in human adrenals and aldosteronomas, it is unclear whether ald...

journal_title：Endocrine research

authors： Sarzani R,Opocher G,Dessì-Fulgheri P,Paci V,Cola G,Rocco S,Vianello B,Mantero F,Rappelli A

更新日期：1995-02-01 00:00:00

abstract：:Activation of calcium-activated, phospholipid-dependent protein kinase C by phorbol esters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) has been shown to mediate release of hormones in many systems. To investigate the role of protein kinase C in the mechanism of pituitary ACTH release, we studied the effect of ...

journal_title：Endocrine research

authors： Sobel DO

更新日期：1988-01-01 00:00:00

abstract：:Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...

journal_title：Endocrine research

authors： Kawai Y,Clark MR

更新日期：1986-01-01 00:00:00

abstract：:Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...

journal_title：Endocrine research

authors： Pon LA,Epstein LF,Orme-Johnson NR

更新日期：1986-01-01 00:00:00

abstract：:The liver is known to be sensitive to dietary challenge and to reduction in its functional mass. To investigate the influence of the vitamin D endocrine system on the hepatic growth response, liver DNA synthesis (S phase of cell cycle) was primed by dietary manipulation (high carbohydrate/protein-free diet x 3 d follo...

journal_title：Endocrine research

authors： Ethier C,Goupil D,Gascon-Barré M

更新日期：1991-01-01 00:00:00

abstract：:CYP17 is not expressed in adult mouse adrenal glands but is expressed in a subset of fetal adrenocortical cells, indicating the potential to produce both corticosterone and cortisol during murine embryogenesis. CYP11A is expressed in the fetal adrenal but also in developing hindgut, which will form the colon, and in c...

journal_title：Endocrine research

authors： Keeney DS

更新日期：1995-02-01 00:00:00

abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...

journal_title：Endocrine research

authors： Karbownik M,Zasada K,Wyczechowska D,Lewiński A,Fabianowska-Majewska K

更新日期：2002-08-01 00:00:00

abstract：:The zonal distribution of aldosterone synthase cytochrome P450 (P450aldo) in the adrenal cortex of male hamsters was investigated by immunofluorescence and electron microscopy, using an anti-P450aldo peptide antibody. On cryostat sections the immunolocalization of P450aldo was confined to the zona glomerulosa cells. O...

journal_title：Endocrine research

authors： LeHoux JG,Martel D,LeHoux J,Ducharme L,Lefebvre A,Brière N

更新日期：1995-02-01 00:00:00

abstract：:Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...

journal_title：Endocrine research

authors： Afeltra A,Paggi A,Ferri GM,Amoroso A,Di Prima MA,Startari S,Faralli AR,Bonomo L

更新日期：1993-03-01 00:00:00

abstract：:Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...

journal_title：Endocrine research

authors： Arlt W,Callies F,Allolio B

更新日期：2000-11-01 00:00:00

abstract：:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...

journal_title：Endocrine research

authors： Bokov AF,Ko D,Richardson A

更新日期：2009-01-01 00:00:00

abstract：:The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor. For estrogen receptor, proteasome inhibition decreases ligand-mediated transcription. We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in...

journal_title：Endocrine research

authors： Yokota K,Shibata H,Kobayashi S,Suda N,Murai A,Kurihara I,Saito I,Saruta T

更新日期：2004-11-01 00:00:00

abstract：:Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown. There is evidence for antiproliferative effects of DHEAS in neoplastic tissue. The present study was designed to investigate the effects of DHEAS on vascu...

journal_title：Endocrine research

authors： Hinson JP,Khan M

更新日期：2004-11-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00