Abstract:
:The liver is known to be sensitive to dietary challenge and to reduction in its functional mass. To investigate the influence of the vitamin D endocrine system on the hepatic growth response, liver DNA synthesis (S phase of cell cycle) was primed by dietary manipulation (high carbohydrate/protein-free diet x 3 d followed by high protein diet x 15-18 hr) in animals presenting various calcium and vitamin D status. Data indicate the dietary manipulation increased [3H]thymidine incorporation into DNA following vitamin D3 (D3) or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) administration (p less than 0.0001) while vitamin D depleted (D-) rats (both hypo and normocalcemic) showed no significant increases over unchallenged rats (p less than 0.0001). Studies on the hepatic EGF receptor indicate that while no significant between-group difference was observed in receptor density or affinity, evaluation of the receptor density in relation to the [3H]thymidine incorporation response revealed a higher receptor density in responders (D3 and 1,25(OH)2D3 supplemented groups) with 30.2 +/- 1.4% maximum binding than in non-responders (hypo and normocalcemic D- groups) with 25.4 +/- 1.8% maximum EGF binding (p less than 0.03); EGF EC50 was found to be 50.2 +/- 4.4 and 63.8 +/- 9.7 ng/ml in responders and non-responders respectively (p = 0.1). These data indicate that vitamin D depletion is accompanied by hyporesponsiveness when challenged by a dietary protocol known to prime the liver for growth inducing stimuli.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Ethier C,Goupil D,Gascon-Barré Mdoi
10.1080/07435809109106818subject
Has Abstractpub_date
1991-01-01 00:00:00pages
421-36issue
3-4eissn
0743-5800issn
1532-4206journal_volume
17pub_type
杂志文章abstract::The prostate gland of humans and other animals has the unique function of accumulating and secreting extraordinarily high levels of citrate. The prostate secretory epithelial cells synthesize citrate which, due to a limiting mitochondrial (m-) aconitase, accumulates rather than being oxidized. Thus citrate is essentia...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800009040143
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVES:The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between th...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2011.640374
更新日期:2012-01-01 00:00:00
abstract::The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200043623
更新日期:2004-11-01 00:00:00
abstract::The secretory activity of the adrenal gland is mainly regulated by peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now increasing evidence that local factors, including neuropeptides and neurotransmitters, can also participate in the control of adrenocortical cells. In particular, serotonin (5-...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032670
更新日期:1998-08-01 00:00:00
abstract::Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2013.875038
更新日期:2014-01-01 00:00:00
abstract::Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808709035466
更新日期:1987-01-01 00:00:00
abstract::The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032700
更新日期:1998-08-01 00:00:00
abstract::This study was performed on 18 postmenopausal female volunteers in order to examine changes in sex hormone binding globulin (SHBG), high density lipoprotein cholesterol (HDLC), total cholesterol (TC) and serum triglyceride (TG) levels in a period of four months of moderate physical exercise. While SHBG decreased signi...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209111036
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to examine the effects of exercise on anterior pituitary hormones (adrenocorticotropic hormone (ACTH), leutinizing hormone (LH) and growth hormone) as well as on cortisol at low altitude (350 meters below the sea level) and to compare these effects with those at a moderate level altitude ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809609030513
更新日期:1996-08-01 00:00:00
abstract::Hashimoto's thyroiditis (HT) is one of the most common organ-specific autoimmune diseases. Increasing evidence indicates that HT may be characterized by an imbalance in the helper T cell subsets Th1 and Th2. Traditional Chinese Medicine (TCM) considers HT as a chronic exhaustion disease, leading to deficiency of qi. I...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2015.1066800
更新日期:2016-01-01 00:00:00
abstract::Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cell...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048632
更新日期:2000-11-01 00:00:00
abstract::The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120016801
更新日期:2002-11-01 00:00:00
abstract::The steady state level of most cellular phosphoproteins is dependent on the relative catalytic activities of intracellular protein kinases and phosphatases. In adrenal cortex, ACTH acts through PKA activation and Ser/Tre phosphorylation. Phosphatases involved in this pathway are not completely described, particularly ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032618
更新日期:1998-08-01 00:00:00
abstract::Neutrophils have an important role in the host defense. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. The causes of these impairments are not clear. We aimed to investigate changes of peripheral neutrophil counts and functions and their relatio...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809909066155
更新日期:1999-08-01 00:00:00
abstract:UNLABELLED:Absract Purpose: Mutations in the TPO gene have been reported to cause congenital hypothyroidism (CH), and our aim in this study was to determine the genetic basis of congenital hypothyroidism in two affected children coming from a consanguineous family. METHODS:Since CH is usually inherited in autosomal re...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2014.967354
更新日期:2015-01-01 00:00:00
abstract::Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808609035438
更新日期:1986-01-01 00:00:00
abstract::In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809409030414
更新日期:1994-11-01 00:00:00
abstract::Diabetes mellitus impairs ventricular function, which itself may be disparately influenced by gender. This study compared the impact of gender on cardiac contractile response in ventricular myocytes from wild-type FVB and calmodulin-induced diabetic transgenic (OVE26) mice at young (2 month) and older (11 month) age. ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120022318
更新日期:2003-05-01 00:00:00
abstract::We report a novel mutant of the luteinizing hormone receptor (LHR) in a case of familial Leydig cell hypoplasia and pseudohermaphrotidism. The proband was homozygous for two missense mutations, T1121C and C1175T, causing substitutions I374T and T3921. The molecular effects of the mutations were investigated by heterol...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800500430890
更新日期:2005-01-01 00:00:00
abstract::StAR increases the flow of cholesterol from the outer to inner mitochondrial membrane (OMM to IMM), but its mechanism of action remains unclear. MLN64 is a 445 amino acid protein of unknown function that has four N-terminal transmembrane domains and whose C-terminal domain from 218-445 is 37% identical to StAR. N-62 S...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800009048583
更新日期:2000-11-01 00:00:00
abstract:UNLABELLED:It remains difficult to pre-operatively differentiate follicular carcinoma and adenoma even under intraoperative investigations including histopathologic diagnosis of frozen sections. METHODS:We retrospectively compared dual phase thallium (Tl-201) thyroid scan and fine-needle aspiration (FNA) cytology to d...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120025036
更新日期:2003-08-01 00:00:00
abstract::Pretreatment of confluent human fibroblast cultures for two days in dexamethasone, serum free medium increased 10-20 fold the sensitivity of the cells to insulin-like growth factor I (IGF I) stimulation of amino acid uptake using the amino acid analog alpha-aminoisobutyric acid (AIB). This increased sensitivity result...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808909042743
更新日期:1989-01-01 00:00:00
abstract:AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2016.1155597
更新日期:2017-02-01 00:00:00
abstract::The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800902913600
更新日期:2009-01-01 00:00:00
abstract::11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043775
更新日期:1996-11-01 00:00:00
abstract::The CYP11B2 gene encodes aldosterone synthase, a cytochrome P450 (P450aldo) expressed in high levels in the adrenal zona glomerulosa. While the primary physiologic regulators of aldosterone production are circulating angiotensin II (Ang II) and potassium (K+) the action of these agents on CYP11B2 gene transcription ha...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043735
更新日期:1996-11-01 00:00:00
abstract::Two CYP21 genes, the active CYP21 and the pseudogene, CYP21P, also pairs of duplicated genes including the XA, XB, XB-S; YA, YB; and ZA, ZB are arranged in tandem next to the serum complement C4 genes (C4A and C4B). In this report, we have analyzed the influence of some DNA sequences within the C4A/CYP21P region on th...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032659
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2012.745128
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) are common medications in Chinese patients with hyperthyroidism and PTU-induced antineutrophil cytoplasmic antibody (ANCA) positive vasculitis has been reported. The current cross-sectional study aimed to investigate the prevalence and the...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120037729
更新日期:2004-05-01 00:00:00
abstract::The recent cloning of a family of melanocortin receptors (MC-R) has identified five distinct G protein- and adenylate cyclase-coupled receptors. The MC2-receptor (MC2-R) preferentially binds ACTH. It is expressed in the adrenal cortex and is hence considered to be the ACTH receptor. The MC5-receptor (MC5-R) binds ACTH...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032628
更新日期:1998-08-01 00:00:00