Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat.

Abstract:

:Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.

journal_name

Endocr Res

journal_title

Endocrine research

authors

Passaro EA,Meltzer HY,Gudelsky GA

doi

10.3109/07435808709023671

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

173-82

issue

2

eissn

0743-5800

issn

1532-4206

journal_volume

13

pub_type

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