Molecular mechanisms of cell cycle control in the mouse Y1 adrenal cell line.

abstract：:The zonal distribution of aldosterone synthase cytochrome P450 (P450aldo) in the adrenal cortex of male hamsters was investigated by immunofluorescence and electron microscopy, using an anti-P450aldo peptide antibody. On cryostat sections the immunolocalization of P450aldo was confined to the zona glomerulosa cells. O...

journal_title：Endocrine research

authors： LeHoux JG,Martel D,LeHoux J,Ducharme L,Lefebvre A,Brière N

更新日期：1995-02-01 00:00:00

abstract：:Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes...

journal_title：Endocrine research

authors： Monden T,Mizuma H,Yamada M,Murakami M,Mori M

更新日期：1995-11-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1) levels were found to be associated with obesity, indicating that adipocytes might influence PAI-1 plasma levels. In addition, the 4G/5G promoter polymorphism of the PAI-1 gene possibly modulates PAI-1 gene transcription and, as a consequence, PAI-1 plasma levels. Metabolic par...

journal_title：Endocrine research

authors： Zietz B,Buechler C,Drobnik W,Herfarth H,Schölmerich J,Schäffler A

更新日期：2004-08-01 00:00:00

abstract：:Diabetes mellitus impairs ventricular function, which itself may be disparately influenced by gender. This study compared the impact of gender on cardiac contractile response in ventricular myocytes from wild-type FVB and calmodulin-induced diabetic transgenic (OVE26) mice at young (2 month) and older (11 month) age. ...

journal_title：Endocrine research

authors： Zhang X,Ye G,Duan J,Chen AF,Ren J

更新日期：2003-05-01 00:00:00

abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...

journal_title：Endocrine research

authors： Wynn J,Shah U,Murray SA

更新日期：2002-11-01 00:00:00

abstract：:We established cell lines from adrenal tumors of transgenic mice harboring the large T-antigen of simian virus 40 under the control of the adrenocortical specific promoter of the scavenger aldose reductase-like akr1b7 gene. Mass spectrometry analyses of serum-supplemented or serum-free culture media showed that ATC1 l...

journal_title：Endocrine research

authors： Ragazzon B,Lefrançois-Martinez AM,Val P,Tournaire C,Berger M,Gachancard-Bouya JL,Bègue RJ,Veyssière G,Martinez A

更新日期：2004-11-01 00:00:00

abstract：:The recent cloning of a family of melanocortin receptors (MC-R) has identified five distinct G protein- and adenylate cyclase-coupled receptors. The MC2-receptor (MC2-R) preferentially binds ACTH. It is expressed in the adrenal cortex and is hence considered to be the ACTH receptor. The MC5-receptor (MC5-R) binds ACTH...

journal_title：Endocrine research

authors： Liakos P,Chambaz EM,Feige JJ,Defaye G

更新日期：1998-08-01 00:00:00

abstract：:Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...

journal_title：Endocrine research

authors： Daussac A,Barat P,Servant N,Yacoub M,Missonier S,Lavran F,Gaspari L,Sultan C,Paris F

更新日期：2020-02-01 00:00:00

abstract：:Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...

journal_title：Endocrine research

authors： Arlt W,Callies F,Allolio B

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastograph...

journal_title：Endocrine research

authors： Mansor M,Okasha H,Esmat S,Hashem AM,Attia KA,El-din Hussein H

更新日期：2012-01-01 00:00:00

abstract：:A study was conducted to provide information on the characteristics of skeletal muscle glucocorticoid receptors and to determine the response of serum cortisol and thyroxine secretion to colostrum feeding in the neonatal calf. Twenty-four calves (12 males and 12 females) were obtained immediately postpartum and random...

journal_title：Endocrine research

authors： Waggoner DK,McCarthy FD,Akers RM

更新日期：1988-01-01 00:00:00

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the expression of the glucose transporters GLUT1 and GLUT3 in papillary thyroid carcinomas (PTCs) and to elucidate their relationship with the BRAF V600E mutation and F-18 FDG uptake. MATERIALS AND METHODS:We retrospectively analyzed data of 52 PTC patients (41 women a...

journal_title：Endocrine research

authors： Yoon M,Jung SJ,Kim TH,Ha TK,Urm SH,Park JS,Lee SM,Bae SK

更新日期：2016-01-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is one of the most common organ-specific autoimmune diseases. Increasing evidence indicates that HT may be characterized by an imbalance in the helper T cell subsets Th1 and Th2. Traditional Chinese Medicine (TCM) considers HT as a chronic exhaustion disease, leading to deficiency of qi. I...

journal_title：Endocrine research

authors： Chen J,Feng X,Huang Q

更新日期：2016-01-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency is the most frequent cause of congenital adrenal hyperplasia, an inherited inability to synthesize cortisol. Mutations causing this disorder have been characterized by hybridization analysis of patient DNA samples using cDNA and oligonucleotide probes, and by cloning and sequencing of...

journal_title：Endocrine research

authors： White PC

更新日期：1989-01-01 00:00:00

abstract：:Hippocampal functions are influenced by steroid hormones, such as testosterone and estradiol. It has been demonstrated that hippocampus-derived steroid hormones play important roles in neuronal protection and synapse formation. Our research groups have demonstrated that estradiol is de novo synthesized in the rat hipp...

journal_title：Endocrine research

authors： Munetsuna E,Hattori M,Yamazaki T

更新日期：2014-01-01 00:00:00

abstract：:Pertussis toxin (PT) and cholera toxin (CT) have been shown to modulate lactogenic hormone-stimulated Nb2 cell mitogenesis, a lactogen-dependent cell line. As both toxins have been shown to alter guanylate cyclase activity in other cell systems, cyclic guanosine monophosphate (cGMP) analogs, 8-bromo or dibutyryl cGMP,...

journal_title：Endocrine research

authors： Larsen JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. OBJECTIVE:The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpubli...

journal_title：Endocrine research

authors： Davis PJ,Glinsky GV,Lin HY,Incerpi S,Davis FB,Mousa SA,Tang HY,Hercbergs A,Luidens MK

更新日期：2013-01-01 00:00:00

abstract：:Two P450c11 genes, sharing 99% homology, were cloned from Cape baboon adrenal tissue using RT-PCR. The cDNAs showed 96% and 94.6% sequence identity to human P450c11 and aldosterone synthase, respectively. One of the gene sequences contained a termination codon in exon one. The cloned cDNAs were expressed in COS 1 cell...

journal_title：Endocrine research

authors： Swart AC,Brown N,Kolar N,Swart P

更新日期：2000-11-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：:We studied whether the activation of rat brown adipose tissue (BAT) by cold exposure or by the administration of beta-3-noradrenergic agonist CGP-12177 could be prevented by the inhibition of thyroxine (T4) to triiodothyronine (T3) conversion. Hypothyroid rats were treated with replacement doses of T4, T4 plus iopanoi...

journal_title：Endocrine research

authors： Zaninovich AA,Rebagliati I,Raíces M,Ricci C,Hagmüller K

更新日期：2000-05-01 00:00:00

abstract：:Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...

journal_title：Endocrine research

authors： Afeltra A,Paggi A,Ferri GM,Amoroso A,Di Prima MA,Startari S,Faralli AR,Bonomo L

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:The diagnosis and management of osteoporosis and osteoporotic fractures are challenging in rural and underdeveloped areas of China because medical resources are inaccessible; thus, a simple and accurate method is essential for the detection of vertebral fractures. We aimed to examine the relationship between...

journal_title：Endocrine research

authors： Chen R,Liu S,Huang M,Ou Y,Liu W,Cui R,Yuan L,Xie Z,Sheng Z,Liu H

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a cri...

journal_title：Endocrine research

authors： Karakose M,Caliskan M,Arslan MS,Demirci T,Karakose S,Tutal E,Cakal E

更新日期：2018-02-01 00:00:00

abstract：:Four hundred micrograms of synthetic thyrotropin releasing hormone (TRH) were given intravenously to 4 normal men and 4 normal women, and four weeks later, 1000 micrograms of TRH were administered intravenously to 4 of the 8 individuals and oxytocin (OT) was measured in plasma on both occasions. Following injection of...

journal_title：Endocrine research

authors： Amico JA,Johnston JM

更新日期：1985-01-01 00:00:00

abstract：:Two CYP21 genes, the active CYP21 and the pseudogene, CYP21P, also pairs of duplicated genes including the XA, XB, XB-S; YA, YB; and ZA, ZB are arranged in tandem next to the serum complement C4 genes (C4A and C4B). In this report, we have analyzed the influence of some DNA sequences within the C4A/CYP21P region on th...

journal_title：Endocrine research

authors： Chang SF,Cheng CL

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:This retrospective and observational study aimed to establish whether any relationship exists between the values of serum thyroid-stimulating hormone (TSH) and those of the mean platelet volume (MPV) in a large cohort of older euthyroid Italian subjects. MATERIALS AND METHOD:The study population was represente...

journal_title：Endocrine research

authors： Lippi G,Danese E,Montagnana M,Nouvenne A,Meschi T,Borghi L

更新日期：2015-01-01 00:00:00

abstract：:The prostate gland of humans and other animals has the unique function of accumulating and secreting extraordinarily high levels of citrate. The prostate secretory epithelial cells synthesize citrate which, due to a limiting mitochondrial (m-) aconitase, accumulates rather than being oxidized. Thus citrate is essentia...

journal_title：Endocrine research

authors： Costello LC,Liu Y,Zou J,Franklin RB

更新日期：2000-02-01 00:00:00

abstract：:In general, growth hormone acts as a factor promoting cell proliferation in the positive direction and suppresses apoptosis. No report has described growth hormone (GH)-induced structural luteolysis. The present studies showed that GH induced structural luteolysis in rats after the induction of functional luteolysis b...

journal_title：Endocrine research

authors： Kiya T,Endo T,Henmi H,Goto T,Kitajima Y,Manase K,Takahashi S,Kudo R

更新日期：1999-05-01 00:00:00

abstract：:The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein...

journal_title：Endocrine research

authors： Raza FS,Puddefoot JR,Vinson GP

更新日期：1998-08-01 00:00:00