Role of ultrasound elastography in prediction of malignancy in thyroid nodules.

abstract：:There are striking similarities between Cushing's syndrome and the 'metabolic syndrome X' since both are characterised by hypertension, insulin resistance, glucose intolerance, hyperlipidaemia, and central obesity. The possibility that cortisol contributes to the associations between multiple risk factors for cardiova...

journal_title：Endocrine research

authors： Walker BR

更新日期：1996-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：:The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor. For estrogen receptor, proteasome inhibition decreases ligand-mediated transcription. We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in...

journal_title：Endocrine research

authors： Yokota K,Shibata H,Kobayashi S,Suda N,Murai A,Kurihara I,Saito I,Saruta T

更新日期：2004-11-01 00:00:00

abstract：:The present work was to study if the alpha-melanocyte-stimulating hormone (alpha-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracereb...

journal_title：Endocrine research

authors： Vecsernyés M,Biró E,Gardi J,Julesz J,Telegdy G

更新日期：2000-08-01 00:00:00

abstract：:Metabolic syndrome was first proposed in 1988 and has been recognized as a powerful predictor for cardiovascular disease and diabetes. At the same time, white blood cell count (WBCC) was proposed to have significant correlation with metabolic syndrome (MS). In this study, we attempted to investigate the relationship b...

journal_title：Endocrine research

authors： Chuo SK,Li JC,Tsai WC,Wu DA,Kuo SW,Pei D,Chen SP,Shen DC

更新日期：2005-01-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is one of the most common organ-specific autoimmune diseases. Increasing evidence indicates that HT may be characterized by an imbalance in the helper T cell subsets Th1 and Th2. Traditional Chinese Medicine (TCM) considers HT as a chronic exhaustion disease, leading to deficiency of qi. I...

journal_title：Endocrine research

authors： Chen J,Feng X,Huang Q

更新日期：2016-01-01 00:00:00

abstract：:We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line. Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not. The MEK1 inhibitor PD98...

journal_title：Endocrine research

authors： LeHoux JG,Lefebvre A

更新日期：2004-11-01 00:00:00

abstract：:The CYP11B2 gene encodes aldosterone synthase, a cytochrome P450 (P450aldo) expressed in high levels in the adrenal zona glomerulosa. While the primary physiologic regulators of aldosterone production are circulating angiotensin II (Ang II) and potassium (K+) the action of these agents on CYP11B2 gene transcription ha...

journal_title：Endocrine research

authors： Clyne CD,White PC,Rainey WE

更新日期：1996-11-01 00:00:00

abstract：:The question of whether ethanol's (ETOH's) known suppressive effect on serum luteinizing hormone (LH) could be mediated directly at the anterior pituitary level was addressed by examining the effects of ETOH in vitro on release of LH from cultured male rat pituitary cells. The impact of added ethanol concentrations ra...

journal_title：Endocrine research

authors： Emanuele MA,Tentler J,Emanuele NV,Reda D,Kirsteins L,Lawrence AM

更新日期：1989-01-01 00:00:00

abstract：:The liver is known to be sensitive to dietary challenge and to reduction in its functional mass. To investigate the influence of the vitamin D endocrine system on the hepatic growth response, liver DNA synthesis (S phase of cell cycle) was primed by dietary manipulation (high carbohydrate/protein-free diet x 3 d follo...

journal_title：Endocrine research

authors： Ethier C,Goupil D,Gascon-Barré M

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether 25-hydroxyvitamin D [25(OH)D] can mediate effects without being converted to 1α,25-dihydroxyvitamin D [1,25(OH)2D]. METHODS:Vitamin D3 (VD3) was injected intramuscularly to 25-hydroxyvitamin D-1α-hydroxylase [1α(OH)ase] gene knockout (KO) male mice with a dose of 10,000 IU per week for...

journal_title：Endocrine research

authors： Zhang ZL,Ding XF,Tong J,Li BY

更新日期：2011-01-01 00:00:00

abstract：:Cerebrovascular accidents are one of the life-threatening complications of diabetic ketoacidosis (DKA) in children and adolescents. Our objective was to evaluate the effect of DKA and its treatment on factors known to affect thrombotic activity (protein C; protein S; von Willebrand factor, fibrinogen; homocysteine; an...

journal_title：Endocrine research

authors： Carl GF,Hoffman WH,Passmore GG,Truemper EJ,Lightsey AL,Cornwell PE,Jonah MH

更新日期：2003-02-01 00:00:00

abstract：:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...

journal_title：Endocrine research

authors： Bokov AF,Ko D,Richardson A

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the expression of the glucose transporters GLUT1 and GLUT3 in papillary thyroid carcinomas (PTCs) and to elucidate their relationship with the BRAF V600E mutation and F-18 FDG uptake. MATERIALS AND METHODS:We retrospectively analyzed data of 52 PTC patients (41 women a...

journal_title：Endocrine research

authors： Yoon M,Jung SJ,Kim TH,Ha TK,Urm SH,Park JS,Lee SM,Bae SK

更新日期：2016-01-01 00:00:00

abstract：:The zonal distribution of aldosterone synthase cytochrome P450 (P450aldo) in the adrenal cortex of male hamsters was investigated by immunofluorescence and electron microscopy, using an anti-P450aldo peptide antibody. On cryostat sections the immunolocalization of P450aldo was confined to the zona glomerulosa cells. O...

journal_title：Endocrine research

authors： LeHoux JG,Martel D,LeHoux J,Ducharme L,Lefebvre A,Brière N

更新日期：1995-02-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：:This study was performed on 18 postmenopausal female volunteers in order to examine changes in sex hormone binding globulin (SHBG), high density lipoprotein cholesterol (HDLC), total cholesterol (TC) and serum triglyceride (TG) levels in a period of four months of moderate physical exercise. While SHBG decreased signi...

journal_title：Endocrine research

authors： Caballero MJ,Maynar M

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Increasing evidence exists that hyperprolactinemia alters metabolic profile. The mechanism of this effect is unknown. We aimed to investigate the differences between the metabolic profile of patients with prolactinomas and nonfunctional pituitary adenomas and to evaluate the impact of other pituitary hormones o...

journal_title：Endocrine research

authors： Perić B,Kruljac I,Šundalić S,Pećina HI,Jović A,Štefanović M,Butorac D,Vrkljan M

更新日期：2016-08-01 00:00:00

abstract：AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...

journal_title：Endocrine research

authors： Simental-Mendía LE,Simental-Mendía E,Rodríguez-Morán M,Guerrero-Romero F

更新日期：2017-02-01 00:00:00

abstract：:Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects a...

journal_title：Endocrine research

authors： Agarwal AK

更新日期：2003-11-01 00:00:00

abstract：:In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...

journal_title：Endocrine research

authors： White PC,Hautanen A,Kupari M

更新日期：1998-08-01 00:00:00

abstract：:The MA-10 mouse Leydig tumor cell line produces large amounts of steroids only in response to hormonal stimulation while the R2C rat Leydig tumor cell line is constitutively steroidogenic in nature. In an effort to uncover the potential reasons for constitutive steroidogenesis in R2C cells, we have recently shown that...

journal_title：Endocrine research

authors： Rao RM,Jo Y,Babb-Tarbox M,Syapin PJ,Stocco DM

更新日期：2002-11-01 00:00:00

abstract：:We have recently reported on the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK) and carbonic anhydrase I (CA-I) and II (CA-II) isoenzymes obtained from erythrocytes of healthy subjects and untreated patients with hyperthyroid diseases. Also, erythrocyte zinc concentrations were measured. Red b...

journal_title：Endocrine research

authors： Odçikin E,Ozdemir H,Ciftçi M,Capoğlu I

更新日期：2002-02-01 00:00:00

abstract：:The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in...

journal_title：Endocrine research

authors： Bicknell AB

更新日期：2002-11-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes in the elderly people. Previous studies have reported the sex differences in risk for type 2 diabetes, especially in the elderly people, whereas reasons for these sex differences remain poorly understood...

journal_title：Endocrine research

authors： Li T,Jiao W,Li W,Li H

更新日期：2016-08-01 00:00:00

abstract：:TRH is negatively regulated by T3 both in the hypothalamic paraventricular nucleus and transient transfection models. Mutations in hTR beta 1 genes are associated with the syndrome of generalized resistance to thyroid hormone. To investigate potential effects of mutant TRs on T3 regulation of the hTRH gene, transient ...

journal_title：Endocrine research

authors： Li QL,Feng P,Satoh T,Shi ZX,Wang R,Weintraub BD,Wilber JF

更新日期：1997-11-01 00:00:00

abstract：:The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein...

journal_title：Endocrine research

authors： Raza FS,Puddefoot JR,Vinson GP

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determin...

journal_title：Endocrine research

authors： Calan M,Kume T,Yilmaz O,Arkan T,Kocabas GU,Dokuzlar O,Aygün K,Oktan MA,Danıs N,Temur M

更新日期：2016-08-01 00:00:00

abstract：:Two distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) with respect to enzymatic activity were identified in the ovine liver and kidney. 11 beta-HSD1 (the hepatic isoform) was reversible and NADP(H)-dependent. By contrast, 11 beta-HSD2 (the renal isoform) was unidirectional and NAD-dependent. Ovin...

journal_title：Endocrine research

authors： Yang K

更新日期：1995-02-01 00:00:00