Perspectives in steroid hydroxylase gene expression: novel sites of expression during embryonic development.

abstract：:The mechanisms by which SF-1 (Steroidogenic Factor-1) and Dax-1 (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome) dictate adrenal-specific transcriptional programs are the focus of this laboratory. SF-1-mediated transcription is upregulated by phosphorylation of serine 20...

journal_title：Endocrine research

authors： Babu PS,Bavers DL,Shah S,Hammer GD

更新日期：2000-11-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：:Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...

journal_title：Endocrine research

authors： White PC,Dupont B,New MI

更新日期：1984-01-01 00:00:00

abstract：:Y1 cells derived from mouse tumor zona fasciculata cells (ZF) were used to assess the importance of extracellular (EC) calcium availability via voltage-dependent calcium channels (VDCC) on steroidogenesis. The steroidogenic response to ACTH was investigated in the presence of blockers known to affect both calcium and ...

journal_title：Endocrine research

authors： Coyne MD,Wang G,Lemos JR

更新日期：1996-11-01 00:00:00

abstract：:We have recently reported on the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK) and carbonic anhydrase I (CA-I) and II (CA-II) isoenzymes obtained from erythrocytes of healthy subjects and untreated patients with hyperthyroid diseases. Also, erythrocyte zinc concentrations were measured. Red b...

journal_title：Endocrine research

authors： Odçikin E,Ozdemir H,Ciftçi M,Capoğlu I

更新日期：2002-02-01 00:00:00

abstract：:Thyroid dysfunction influences the levels of Von Willebrand factor (VWF:Ag). Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels. A follow-up study of seven hyperthyroid patients undergoing anti-thyroid...

journal_title：Endocrine research

authors： Liu L,Wang X,Lin Z,Wu H

更新日期：1993-01-01 00:00:00

abstract：:A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea ...

journal_title：Endocrine research

authors： Bani Hani I,El-Migdadi F,Shotar A,Abudheese R,Bashir N

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...

journal_title：Endocrine research

authors： Kutoh E,Hori T

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:The aim of the present study was to investigate the association between plasma homocysteine (Hcy) levels and carotid, cardiac, and renal end-organ damage in newly diagnosed type 2 diabetes mellitus (T2DM) patients. METHODS:Newly diagnosed normotensive T2DM patients (n = 390) were enrolled in this study. The pa...

journal_title：Endocrine research

authors： Kundi H,Kiziltunc E,Ates I,Cetin M,Barca AN,Ozkayar N,Ornek E

更新日期：2017-02-01 00:00:00

abstract：:Purpose: Transthyretin (TTR) is a protein with a growing number of biological functions in addition to its well-established binding and circulatory transport of thyroxine, and indirect retinoid transport through interaction with retinol-binding protein. Misfolded and aggregated wild-type and mutant TTRs are involved i...

journal_title：Endocrine research

authors： Fong VH,Wong S,Jintaridhi P,Vieira A

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To determine whether daily oral micronized progesterone affects bone turnover, as estimated by serum and urine biochemical markers, in postmenopausal women on long-term estrogen replacement therapy (ERT). METHODS:We recruited 14 women aged 65 or older to participate in a 9-week trial with micronized progestero...

journal_title：Endocrine research

authors： Azizi G,Hansen A,Prestwood KM

更新日期：2003-05-01 00:00:00

abstract：UNLABELLED:Absract Purpose: Mutations in the TPO gene have been reported to cause congenital hypothyroidism (CH), and our aim in this study was to determine the genetic basis of congenital hypothyroidism in two affected children coming from a consanguineous family. METHODS:Since CH is usually inherited in autosomal re...

journal_title：Endocrine research

authors： Cangul H,Darendeliler F,Saglam Y,Kucukemre B,Kendall M,Boelaert K,Barrett TG,Maher ER

更新日期：2015-01-01 00:00:00

abstract：:Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...

journal_title：Endocrine research

authors： Pon LA,Epstein LF,Orme-Johnson NR

更新日期：1986-01-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：:Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by th...

journal_title：Endocrine research

authors： Passaro EA,Meltzer HY,Gudelsky GA

更新日期：1987-01-01 00:00:00

abstract：:There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement th...

journal_title：Endocrine research

authors： Onobrakpeya OA,Fall PM,Willard A,Chakravarthi P,Hansen A,Raisz LG

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship b...

journal_title：Endocrine research

authors： Arduc A,Aycicek Dogan B,Bilmez S,Imga Nasiroglu N,Tuna MM,Isik S,Berker D,Guler S

更新日期：2015-01-01 00:00:00

abstract：:In order to study the role of Platelet Activating Factor (PAF) in the mechanism of parturition and connective tissue metabolism in the pregnant rat uterus, we investigated the influence of the Platelet Activating Factor Receptor Antagonist (BN 52021) on gestation duration and collagen concentration in pregnant rat ute...

journal_title：Endocrine research

authors： Bieńkiewicz A,Pajszczyk-Kieszkiewicz T,Kuś E,Dabrowski R

更新日期：1994-11-01 00:00:00

abstract：:The rat adrenal cortex possesses at least two mechanisms for uptake of extracellular lipoprotein cholesterol; one is receptor mediated endocytosis and the second is a non-endocytotic pathway. The latter was revealed by the ability of lipoproteins such as HDL which do not possess apo B or apo E to enhance steroid hormo...

journal_title：Endocrine research

authors： Gwynne JT,Hess B,Hughes T,Rountree R,Mahaffee D

更新日期：1984-01-01 00:00:00

abstract：:A 30-residue peptide corresponding to the amino acid sequence of steroidogenesis activator peptide (SAP) from rat Leydig tumor cells has been synthesized by the solid-phase method using Boc protection. SAP is the putative cycloheximide-sensitive, cAMP-regulated mediator of ACTH-stimulated conversion of cholesterol to ...

journal_title：Endocrine research

authors： Glass DB,Robertson DG,Xu TS,Bowman EP,Lambeth JD

更新日期：1991-01-01 00:00:00

abstract：:The steady state level of most cellular phosphoproteins is dependent on the relative catalytic activities of intracellular protein kinases and phosphatases. In adrenal cortex, ACTH acts through PKA activation and Ser/Tre phosphorylation. Phosphatases involved in this pathway are not completely described, particularly ...

journal_title：Endocrine research

authors： Cornejo Maciel F,Paz C,Neuman MI,Podestá EJ

更新日期：1998-08-01 00:00:00

abstract：:Leptin, the product of the ob gene, is an adipose-tissue secreted hormone, which regulates satiety, metabolic rate and thermogenesis. Many lines of evidence suggest the existence of mutual relationships between leptin and adrenal-cortex secretion, but in vivo studies gave rather conflicting results. Therefore, we have...

journal_title：Endocrine research

authors： Malendowicz LK,Macchi C,Nussdorfer GG,Nowak KW

更新日期：1998-05-01 00:00:00

abstract：:The effects of forskolin on the regulation of steroidogenesis and growth were examined in the Y1 adrenocortical tumor cell line, and the roles of cAMP and cAMP-dependent protein kinase in these actions of forskolin were evaluated. Forskolin, like corticotropin, stimulated steroidogenesis 3-fold and inhibited growth by...

journal_title：Endocrine research

authors： Schimmer BP,Schulz P

更新日期：1985-01-01 00:00:00

abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...

journal_title：Endocrine research

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1994-05-01 00:00:00

abstract：:The present work was to study if the alpha-melanocyte-stimulating hormone (alpha-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracereb...

journal_title：Endocrine research

authors： Vecsernyés M,Biró E,Gardi J,Julesz J,Telegdy G

更新日期：2000-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：:Four hundred micrograms of synthetic thyrotropin releasing hormone (TRH) were given intravenously to 4 normal men and 4 normal women, and four weeks later, 1000 micrograms of TRH were administered intravenously to 4 of the 8 individuals and oxytocin (OT) was measured in plasma on both occasions. Following injection of...

journal_title：Endocrine research

authors： Amico JA,Johnston JM

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) are common medications in Chinese patients with hyperthyroidism and PTU-induced antineutrophil cytoplasmic antibody (ANCA) positive vasculitis has been reported. The current cross-sectional study aimed to investigate the prevalence and the...

journal_title：Endocrine research

authors： Gao Y,Zhao MH,Guo XH,Xin G,Gao Y,Wang HY

更新日期：2004-05-01 00:00:00

abstract：:There are several published reports on the prevalence of low vitamin D levels in otherwise healthy Indian population. Vitamin D deficiency has shown variable effect on muscle performance and strength but there is paucity of data on the effect of vitamin D deficiency on muscle energy metabolism. The present study was p...

journal_title：Endocrine research

authors： Rana P,Marwaha RK,Kumar P,Narang A,Devi MM,Tripathi RP,Khushu S

更新日期：2014-01-01 00:00:00

abstract：:The prostate gland of humans and other animals has the unique function of accumulating and secreting extraordinarily high levels of citrate. The prostate secretory epithelial cells synthesize citrate which, due to a limiting mitochondrial (m-) aconitase, accumulates rather than being oxidized. Thus citrate is essentia...

journal_title：Endocrine research

authors： Costello LC,Liu Y,Zou J,Franklin RB

更新日期：2000-02-01 00:00:00