Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta-adrenergic receptors.

Abstract:

:Thyroid dysfunction influences the levels of Von Willebrand factor (VWF:Ag). Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels. A follow-up study of seven hyperthyroid patients undergoing anti-thyroid therapy showed that the elevated VWF:Ag levels returned to normal range with the normalization of thyroid function. On the other hand, after administration of 160 mg/day of propranolol, a specific blocker of beta-adrenergic receptors, to five hyperthyroid patients for twenty-eight days, plasma VWF:Ag levels returned to normal range, while T3, T4 levels remained high without significant alteration. These results demonstrated that the elevation of plasma VWF:Ag by thyroid hormone is mediated through beta-adrenergic receptors, which may be useful to further understand the physiological and pathological roles of thyroid hormone in the regulation of VWF:Ag levels.

journal_name

Endocr Res

journal_title

Endocrine research

authors

Liu L,Wang X,Lin Z,Wu H

doi

10.3109/07435809309033019

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

123-33

issue

2-3

eissn

0743-5800

issn

1532-4206

journal_volume

19

pub_type

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