Abstract：
PURPOSE:Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS:The study consisted of 52 newly treated patients (73.3 ± 8.8 years) (new group) and 47 patients (75.9 ± 9.5 years) who were switched from either alendronate or risedronate (switch group). Monthly minodronate (50 mg/every 4 weeks) was administered for 27 months. Lumbar, femoral neck, and total hip BMDs and serum pentosidine were monitored at baseline and after 9, 18, and 27 months of treatment. RESULTS:In the new condition, lumbar, neck, and total hip BMDs increased significantly by 9.07%, 3.15%, and 3.06%, respectively. Only the lumbar BMD significantly increased in the switch condition. Serum Pen increased in both groups in a time-dependent manner. In the group switch, multivariate logistic regression analysis revealed that the initial change in serum intact procollagen type I N-terminal propeptide (P1NP) at 9 months was an independent predictor of changes in neck and total hip BMDs at 27 months (OR = 1.039, 95% CI 1.003-1.077, p = 0.032 for neck and OR = 1.055, 95% CI 1.009-1.104, p = 0.020 for total hip). CONCLUSIONS:Monthly minodronate treatment increased BMDs in newly treated patients over 27 months. Serum Pen increased with M-MIN therapy, possibly indicating prolonged bone turnover. The initial 9-month changes in serum P1NP predicted the 27-month changes in hip BMDs when M-MIN replaced alendronate or risedronate.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Ohishi T,Fujita T,Suzuki D,Nishida T,Yamamoto K,Okabayashi R,Ushirozako H,Banno T,Matsuyama Ydoi
10.1080/07435800.2017.1292527subject
Has Abstractpub_date
2017-08-01 00:00:00pages
232-240issue
3eissn
0743-5800issn
1532-4206journal_volume
42pub_type
杂志文章abstract：:In order to clarify the roles of cholinergic and serotonergic neurotransmission in the mediation of exercise-induced growth hormone (GH) release, normal young volunteers of both sexes were studied. Exercise was for 20 minutes at 800 kpm for the men and 500 kpm for the women. Pretreatment with 0.4 mg atropine 1 hour pr...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435808609035433
更新日期：1986-01-01 00:00:00
abstract：:The presence of vasoactive intestinal peptide and neuropeptide Y in thyroid nerves and their effects on thyroid blood flow are well known. However, the effects of these two neuropeptides on the various processes involved in thyroid hormone biosynthesis and release have not been fully explored. We have now tested these...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809209026678
更新日期：1992-01-01 00:00:00
abstract：:Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800.2019.1645163
更新日期：2020-02-01 00:00:00
abstract：:Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809009033011
更新日期：1990-01-01 00:00:00
abstract：:We report a novel mutant of the luteinizing hormone receptor (LHR) in a case of familial Leydig cell hypoplasia and pseudohermaphrotidism. The proband was homozygous for two missense mutations, T1121C and C1175T, causing substitutions I374T and T3921. The molecular effects of the mutations were investigated by heterol...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800500430890
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To determine whether daily oral micronized progesterone affects bone turnover, as estimated by serum and urine biochemical markers, in postmenopausal women on long-term estrogen replacement therapy (ERT). METHODS:We recruited 14 women aged 65 or older to participate in a 9-week trial with micronized progestero...
journal_title：Endocrine research
pub_type： 临床试验,杂志文章
doi：10.1081/erc-120022294
更新日期：2003-05-01 00:00:00
abstract：:The question of whether ethanol's (ETOH's) known suppressive effect on serum luteinizing hormone (LH) could be mediated directly at the anterior pituitary level was addressed by examining the effects of ETOH in vitro on release of LH from cultured male rat pituitary cells. The impact of added ethanol concentrations ra...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435808909042748
更新日期：1989-01-01 00:00:00
abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120016999
更新日期：2002-11-01 00:00:00
abstract：:There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement th...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-100107870
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:The aim of the present study was to investigate the association between plasma homocysteine (Hcy) levels and carotid, cardiac, and renal end-organ damage in newly diagnosed type 2 diabetes mellitus (T2DM) patients. METHODS:Newly diagnosed normotensive T2DM patients (n = 390) were enrolled in this study. The pa...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2016.1171235
更新日期：2017-02-01 00:00:00
abstract：:A method is described for the preparation of high yields of viable, dissociated cells from porcine theca interna and corpus luteum and from human and bovine endometrium. The tissues were dissociated by incubation at 37 degrees C in a mixture of 0.5% collagenase, 0.1% hyaluronidase and 0.1% pronase in balanced salt sol...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435808409035415
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. OBJECTIVE:The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpubli...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.3109/07435800.2013.778865
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Charcoal- or resin-stripping of fetal bovine serum (FBS) or bovine calf serum (BCS) intended for supplementation of cell culture media is widely practiced to remove a variety of endogenous compounds, including steroid, peptide, and thyroid hormones. The possibility that stripping removes other biologically...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800903204082
更新日期：2009-01-01 00:00:00
abstract：:Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435808609035438
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between th...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2011.640374
更新日期：2012-01-01 00:00:00
abstract：:A 30-residue peptide corresponding to the amino acid sequence of steroidogenesis activator peptide (SAP) from rat Leydig tumor cells has been synthesized by the solid-phase method using Boc protection. SAP is the putative cycloheximide-sensitive, cAMP-regulated mediator of ACTH-stimulated conversion of cholesterol to ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809109027204
更新日期：1991-01-01 00:00:00
abstract：:T3 receptors are ligand-dependent transcriptional activators that can stimulate gene expression resulting in growth and development. In this study T3 binding sites on isolated liver nuclei are demonstrated in the teleost Anabas testudineus. The effect of hypothyroidism and feeding of polyunsaturated fatty acids (PUFA)...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-100106010
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:Increasing evidence exists that hyperprolactinemia alters metabolic profile. The mechanism of this effect is unknown. We aimed to investigate the differences between the metabolic profile of patients with prolactinomas and nonfunctional pituitary adenomas and to evaluate the impact of other pituitary hormones o...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2015.1135444
更新日期：2016-08-01 00:00:00
abstract：:Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800.2018.1470639
更新日期：2018-11-01 00:00:00
abstract：:It was the aim of this study to test for a possible effect of the new non ergot dopamine agonist CV 205-502 on plasma growth hormone (GH) concentrations in acromegaly. 10 acromegalic patients received a single oral dose of 150 micrograms CV 205-502 after an overnight fast. As a control group 7 acromegalic patients und...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809409035856
更新日期：1994-02-01 00:00:00
abstract：:The objective of the current investigation was to study adrenomedullary and glycemic responses to stress in soft-shelled turtles, Lissemys p. punctata. Dehydration (7 days) and formalin (formaldehyde 1%, 0.1 mL/100 g body wt. daily for 7 days) stress-stimulated adrenomedullary activity at histological (by increasing t...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800802540263
更新日期：2008-01-01 00:00:00
abstract：:We studied whether the activation of rat brown adipose tissue (BAT) by cold exposure or by the administration of beta-3-noradrenergic agonist CGP-12177 could be prevented by the inhibition of thyroxine (T4) to triiodothyronine (T3) conversion. Hypothyroid rats were treated with replacement doses of T4, T4 plus iopanoi...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800009066164
更新日期：2000-05-01 00:00:00
abstract：:The liver is known to be sensitive to dietary challenge and to reduction in its functional mass. To investigate the influence of the vitamin D endocrine system on the hepatic growth response, liver DNA synthesis (S phase of cell cycle) was primed by dietary manipulation (high carbohydrate/protein-free diet x 3 d follo...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809109106818
更新日期：1991-01-01 00:00:00
abstract：:Comparison of binding of 125I-porcine FSH to porcine granulosa cells from small and large ovarian follicles indicated that binding is dependent on both time and temperature. At 37 C, binding of ligand is more than four times higher in cells from small follicles than in cells from large follicles within 30 minutes of t...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809409035857
更新日期：1994-02-01 00:00:00
abstract：:The effect of clomiphene on nuclear estrogen receptors of the Fallopian tube during ovum transport in the rabbit has been studied. Nuclear binding capacity was observed in ampulla (A), ampullary-isthmic junction (AIJ), isthmus (I), uterine-isthmic junction (UIJ) and uterus (U). Receptor concentration decreased in all ...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435808909042745
更新日期：1989-01-01 00:00:00
abstract：:Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435808409036505
更新日期：1984-01-01 00:00:00
abstract：:Progesterone (P) given intramuscularly increases renal sodium excretion. We tested the in vitro capacity of P to bind to the human mineralocorticoid receptor (MR) with a reticulocyte lysate system and Ps transactivation potency in transfected CV-1 cells. Progesterone binds with higher affinity to the MR than aldostero...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120016824
更新日期：2002-11-01 00:00:00
abstract：PURPOSE:Thyroglobulin (Tg) assessment in the needle washout after fine-needle aspiration biopsy (FNAB) of a suspicious neck lymph node (LN) is known to improve the diagnostic accuracy in patients with papillary thyroid cancer (PTC). However, there is still controversy on the best diagnostic cut-off levels for FNAB-Tg a...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2016.1141936
更新日期：2016-11-01 00:00:00
abstract：:Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secre...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809809032680
更新日期：1998-08-01 00:00:00
abstract：:Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435808609035449
更新日期：1986-01-01 00:00:00
