Abstract:
:The effect of clomiphene on nuclear estrogen receptors of the Fallopian tube during ovum transport in the rabbit has been studied. Nuclear binding capacity was observed in ampulla (A), ampullary-isthmic junction (AIJ), isthmus (I), uterine-isthmic junction (UIJ) and uterus (U). Receptor concentration decreased in all segments of the tube after administration of clomiphene in mated animals. The bindings are of high affinity and low capacity. Important alterations were observed during transport when compared to that of 14, 24, 34, 48, 72, 144 and 168 hr post-coitum (p.c). At 24 hr p.c binding increased only in I and decreased in A and AIJ. Retention of eggs at I at 24 hr p.c showed as increase in binding at I. Egg transport was accelerated and eggs reached prematurely in the uterus due to the influence of clomiphene. Binding in I remained constant from 48 hr p.c to 144 hr p.c but concurrently the binding level increased in U from 34 hr p.c. The elevation of nuclear estrogen receptor level was maximum at 24 hr p.c which coincided with increased plasma estrogen level. The result of such study showed that clomiphene depleted nuclear estrogen receptor complex in the fallopian tube before transfer to the uterus. Further, observation indicated that clomiphene acted directly on the rate of egg transport because of the variations in estrogen receptors during different time periods. Thus, clomiphene reduced the quantity of estrogen receptor i.e., insensitiveness to estrogen. The variations in estrogen binding to its receptor and plasma level at different post-coital periods are modulated by clomiphene resulting in the acceleration of egg transport and prevention of pregnancy.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Gupta JS,Roy SKdoi
10.3109/07435808909042745subject
Has Abstractpub_date
1989-01-01 00:00:00pages
339-53issue
3eissn
0743-5800issn
1532-4206journal_volume
15pub_type
杂志文章abstract::In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032690
更新日期:1998-08-01 00:00:00
abstract::Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto's thyro...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2013.875038
更新日期:2014-01-01 00:00:00
abstract::We quantitated serial serum beta-hydroxybutyrate (beta-OHB) levels using the Ketosite method in 9 children with IDDM who were treated for diabetic ketoacidosis (DKA) and compared them to urinary ketone measurements by dipstick. Persistent elevations of serum beta-OHB were seen in six patients when the urine became cle...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-100107168
更新日期:2001-02-01 00:00:00
abstract::This study was performed on 18 postmenopausal female volunteers in order to examine changes in sex hormone binding globulin (SHBG), high density lipoprotein cholesterol (HDLC), total cholesterol (TC) and serum triglyceride (TG) levels in a period of four months of moderate physical exercise. While SHBG decreased signi...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209111036
更新日期:1992-01-01 00:00:00
abstract::Diabetes mellitus impairs ventricular function, which itself may be disparately influenced by gender. This study compared the impact of gender on cardiac contractile response in ventricular myocytes from wild-type FVB and calmodulin-induced diabetic transgenic (OVE26) mice at young (2 month) and older (11 month) age. ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120022318
更新日期:2003-05-01 00:00:00
abstract::The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800902913600
更新日期:2009-01-01 00:00:00
abstract::Sutherlandia frutescens (Cancer bush), a Southern African indigenous plant, is traditionally used to treat stress related maladies linked to the endocrine system. Extracts of the shrub were used to investigate the claimed stress-relieving properties of the shrub. Dysregulation of the stress response is associated with...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-200044020
更新日期:2004-11-01 00:00:00
abstract::Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808609035438
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship b...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2015.1015730
更新日期:2015-01-01 00:00:00
abstract::X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120016999
更新日期:2002-11-01 00:00:00
abstract::Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809309035409
更新日期:1993-03-01 00:00:00
abstract::We report a novel mutant of the luteinizing hormone receptor (LHR) in a case of familial Leydig cell hypoplasia and pseudohermaphrotidism. The proband was homozygous for two missense mutations, T1121C and C1175T, causing substitutions I374T and T3921. The molecular effects of the mutations were investigated by heterol...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800500430890
更新日期:2005-01-01 00:00:00
abstract::Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435800.2018.1470639
更新日期:2018-11-01 00:00:00
abstract::Recent studies from our laboratory have shown that human chorionic gonadotropin (hCG), human luteinizing hormone (hLH), and CG-like proteins from Xanthomonas maltophilia (xCG) and Candida albicans (CaCGLP) induce Candida albicans transition from blastospores to hyphal forms. Xanthomonas maltophilia CG-like protein (xC...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809409035852
更新日期:1994-02-01 00:00:00
abstract:UNLABELLED:It remains difficult to pre-operatively differentiate follicular carcinoma and adenoma even under intraoperative investigations including histopathologic diagnosis of frozen sections. METHODS:We retrospectively compared dual phase thallium (Tl-201) thyroid scan and fine-needle aspiration (FNA) cytology to d...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120025036
更新日期:2003-08-01 00:00:00
abstract::Pretreatment of confluent human fibroblast cultures for two days in dexamethasone, serum free medium increased 10-20 fold the sensitivity of the cells to insulin-like growth factor I (IGF I) stimulation of amino acid uptake using the amino acid analog alpha-aminoisobutyric acid (AIB). This increased sensitivity result...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808909042743
更新日期:1989-01-01 00:00:00
abstract::In a previous study we demonstrated a significant increase of CD5+ B subset in patients with Graves' disease (GD) compared with normal controls. The aim of this study was to compare the percentage of CD5+ B and CD5- B cells in GD with that in different forms of autoimmune and non immune-mediated thyroid diseases. Seve...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809709031844
更新日期:1997-02-01 00:00:00
abstract::The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032700
更新日期:1998-08-01 00:00:00
abstract::Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP relea...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809009033011
更新日期:1990-01-01 00:00:00
abstract::Addition of cAMP (as the dibutyryl compound) to a primary culture of mouse Leydig cells caused the accumulation of a protein, i(b), with the same dependence on cAMP concentration as the increase in testosterone synthesis. Stimulation of both protein i(b) and testosterone production were inhibited by cycloheximide. Add...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808609035449
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effect of pioglitazone on serum uric acid (UA) levels and several diabetic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:The patients (n = 68) received 7.5-30 mg/day pioglitazone monotherapy. They were divided into t...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2012.745128
更新日期:2013-08-01 00:00:00
abstract::Pertussis toxin (PT) and cholera toxin (CT) have been shown to modulate lactogenic hormone-stimulated Nb2 cell mitogenesis, a lactogen-dependent cell line. As both toxins have been shown to alter guanylate cyclase activity in other cell systems, cyclic guanosine monophosphate (cGMP) analogs, 8-bromo or dibutyryl cGMP,...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809209035926
更新日期:1992-01-01 00:00:00
abstract:AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2016.1155597
更新日期:2017-02-01 00:00:00
abstract::The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809409030404
更新日期:1994-05-01 00:00:00
abstract::Recent evidence supports the hypothesis that sympathetic neurons play a significant role in the regulation of adrenocortical cell proliferation and steroidogenesis. Co-cultures of rat adrenocortical and sympathetic ganglion cells have been established to study sympatho-adrenal interactions. In these studies we have co...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435809609043786
更新日期:1996-11-01 00:00:00
abstract::Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A a...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1080/07435808409036505
更新日期:1984-01-01 00:00:00
abstract::Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435808709035466
更新日期:1987-01-01 00:00:00
abstract::There are two main regulatory sites of aldosterone biosynthesis, the early rate-limiting step by the P450scc and the final steps by the P450aldo. We have already demonstrated that, during gestation, activity and mRNA levels of P450aldo are increased. It has been shown that changes in sodium and potassium in the diet m...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435809809032648
更新日期:1998-08-01 00:00:00
abstract::The rat adrenal cortex possesses at least two mechanisms for uptake of extracellular lipoprotein cholesterol; one is receptor mediated endocytosis and the second is a non-endocytotic pathway. The latter was revealed by the ability of lipoproteins such as HDL which do not possess apo B or apo E to enhance steroid hormo...
journal_title:Endocrine research
pub_type: 杂志文章,评审
doi:10.1080/07435808409036509
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the expression of the glucose transporters GLUT1 and GLUT3 in papillary thyroid carcinomas (PTCs) and to elucidate their relationship with the BRAF V600E mutation and F-18 FDG uptake. MATERIALS AND METHODS:We retrospectively analyzed data of 52 PTC patients (41 women a...
journal_title:Endocrine research
pub_type: 杂志文章
doi:10.3109/07435800.2015.1066803
更新日期:2016-01-01 00:00:00