Abstract：
:There are several published reports on the prevalence of low vitamin D levels in otherwise healthy Indian population. Vitamin D deficiency has shown variable effect on muscle performance and strength but there is paucity of data on the effect of vitamin D deficiency on muscle energy metabolism. The present study was proposed to investigate the influence of severe vitamin D deficiency on high-energy metabolite levels in resting skeletal muscle and thereafter, monitor the response after vitamin D supplementation using ³¹P magnetic resonance spectroscopy (MRS). Study was conducted on 19 otherwise healthy subjects but with low serum 25(OH)D levels (<5 ng/ml). Subjects were supplemented with cholecalciferol at a dose of 60,000 IU/week for 12 weeks. MRS measurements of inorganic phosphate (Pi), phosphocreatine (PCr), phosphodiester (PDE) and ATP of the calf muscle were taken pre- and post-vitamin D supplementation. The study revealed significantly increased PCr/Pi ratio and decreased [Pi] and PDE/ATP ratio with raised serum 25(OH)D levels after 12 weeks of supplementation. The study indicates that serum 25(OH)D level plays an important role in improving the skeletal muscle energy metabolism and vitamin D deficiency might be one of the primary reasons for prevalence of low PCr/Pi ratio and high PDE values in normal Indian population as reported earlier. The findings of this preliminary study are highly encouraging and warrant further in-depth research, involving larger number of subjects of different age groups, regions and socio-economic sections of the society to further strengthen a correlation between vitamin D levels and muscle energy metabolism.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Rana P,Marwaha RK,Kumar P,Narang A,Devi MM,Tripathi RP,Khushu Sdoi
10.3109/07435800.2013.865210subject
Has Abstractpub_date
2014-01-01 00:00:00pages
152-6issue
4eissn
0743-5800issn
1532-4206journal_volume
39pub_type
临床试验,杂志文章abstract：:The adrenal cortex is a complex tissue comprising different cell types, including endocrine, stromal, nerve, perivascular, and endothelial cells. The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass. This suggests that paracrine secretions between steroidogen...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-200043623
更新日期：2004-11-01 00:00:00
abstract：:T3 receptors are ligand-dependent transcriptional activators that can stimulate gene expression resulting in growth and development. In this study T3 binding sites on isolated liver nuclei are demonstrated in the teleost Anabas testudineus. The effect of hypothyroidism and feeding of polyunsaturated fatty acids (PUFA)...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-100106010
更新日期：2001-08-01 00:00:00
abstract：INTRODUCTION:Charcoal- or resin-stripping of fetal bovine serum (FBS) or bovine calf serum (BCS) intended for supplementation of cell culture media is widely practiced to remove a variety of endogenous compounds, including steroid, peptide, and thyroid hormones. The possibility that stripping removes other biologically...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800903204082
更新日期：2009-01-01 00:00:00
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journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809809032628
更新日期：1998-08-01 00:00:00
abstract：:Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809309035409
更新日期：1993-03-01 00:00:00
abstract：:Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+ T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role fo...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800.2018.1470639
更新日期：2018-11-01 00:00:00
abstract：:Cerebrovascular accidents are one of the life-threatening complications of diabetic ketoacidosis (DKA) in children and adolescents. Our objective was to evaluate the effect of DKA and its treatment on factors known to affect thrombotic activity (protein C; protein S; von Willebrand factor, fibrinogen; homocysteine; an...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120018678
更新日期：2003-02-01 00:00:00
abstract：AIM:To determine whether hyperuricemia is associated with the early phase and late phase of insulin release in apparently healthy non-obese subjects with normal glucose tolerance. MATERIALS AND METHODS:A population-based cross-sectional study was performed. Apparently healthy individuals aged 20 to 65 years were eligi...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2016.1155597
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between th...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800.2011.640374
更新日期：2012-01-01 00:00:00
abstract：:Plasminogen activator inhibitor-1 (PAI-1) levels were found to be associated with obesity, indicating that adipocytes might influence PAI-1 plasma levels. In addition, the 4G/5G promoter polymorphism of the PAI-1 gene possibly modulates PAI-1 gene transcription and, as a consequence, PAI-1 plasma levels. Metabolic par...
journal_title：Endocrine research
pub_type： 临床试验,杂志文章
doi：10.1081/erc-200035728
更新日期：2004-08-01 00:00:00
abstract：:Standard replacement for adrenal insufficiency (AI) consists of glucocorticoids and mineralocorticoids while DHEA deficiency is routinely ignored. Thus, AI represents the ideal pathophysiological model of isolated DHEA deficiency. We investigated the effects of DHEA replacement in 24 women with primary and secondary A...
journal_title：Endocrine research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/07435800009048561
更新日期：2000-11-01 00:00:00
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journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435800500229151
更新日期：2005-01-01 00:00:00
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journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.1081/erc-120026947
更新日期：2003-11-01 00:00:00
abstract：:The effects of forskolin on the regulation of steroidogenesis and growth were examined in the Y1 adrenocortical tumor cell line, and the roles of cAMP and cAMP-dependent protein kinase in these actions of forskolin were evaluated. Forskolin, like corticotropin, stimulated steroidogenesis 3-fold and inhibited growth by...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435808509032978
更新日期：1985-01-01 00:00:00
abstract：:Recent studies from our laboratory have shown that human chorionic gonadotropin (hCG), human luteinizing hormone (hLH), and CG-like proteins from Xanthomonas maltophilia (xCG) and Candida albicans (CaCGLP) induce Candida albicans transition from blastospores to hyphal forms. Xanthomonas maltophilia CG-like protein (xC...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809409035852
更新日期：1994-02-01 00:00:00
abstract：:The CYP11B2 gene encodes aldosterone synthase, a cytochrome P450 (P450aldo) expressed in high levels in the adrenal zona glomerulosa. While the primary physiologic regulators of aldosterone production are circulating angiotensin II (Ang II) and potassium (K+) the action of these agents on CYP11B2 gene transcription ha...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809609043735
更新日期：1996-11-01 00:00:00
abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120015059
更新日期：2002-08-01 00:00:00
abstract：:In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thu...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809809032690
更新日期：1998-08-01 00:00:00
abstract：:The cdc2 kinase family is known to be one of the important factors for cell proliferation in both yeast and mammalian cells. By using polyclonal antibodies against PSTAIRE region of cdc2HS, we studied the amount of cdc2-related kinases in the rat thyroid cell line, FRTL-5, during the cell cycle. The immunoreactive pro...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809409030404
更新日期：1994-05-01 00:00:00
abstract：:Comparison of binding of 125I-porcine FSH to porcine granulosa cells from small and large ovarian follicles indicated that binding is dependent on both time and temperature. At 37 C, binding of ligand is more than four times higher in cells from small follicles than in cells from large follicles within 30 minutes of t...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809409035857
更新日期：1994-02-01 00:00:00
abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.3109/07435808909036356
更新日期：1989-01-01 00:00:00
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journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809909066140
更新日期：1999-05-01 00:00:00
abstract：:Total collagen and its soluble fraction as well as water content were determined in late pregnancy in the uterine cervix in a population of 36 rats treated with progesterone (n = 10), mifepristone (n = 13) and controls (n = 13). In both treated groups there were no signs of delivery on the 21st day of gestation. Water...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809509030477
更新日期：1995-08-01 00:00:00
abstract：:Recent evidence supports the hypothesis that sympathetic neurons play a significant role in the regulation of adrenocortical cell proliferation and steroidogenesis. Co-cultures of rat adrenocortical and sympathetic ganglion cells have been established to study sympatho-adrenal interactions. In these studies we have co...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1080/07435809609043786
更新日期：1996-11-01 00:00:00
abstract：:Y1 adrenocortical tumor cells possess amplified and overexpressed c-Ki-ras proto-oncogene, displaying chronic high levels of the c-Ki-Ras-GTP protein. Despite this oncogenic lesion, we previously reported that Y1 cells retain tight regulatory mechanisms of cell cycle control typified by the mitogenic response triggere...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-200043600
更新日期：2004-11-01 00:00:00
abstract：:The mechanisms by which SF-1 (Steroidogenic Factor-1) and Dax-1 (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome) dictate adrenal-specific transcriptional programs are the focus of this laboratory. SF-1-mediated transcription is upregulated by phosphorylation of serine 20...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435800009048628
更新日期：2000-11-01 00:00:00
abstract：:In order to investigate the regulation of connexin distribution in rapidly growing cells, we evaluated the effects of dibutyryl cyclic adenosine monophosphate (DbcAMP) treatment on the cellular location of endogenous connexin 43 (Cx43) in an adrenal tumor cell population. Polyclonal antibodies to Cx43 and a Cx43 green...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-120016983
更新日期：2002-11-01 00:00:00
abstract：:We established cell lines from adrenal tumors of transgenic mice harboring the large T-antigen of simian virus 40 under the control of the adrenocortical specific promoter of the scavenger aldose reductase-like akr1b7 gene. Mass spectrometry analyses of serum-supplemented or serum-free culture media showed that ATC1 l...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.1081/erc-200044168
更新日期：2004-11-01 00:00:00
abstract：:Two distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) with respect to enzymatic activity were identified in the ovine liver and kidney. 11 beta-HSD1 (the hepatic isoform) was reversible and NADP(H)-dependent. By contrast, 11 beta-HSD2 (the renal isoform) was unidirectional and NAD-dependent. Ovin...
journal_title：Endocrine research
pub_type： 杂志文章,评审
doi：10.3109/07435809509030453
更新日期：1995-02-01 00:00:00
abstract：:The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein...
journal_title：Endocrine research
pub_type： 杂志文章
doi：10.3109/07435809809032720
更新日期：1998-08-01 00:00:00
